Keywords:
Cytokines.
;
Electronic books.
Type of Medium:
Online Resource
Pages:
1 online resource (329 pages)
Edition:
1st ed.
ISBN:
9780080582252
Series Statement:
Issn Series
URL:
https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=403594
DDC:
612/.01575
Language:
English
Note:
Front Cover -- Advances in Protein Chemistry, Volume 52 -- Copyright Page -- Contents -- Preface -- Chapter 1. General Classes and Functions of Four-Helix Bundle Cytokines -- I. Overview -- II. Long-Chain Cytokines Using Homodimeric Type I Cytokine Receptors for Signaling -- III. Short-Chain Cytokines Using Homodimeric Tyrosine Kinase Receptors for Signaling: Macrophage Colony-Stimulating Factor, Stem Cell Factor, and FLK2/FLT3 Ligand -- IV. Long-Chain Cytokines Using Leukemia Inhibitory Factor Receptors and/or gp130 for Signaling: Pleiotropic Cytokines: Interleukin-6, Interleukin-11, Leukemia Inhibitory Factor, Oncostatin M, Ciliary Neurotrophic Factor, and Cardiotrophin-1 -- V. Short-Chain Cytokines Using βc for Signaling: Hemopoietic Cytokines: Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-3, and Interleukin-5 -- VI. Cytokines Using Class II Cytokine Receptors for Signaling: Viral Resistance Cytokines: Interferons, Interleukin-10, and Interleukin-12 -- VII. Short-Chain Cytokines Using γc or Interleukin-4 Receptor for Signaling: Acquired Immunity Cytokines: Interleukins-2, -4, -7, -9, -13, and -15 -- VIII. Concluding Comments -- References -- Chapter 2. Structural Basis for Cytokine Hormone-Receptor Recognition and Receptor Activation -- I. Introduction -- II. Class 1 of the Superfamily -- III. Class 2 of the Superfamily -- IV. Comparison of Class 1 and Class 2 Receptors -- References -- Chapter 3. General Mechanisms of Cytokine Receptor Signaling -- I. Introduction -- II. Multicomponent Receptors for the Interleukin 6/Ciliary Neurotrophic Factor Cytokine Family: Shared Signal Transducing Receptor Components -- III. Cytokine Binding Drives Receptor Complex Assembly -- IV. Homo- or Heterodimerization of Signal Transducing Components is Required for Signaling: JAK Kinases are Preassociated with Signal Transducers.
,
V. Shared Principles of Receptor Activation by Different Cytokine Families and Receptor Tyrosine Kinases -- VI. STATs and Other Substrates Activated by Cytokine Receptors -- VII. Choice of STATs and Other Substrates Specified by Modular Tyrosine-Based Motifs in Cytokine Receptors -- VIII. Phosphatases and Other Regulators of Cytokine Receptor Signaling -- IX. Therapeutic Approaches for Modulating Cytokine Signaling -- References -- Chapter 4. Cytokines in Hematopoiesis: Specificity and Redundancy in Receptor Function -- I. Introduction -- II. Structure and Regulation of Hematopoietic Compartment -- III. Historical Perspective -- IV. Experimental Models to Study Cytokine Receptors -- V. Inductive versus Stochastic Models of Hematopoiesis -- VI. Cytokine Receptor Signaling -- VII. Pathological Effects of Aberrant Cytokine Receptor Function -- VIII. Summary and Future Perspectives -- References -- Chapter 5. Cytokines in Endocrine Function -- I. Introduction -- II. Growth Hormone Signal Transduction -- III. Growth Hormone Receptor Dimerization and Antagonists -- IV. Impact of Molecular Defects of the Receptor -- V. Tissue Dictating Growth Hormone Receptor Requirements -- VI. Pulsatile Growth Hormone -- VII. Clinical Relevance of Growth Hormone Receptor/ Therapeutic Implications -- VIII. Conclusion -- References -- Chapter 6. Cytokines in Brain Development and Function -- I. Introduction -- II. Role of Cytokines in Regulation of Neurogenesis -- III. Cytokine Subgroups: Specific Roles and Regulation of Expression in Nervous System -- IV. Cytokine Regulation of Neurogenesis: Patterns of Expression of Hemopoietins, Receptors, and Signaling Molecules -- V. Summary and Future Directions -- References -- Author Index -- Subject Index.
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