In:
Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 68, No. 02 ( 1992), p. 130-135
Abstract:
The native fibrin gel structure formed in vitro from plasma samples was examined by liquid permeation of the hydrated fibrin gel networks in 18 men who had suffered a myocardial infarction before the age of 45 years and in 20 control subjects. Patients with an elevated plasma fibrinogen concentration had a considerably lower fibrin gel porosity (permeability coefficient, K
s) compared with patients with a normal plasma fibrinogen level and with controls. The calculated fiber mass-length ratio of the fibrin gel networks was decreased in both patient groups. Gel porosity differed markedly between individuals at a given plasma fibrinogen concentration. Fairly strong inverse correlations were found between plasma orosomucoid level on the one hand and K s (r = –0.617, p 〈 0.01) or fiber mass-length ratio (r = –0.499, p 〈 0.05) on the other. The low density lipoprotein (LDL) cholesterol concentration also correlated inversely with K
s (r = –0.471, p 〈 0.05) and fiber mass-length ratio (r = –.522, p 〈 0.05). Significant inverse relations, which were independent of plasma fibrinogen and lipoprotein concentrations, were detected between K
s (r = –.519, p 〈 0.05) and calculated fiber mass-length ratio (r = –.723, p 〈 0.001) and number and severity of coronary artery stenoses determined by angiography. A proneness to formation of tight, rigid and space-filling fibrin network structures with small pores thus appears to be associated with premature coronary artery disease.
Type of Medium:
Online Resource
ISSN:
0340-6245
,
2567-689X
DOI:
10.1055/s-0038-1656337
Language:
English
Publisher:
Georg Thieme Verlag KG
Publication Date:
1992
