Publication Date:
2015-11-23
Description:
Publication date: Available online 17 November 2015 Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Kaja Breckwoldt, Florian Weinberger, Thomas Eschenhagen Regenerating an injured heart holds great promise for millions of patients suffering from heart diseases. Since the human heart has very limited regenerative capacity, this is a challenging task. Numerous strategies aiming to improve heart function have been developed. In this review we focus on approaches intending to replace damaged heart muscle by new cardiomyocytes. Different strategies for the production of cardiomyocytes from human embryonic stem cells or human induced pluripotent stem cells, by direct reprogramming and induction of cardiomyocyte proliferation are discussed regarding their therapeutic potential and respective advantages and disadvantages. Furthermore, different methods for the transplantation of pluripotent stem cell-derived cardiomyocytes are described and their clinical perspectives are discussed.
Print ISSN:
0167-4889
Electronic ISSN:
1879-2596
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Physics
