ISSN:
1420-9071
Keywords:
Large granular lymphocytes
;
retrovirus
;
infection
;
cell proliferation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The effect of infection with a retrovirus carryingv-raf/v-myc oncogenes (J2 virus) on the in vitro proliferation of human large granular lymphocytes (LGL) was investigated. LGL infected with J2 virus (J2LGL), unlike uninfected cells, grew with a proliferation peak eight days after infection. Such cells retained the morphology and functional properties typical of LGL. Furthermore, 5% of J2LGL produced virus the day after infection, whereas non-virus production was detectable five days later. These data indicate that J2 virus provides a transient mitogenic signal for LGL.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01939906