Note: Intro -- Stem Cells and COVID-19 -- Copyright -- Contents -- Contributors -- Preface -- Chapter 1 Introduction -- References -- Chapter 2 Characteristics and immunobiology of COVID-19 -- Introduction -- Structure and etiology -- Pathology of infection -- Immunology and signaling mechanisms -- Cytokine storm -- Current treatment approaches -- Translational avenues and perspectives -- Acknowledgments -- Conflict of Interests -- References -- Chapter 3 An insight into the molecular mechanisms of mesenchymal stem cells and their translational approaches to combat ... -- Introduction and background -- Pathophysiology of SARS-CoV-2 -- Conventional and contemporary translational approaches to combat COVID-19 -- Drugs -- Convalescent plasma therapy -- Vaccines -- Stem cell therapy as a novel translation approach against the COVID-19 pandemic -- Molecular mechanisms exhibited by mesenchymal stem cells to combat SARS-CoV-2 infection -- Regeneration by differentiation -- Immunomodulatory and antiinflammatory effect of MSCs -- Mitochondrial transfer as a rescue mechanism -- The paracrine effect -- Conclusion and outlook for the future -- Acknowledgment -- Conflict of interest -- Financial support -- References -- Chapter 4 Inflammatory multisystem syndrome in COVID-19: Insights on off-target organ system in susceptible and recovering ... -- Introduction -- Antigen processing and immune responses in COVID-19 -- Cytokine storm -- Inflammation in COVID-19 -- Respiratory system failure -- Cardiovascular manifestations in COVID-19 -- Neurological and renal manifestation of COVID-19 -- GI tract manifestations -- Conclusion -- Acknowledgment -- References -- Chapter 5 Cytokine storm and stem cell activation in unveiling potential targets for diagnosis and therapy -- Introduction -- Cytokine storms -- Cytokine storms in viral respiratory infections. , Influenza shapes the idea of a cytokine storm -- Lessons from SARS -- The COVID-19 cytokine storm -- Cytokine storms and stem cells -- Impact of cytokines on stem cell activation -- Using mesenchymal stem cells as COVID-19 therapies -- Conclusion -- Acknowledgments -- References -- Chapter 6 Mesenchymal stem cells: Novel avenues in combating COVID-19 -- Introduction -- Alveolar cell and SARS-COVID-19 -- Cytokine storm -- Mechanism of cytokine storm -- The reason behind using mesenchymal stem cells -- Bioprinting and COVID-19 -- Prebioprinting -- Bioprinting -- Postbioprinting -- Stereolithography -- Inkjet bioprinting -- Laser-assisted printing -- Extrusion printing -- In vitro organ models and organ chips for lungs modeling -- Paracrine and immunomodulatory effects of MSCs -- Conclusion -- References -- Chapter 7 Immunomodulatory properties of mesenchymal stem cells and hematopoietic stem cells-Potential therapeutic target ... -- Introduction -- COVID-19 and the cytokine storm -- MSC as a cellular therapy -- Specific immunomodulatory changes -- Lung damage and restoration by MSC administration -- Hematopoietic stem cells -- Translational potential of MSCs -- Conclusion -- Acknowledgments -- References -- Chapter 8 COVID-19 and acute myocardial injury: Stem cell driven tissue remodeling in COVID-19 infection -- Introduction -- COVID-19: Etiology, transmission, structure, and pathophysiology -- COVID-19-CVD comorbidity -- Stem cells in cardiac remodeling -- ACE2 signaling and cardiac pathology COVID-19 infection -- Stem cell activation and signaling in ACE2 upregulation -- Cytokine surge and stem cell activation in MI -- Sheddases' response in cardiac stem cell differentiation (major focus to TMPRSS2, CTSL, and ADAM17) -- Perspectives in COVID-19 and cardiac responses -- Translational avenues and future -- References. , Chapter 9 Stem cell-driven tissue regeneration as treatment for COVID-19 -- Introduction -- Management of COVID-19 by stem cells -- Tissue-resident stem cells -- Hematopoietic stem cells -- Embryonic stem cells -- Mesenchymal stem cells -- Stem cell activation during pathology -- Growth factors as a vital target -- COVID-19 clinical trials -- Potential drawbacks of the trials -- To consider [65] -- Summary and significance -- References -- Chapter 10 Stem cell transplantation for COVID-19 management: Translational possibilities and future -- Introduction -- Sources of stem cells -- Use of different types of stem cells in translational research -- Current COVID-19 related clinical trials using stem cells -- Challenges of using stem cells and future perspective -- Conclusion -- References -- Chapter 11 Therapeutic scale stem cell-derived exosomes for COVID-19: Models-Validation, management, and strategies -- Introduction to Covid-19 -- Pathophysiology -- Interventions -- Stem cell population/product condition addressed outcome -- Exosome for management -- Exosome challenges -- References -- Chapter 12 Current strategies and future perspectives in COVID-19 therapy -- Introduction -- COVID-19: An overview -- SARS-CoV-2 virus etiology -- SARS-CoV-2 structure -- Manifestation and transmission of COVID-19 -- Modes of transmission -- Contact and droplet transmission -- Airborne transmission -- Fomite transmission -- Other modes of transmission -- Prevention of transmission -- COVID-19 diagnosis -- Current treatment strategies -- Drug repurposing for pathogen targeting -- Immunomodulation in COVID-19 -- Immune response against SARS-CoV-2 -- Potential immunotherapy in COVID-19 -- Biological immunomodulating drugs -- Targeted synthetic immunosuppressants -- Role of anticoagulant, antiplatelet therapy, and statins in COVID-19. , Anticoagulant therapy for patients admitted with COVID-19 -- Antiplatelet therapy for patients admitted with COVID-19 -- Correlation between statins and COVID-19 -- Convalescent plasma therapy -- Cell-based therapy -- Vaccines -- Future perspectives -- Impact of formulations and route of administration -- Biomaterial and tissue engineering strategies -- Biomaterial-based drug delivery systems -- Biomaterial-based vaccine platforms -- 3D in vitro tissue models -- Conclusion -- Acknowledgments -- References -- Index.