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  • Ultrastructure  (563)
  • Molecular Cell Biology  (515)
  • 1975-1979  (1,078)
  • 1
    Electronic Resource
    Electronic Resource
    Ultrastructural studies on the myocardial capillaries of the experimentally lathyritic rat, protective effect of certain flavonoids (1975)
    Springer
    Virchows Archiv 365 (1975), S. 201-212 
    Details
    ISSN: 1432-2307
    Keywords: Lathyrism ; Capillaries ; Rat ; Ultrastructure ; Flavonoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The ultrastructure of rat myocardial capillaries was studied in the course of experimental lathyrism. Endothelial cells were hypertrophic, with a sinuous profile of the plasma membrane facing the lumen and with a consistent increase of pinocytotic vesicles; the nuclei were irregular in shape; ATPase activity was no more demonstrable. Therefore, various and well distinct structural endothelial mechanisms seem to be primarily involved, causing an alteration of the dynamics of transcellular exchanges and of the permeability of the vascular wall. Simultaneous treatment with certain flavonoids, (O-(β-hydroxyethyl)-rutosides and Na(+)-epicatechin-2-sulfonate), resulted in a less pronounced alteration and a more rapid recovery. The possibility of the existence of a common site of action of lathyrogens and flavonoids is raised in the discussion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00434039
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  • 2
    Electronic Resource
    Electronic Resource
    Adrenal adenomata causing primary aldosteronism (1979)
    Springer
    Virchows Archiv 384 (1979), S. 93-102 
    Details
    ISSN: 1432-2307
    Keywords: Primary aldosteronism ; Adrenal adenomata ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Adenomata taken from 25 patients with primary aldosteronism were observed by electron microscopy. The cells in the adenoma had a well developed agranular endoplasmic reticulum but granular endoplasmic reticulum was not prominent. Most of the mitochondria resembled those in the cells of the zona glomerulosa, suggesting that the adenomata which caused primary aldosteronism are derived from this zone. Spironolactone bodies were found in the cells of the adenoma from a patient who received spironolactone. Their appearance was identical to that descrived in previous reports.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427154
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  • 3
    Electronic Resource
    Electronic Resource
    The autoimmune submandibular sialoadenitis of the NZB/NZW hybrid mice (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 225 (1979), S. 57-65 
    Details
    ISSN: 1434-4726
    Keywords: NZB/NZW-Maus ; Ultrastruktur ; Submandibulare Speicheldrüse ; Lymphocyten ; Autoimmunes Leiden ; NZB/NZW mouse ; Ultrastructure ; Submandibular gland ; Lymphocytes ; Autoimmune disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary An electron microscopic study of the submandibular salivary gland lesion occurring in the NZB/NZW F1 hybrid mice was performed, and the findings were discussed and correlated to the autoimmune salivary gland disease observed in patients with Sjögren's syndrome. Within the submandibular salivary gland of this mouse strain focal infiltrates of mononuclear inflammatory cells were observed. Lymphoid cells were observed inside the basal lamina of acini and ducts, leading to destruction of these glandular units. The typical duct cell proliferation found in the autoimmune sialoadenitis of Sjögren's syndrome with the formation of the typical epimyoepithelial islands was not found in the submandibular glands of NZB/NZW mice.
    Notes: Zusammenfassung Eine elektronenmikroskopische Untersuchung der bei den NZB/NZW F1 hybriden Mäusen vorkommenden Veränderungen in den submandibularen Speicheldrüsen wurde durchgeführt, und die Befunde wurden diskutiert und korreliert mit dem autoimmunen Speicheldrüsenleiden, das bei Patienten mit Sjögrens-Syndrom beobachtet wird. In der submandibularen Speicheldrüse dieses Mäusestammes wurden begrenzte Infiltrationen mononuklearer inflammatorischer Zellen beobachtet. Die mononuklearen Zellen wurden hauptsächlich als lymphoide Zellen identifiziert. Außerdem wurden innerhalb der Lamina basilaris von Drüsen und Drüsengängen lymphoide Zellen beobachtet, die zur Zerstörung dieser Drüseneinheiten führen. Darüber hinaus wurde der typische Zuwachs der Drüsengangszellen, der bei der autoimmunen Speicheldrüsenentzündung des Sjögrens-Syndroms vorkommt und die Form von typischen epimyoepithelialen Inseln annimmt, in den submandibularen Drüsen der NZB/NZW-Mäuse nicht vorgefunden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455876
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  • 4
    Electronic Resource
    Electronic Resource
    Functions of different receptor systems in the reptilian labyrinth (1979)
    Springer
    European archives of oto-rhino-laryngology and head & neck 224 (1979), S. 31-35 
    Details
    ISSN: 1434-4726
