Publication Date:
2014-12-04
Description:
Article Hereditary hypertrophic cardiomyopathy (HCM) is caused by mutations in cardiomyocyte genes, such as MYBPC3 . Here, the authors use virus-mediated gene therapy to correct Mycbpc3 mutations in 1-day-old mice and, by administering just a single dose, prevent development of HCM over a period of 34 weeks. Nature Communications doi: 10.1038/ncomms6515 Authors: Giulia Mearini, Doreen Stimpel, Birgit Geertz, Florian Weinberger, Elisabeth Krämer, Saskia Schlossarek, Julia Mourot-Filiatre, Andrea Stoehr, Alexander Dutsch, Paul J. M. Wijnker, Ingke Braren, Hugo A. Katus, Oliver J. Müller, Thomas Voit, Thomas Eschenhagen, Lucie Carrier
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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