ISSN:
1432-1246
Keywords:
Lead exposure
;
ALA.D
;
Immunological assay on a centrifugal fast analyser
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The δ-aminolevulinate dehydratase (ALA.D) quantitative assay on a centrifugal fast analyser showed that subjects whose blood-lead level varies between 30 and 75 μtg/100 ml (1.5 to 3.75 μM/l) react to blood intoxication by synthesizing de novo an amount of enzyme correlating to blood-lead levels. At higher concentrations, the reactional synthesis occurs very rarely. These results suggest that enzyme is constitutive, but also inductible as soon as its substrate accumulates; this last ability may disappear at high blood-lead levels: a hypothesis is proposed thereafter.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00378071
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