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  • Immunocytochemistry  (1,291)
  • Springer  (1,291)
  • Blackwell Science Ltd
Document type
Keywords
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  • 1
    Electronic Resource
    Electronic Resource
    Detection of free malignant cells in the peritoneal cavity before and after resection of colorectal cancer (1994)
    Springer
    Diseases of the colon & rectum 37 (1994), S. 814-819 
    Details
    ISSN: 1530-0358
    Keywords: Colorectal cancer ; Metastasis ; Free peritoneal malignant cells ; Conventional cytology ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PURPOSE: This study was designed to select the best monoclonal antibody to stain malignant cells in peritoneal wash fluid, and to investigate the incidence of free malignant cells in preresection and postresection colorectal cancer peritoneal washings using a combination of conventional cytology and immunocytochemistry. METHODS: Peritoneal washings were taken from 35 consecutive patients undergoing colorectal cancer resection. RESULTS: Malignant cells were isolated on a density gradient and identified by conventional cytology and an indirect immunoperoxidase stain. Malignant cells were identified in peritoneal washings from 15 patients (preresection only n=3, postresection only n=4, both n= 8). The origin of free malignant peritoneal cells in 11 preresection-positive washings must be the serosa. The origin of these cells in the four postresection-positive patients is uncertain: serosal and luminal spillage were considered unlikely and no circulating cells were found in the mesenteric vessels near the tumor. CONCLUSION: Tumor cells may have leaked out from lymphatics cut during the dissection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02050147
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  • 2
    Electronic Resource
    Electronic Resource
    Immunocytochemical assay for androgen receptors in prostate cancer: A prospective study of 63 cases with long-term follow-up (1994)
    Springer
    Annals of surgical oncology 1 (1994), S. 495-503 
    Details
    ISSN: 1534-4681
    Keywords: Prostate cancer ; Androgen receptors ; Immunocytochemistry ; Prognostic data
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: Numerous problems are associated with biochemical androgen receptor (AR) assay performance and interpretation in prostatic cancer. The purpose of this study was to determine if a novel immunocytochemical AR assay performed on intact tissue sections would prove useful in prognosticating endocrine response and survival. Methods: A prospective study was done on 63 prostatic carcinomas maintained in liquid nitrogen for over a decade. The study used the peroxidaseantiperoxidase system and a polyclonal anti-AR antibody. Results: Marked tissue and cellular heterogeneity of nuclear AR was apparent. A cut-off of 10% AR-positive cells maximized assay prognostic efficiency. Frequency of positivity was 48% and correlated significantly with endocrine response (p=0.03), time to progression (p=0.0016), and survival (p=0.02), but not with grade, stage, or ethnicity. Conclusions: This AR assay could be prognostically useful in the clinical management of prostate cancer and is suitable for use in the community hospital laboratory.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02303615
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  • 3
    Electronic Resource
    Electronic Resource
    Occurrence and distribution of GRP-immunoreactive nerve fibres in the respiratory tract (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 145-151 
    Details
    ISSN: 1434-4726
    Keywords: Gastrin releasing peptide ; Respiratory tract ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The occurrence and distribution of nerve fibres containing gastrin-releasing peptide (GRP) were investigated in the respiratory tract of several mammals using immunocytochemistry. A moderate supply of nerve fibres displaying GRP immunoreactivity was seen in the middle ear mucosa, the nasal mucosa and the tracheobronchial wall. Generally, the fibres were distributed around blood vessels and seromucous glands. In addition, scattered GRP fibres were seen in the smooth muscle of the tracheal wall. The distribution of GRP fibres in the respiratory tract suggests multiple functions of GRP such as regulation of local blood flow, glandular secretion and smooth muscle activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00463555
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  • 4
    Electronic Resource
    Electronic Resource
    Substance-P-containing nerve fibers in the nasal mucosa (1983)
    Springer
    European archives of oto-rhino-laryngology and head & neck 238 (1983), S. 9-16 
    Details
    ISSN: 1434-4726
    Keywords: Nasal mucosa ; Substance P ; Neuropeptides ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nerve fibers displaying SP immunoreactivity were detected in the nasal mucosa of several mammals. The fibers were seen around small blood vessels, seromucous glands, and beneath and sometimes within the surface epithelium. In the pterygopalatine ganglion and the trigeminal ganglion, known to innervate the nasal mucosa, SP-positive nerve cell bodies were seen. Sympathetic denervation with 6-hydroxydopamine (6-OHDA) or bilateral cervical sympathectomy did not visibly affect the distribution of SP fibers in the nasal mucosa in mice or rats. The findings are compatible with the view that the bulk of SP fibers to the nasal mucosa derive from the trigeminal ganglion with a possible contribution from the pterygopalatine ganglion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00453736
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  • 5
    Electronic Resource
    Electronic Resource
    Specific alterations of the basement membrane and stroma antigens in Human pituitary tumours in comparison with the normal anterior pituitary. An immunocytochemical study (1992)
    Springer
    Virchows Archiv 421 (1992), S. 449-455 
    Details
    ISSN: 1432-2307
