Publication Date:
2014-08-25
Description:
After 96 h goldfish exposure to 10, 25 or 50 mg/L of Ni2 + no Ni accumulation was found in the brain, but lipid peroxide concentration was by 44% elevated in the brain, whereas carbonyl protein content was by 45–45% decreased in the heart. High molecular mass thiol concentration was enhanced by 30% in the heart, while in the brain low molecular mass thiol concentration increased by 28–88%. Superoxide dismutase activity was by 27% and 35% increased in the brain and heart, respectively. Glutathione peroxidase activity was lowered to 38% and 62% of control values in both tissues, whereas catalase activity was increased in the heart by 15–45%, accompanied by 18–29% decreased glutathione reductase activity. The disturbances of free radical processes in the brain and heart might result from Ni-induced injuries to other organs with more prominent changes in the heart, because of close contact of this organ with blood, whereas the blood–brain barrier seems to protect the brain.
Repository Name:
EPIC Alfred Wegener Institut
Type:
Article
,
isiRev
