Description: The asymmetric policy and science domains, face a number of challenges when it comes to managing disaster risk. On the one hand, policy stakeholders require reliable, high-quality information in order to make well-informed decisions in a timely manner, while on the other, creation of sound scientific information upon which such decisions can and should be made, requires time and thoroughness. As a result, uncertainty plays a crucial role when it comes to integrating scientific information into the decision-making process. To explore further the ways in which uncertainty affects decision-making, the ESPREssO Project developed a serious game for disaster risk reduction (DRR) stakeholders to “play,” termed RAMSETE III. It aims to assess how uncertainty impacts processing of early warning information and subsequent decision-making (such as ordering evacuations), embedded within a fictitious geographic, policy and practice setting. Serious gaming can serve as an useful tool to allow stakeholders with very different backgrounds to work closer together in a simulated environment. Different operational timescales and misunderstandings arising from differing perceptions of risk and uncertainty between policy stakeholders and scientists, are identified as key barriers hindering effective integration of policy and science in disaster management. Hence, RAMSETE III was employed to initiate open discourse between DRR stakeholders across the science-policy spectrum. The main outcome of this game emphasizes that to overcome these identified barriers, a collaborative, interdisciplinary, and inclusive approach is needed as a first-step foundation, with enhanced efforts in communication and development of common terminologies to assist strengthening of mutual understanding.