    Keywords: Pituitary adenoma ; Human anterior pituitary ; Basement membrane ; Immunocytochemistry ; Neovascularization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Our report is the first immunocytochemical study of the principal elements of the basement membrane (BM) and connective tissue in normal and adenomatous human anterior pituitaries. In normal tissues, both the parenchymatous BM limiting the endocrine cell cords and the endothelial BM around the capillaries were continuous and were stained with anti-laminin (LM), anti-type IV collagen (CIV) and anti-fibronectin (FN) antisera. Antiserum to type I collagen (CI) stained the connective tissue only. The same antigens were investigated in 23 human pituitary adenomas, 6 of them having been diagnosed as locally invasive by the radiologist and the neurosurgeon. In all cases a lack of cordai structure was observed and the parenchymatous BM was completely absent (9 cases) or fragmented (14 cases). No correlation could be established between the extent of parenchymatous BM alterations and the invasive behaviour of the tumour. In contrast, a continuous endothelial BM was observed around the blood vessels in all cases and its presence was confirmed in double immunofluorescence experiments using anti-von Willebrand factor and anti-LM or anti-CIV antisera. Anti-FN and CI also stained the wall of the vessels. The tumours showed arterial development, in addition to the capillaries found in normal tissue. The present results favour the hypothesis of a decreased synthesis of parenchymatous BM by human adenomatous pituitary cells in comparison with normal cells and show that these tumours are the site of an active arterial neovascularization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01606873
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  • 6
    Electronic Resource
    Electronic Resource
    Adrenergic and peptidergic innervation of cochlear blood vessels (1982)
    Springer
    European archives of oto-rhino-laryngology and head & neck 236 (1982), S. 7-14 
    Details
    ISSN: 1434-4726
    Keywords: Cochlear blood vessels ; Neuropeptides ; Immunocytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Guinea pig cochlear blood vessels were investigated with regard to their supply of adrenergic and peptidergic nerve fibers. Using the glyoxylic acid histofluorescence technique, numerous adrenergic fibers were seen around the labyrinthine artery, whereas the spiral modiolar artery contained only few such fibers. Immunocytochemistry revealed nerve fibers containing immunoreactive avian pancreatic polypeptide, vasoactive intestinal peptide, substance P, or gastrin-releasing peptide around the labyrinthine and spiral modiolar arteries. Adrenergic or peptidergic nerve fibers were not seen around the blood vessels of the stria vascularis. Upon removal of the superior cervical ganglion, adrenergic fibers disappeared and fibers displaying avian pancreatic polypeptide immunoreactivity were reduced in number. These data suggest co-occurrence of catecholamines and immunoreactive avian pancreatic polypeptide in a population of adrenergic nerves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00464052
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  • 7
    Electronic Resource
    Electronic Resource
    Occurrence, distribution and nature of neuropeptide Y in the rat pancreas (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1554-1557 
    Details
    ISSN: 1420-9071
    Keywords: Immunocytochemistry ; neuropeptide Y ; radioimmunoassay ; rat pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Significant quantities of a newly discovered peptide, neuropeptide Y, were found in the rat pancreas, where they were localized to nerves in the exocrine parenchyma and around arterial and ductal structures. Although unaffected by surgical parasympathectomy, the periarterial and periductal nerves were abolished by chemical sympathectomy, suggesting that NPY is partially costored with sympathetic transmitters in nerve fibers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964804
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  • 8
    Electronic Resource
    Electronic Resource
    Immunocytochemical evidence of phospholipase A2 in pancreatic tumors — Diagnostic values (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 136-140 
    Details
    ISSN: 1432-1440
    Keywords: Immunocytochemistry ; Phospholipase A2 ; Pancreatic tumors ; Acinar-cell carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phospholipase A2 is an enzyme which is produced in acinar cells, and persists even in regressive states of chronic pancreatitis, when the production of other enzymes diminishes. We therefore tested this enzyme as a marker of acinar descent in various pancreatic tumors. This enzyme could be seen in 50% of the acinar-cell carcinomas, in 60% of solid and papillary pancreatic tumors, and in 50% of microglandular carcinomas. Ductal cancers and isletcell cancers were negative. In contrast to other markers of acinar matrix (amylase, antitrypsin), phospholipase A2 gave fewer false-positive or false-negative results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01711339
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  • 9
    Electronic Resource
    Electronic Resource
    Class differentiation of immunoglobulin-containing cerebrospinal fluid cells in inflammatory diseases of the central nervous system (1990)
    Springer
    Journal of molecular medicine 68 (1990), S. 12-17 
    Details
    ISSN: 1432-1440
    Keywords: Immunoglobulin-containing cells ; Cerebrospinal fluid ; Immunocytochemistry ; Inflammatory diseases ; HIV-encephalitis ; Multiple sclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An immunocytochemical technique allowing repeated use of antisera is applied to identify immunoglobulin-containing cells (ICC) of the IgG, IgA, and IgM class in the cerebrospinal fluid (CSF) of 298 patients with various neurological disorders. The demonstration of ICC in the CSF is highly indicative of an inflammatory disease (p〈0.0001; Chi-square test). In the group of noninflammatory disorders ICC are only found in three cases of lymphomas, two dysgerminomas, and one glioblastoma. ICC of all classes are seen in acute viral and bacterial infections of the CNS including tick-borne meningopolyneuritis Bannwarth. IgG-positive ICC predominate in chronic inflammatory disorders like multiple sclerosis and HIV encephalitis. In HIV-positive patients IgA-or IgM-positive cells are strongly indicative of an opportunistic infection of the brain. Persistent high levels of ICC in three patients with bacterial meningitis are associated with a fatal outcome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01648883
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  • 10
    Electronic Resource
    Electronic Resource
    Immunocytochemical detection of p21 ras expression in fresh human leukaemic cells and cell lines (1989)
    Springer
    Annals of hematology 59 (1989), S. 460-463 
    Details
    ISSN: 1432-0584
    Keywords: Immunocytochemistry ; Leukaemia ; Oncogenes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The expression of p21 ras proteins was investigated by immunocytochemistry in permanent cell lines and in fresh human leukaemic cells. While high and low levels of p21 ras could be detected in most of the cell lines, no significant p21 ras immunoreactivity was noted in cells of ten human acute and chronic leukaemias. Thus, notwithstanding its possible role in the initial transformation process in human leukaemias, p21 ras expression appears not to be an irrevocable requirement for the maintenance of the transformed state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00349069
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