Description: Expression levels of genes vary not only between different environmental conditions ("plasticity") but also between genetically identical cells in constant environment ("noise"). Intriguingly, these two measures of gene expression variability correlate positively with each other in yeast. This coupling was found to be particularly strong for genes with specific promoter architecture (TATA box and high nucleosome occupancy) but weak for genes in which high noise may be detrimental ( e.g. , essential genes), suggesting that noise–plasticity coupling is an evolvable trait in yeast and may constrain evolution of gene expression and promoter usage. Recently, similar genome-wide data on noise and plasticity have become available for Escherichia coli , providing the opportunity to study noise–plasticity correlation and its mechanism in a prokaryote, which follows a fundamentally different mode of transcription regulation than a eukaryote such as yeast. Using these data, I found significant positive correlation between noise and plasticity in E. coli . Furthermore, this coupling was highly influenced by the following: level of expression; essentiality and dosage sensitivity of genes; regulation by specific nucleoid-associated proteins, transcription factors, and sigma factors; and involvement in stress response. Many of these features are analogous to those found to influence noise–plasticity coupling in yeast. These results not only show the generality of noise–plasticity coupling across phylogenetically distant organisms but also suggest that its mechanism may be similar.