    Keywords: Intracellular potentials ; Ultrastructure ; Hair cells ; Labyrinth receptors ; Reptilia (Crocodilia, Gekkonidae)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Different biopotentials, following a mechanical stimulus, were recorded from single hair cells of the reptilian labyrinth, with electronoptically circumscript localizations: 1. From the apical cell pole, the receptor potential, intracellular or from the ciliary surface, within the physiological range proportional to stimulus amplitude, frequency or phase, without delay, and with no real threshold of mechanosensitivity, as measured by ciliary displacement amplitude or velocity. 2. From the synaptic zone, in the basal region of the hair cell, or from contacting nerve endings, the synaptic potentials, local excitatory or inhibitory processes, respectively, with measurable latencies and with non-linear distortion. 3. From the (dendritic) endings of the first afferent neuron (or neurons), spike-shaped action potentials, synchronized by the (excitatory) synaptic potentials. Characteristic curves were plotted as a quantitative representation of the mechano-electric input-output relations of the different types of hair cells. For proceeding morphological and physiological system analysis, the comparison of the different submammalian inner-ear receptor systems gives us some new possibilities of a closer correlation between ultrastructure and function.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00455221
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  • 5
    Electronic Resource
    Electronic Resource
    Morphologic alterations in the epithelium of the human oviduct induced by a low dosis gestagen (1977)
    Springer
    Archives of gynecology and obstetrics 223 (1977), S. 269-281 
    Details
    ISSN: 1432-0711
    Keywords: Oviduct ; Gestagen ; Contraception ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Morphological alterations in the epithelium of the human oviduct related to continuous administration of low dosage lynestrenol were studied in 10 women by electron microscopy. The effect of lynestrenol on the morphology of the tubal epithelium was shown to be time dependent. First the discharge of secretory products from the non-ciliated cells was inhibited. Secondary to this the synthetic activities of the cells were drastically decreased. This inactivation of the tubal epithelium reached its maximum after 6 months. At this time the epithelial cells, particularly the non-ciliated cells were almost devoid of organelles and had an electron transparent cytoplasm. In addition to the action of lynestrenol on the secretory and synthetic activities of the cells a strong ciliogenetic effect could be observed after about 3 months of lynestrenol administration. The ratio of ciliated to non-ciliated cells changed from 1∶1 at the beginning of the treatment to 2.9∶1 after 6 months. This ratio was then maintained and could still be found in patients who had used lynestrenol for 25 and 39 months. In contrast to the persistent effect of lynestrenol on the ciliary apparatus of the cells the synthetic activities and the secretory mechanism were partially restored with long standing use. The importance of the observed changes and their possible participation in the contraceptive action of lynestrenol are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00667367
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  • 6
    Electronic Resource
    Electronic Resource
    Die Dezidualisation der endometrialen Stromazelle (1977)
    Springer
    Archives of gynecology and obstetrics 223 (1977), S. 19-31 
    Details
    ISSN: 1432-0711
    Keywords: Stromal reticulum cell ; Decidua ; Ultrastructure ; Stroma-Retikulumzelle ; Deziduale Umwandlung ; Feinstruktur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In der vorliegenden Arbeit werden die feinstrukturellen Veränderungen der endometrialen Stroma-Retikulumzelle über die prädeziduale Reaktion der späten Sekretionsphase bis hin zur ausdifferenzierten Deziduazelle beschrieben. Bei der dezidualen Umwandlung der Retikulumzellen ändern sich Zellvolumen, Organellensortiment und zwischenzellige Beziehungen. Die Veränderungen sind Ausdruck eines adaptativen Funktionswandels der Zellen. Im Gegensatz zur kontinuierlichen Transformation der Feinstruktur zeigt das zytochemische Verhalten eine in Schüben ablaufende Entwicklung, da die neugewonnenen Enzymmuster jeweils erst nach der funktionellen Reifung ihrer Arbeitsstrukturen erfaßt werden können. Zu den wichtigsten zellspezifischen Leistungen der Deziduazelle und ihrer Vorstadien gehören sekretorische und intermediäre endokrine Aufgaben. Als spezifisches Sekretionsprodukt der Stroma-Retikulum- und Deziduazelle lassen sich präkollagene Fibrillen nachweisen. Für eine Beteiligung der Deziduazelle am Steroidmetabolismus sprechen charakteristische Organellenveränderungen, die im zeitlichen Zusammenhang mit Steroiddehydrogenaseaktivitäten auftreten. Ein auffallender Befund der postovulatorischen Retikulumzelle und der voll entwickelten Dezidua sind spezielle Differenzierungen des Karyoplasma (Karyosome). Äahnliche nukleäre Differenzierungen sind auch von anderen Zellen hormonsensitiver Gewebe bekannt. Sie könnten als sichtbare Manifestation der am genetischen Apparat des Kernes angreifenden Steroidhormonwirkung gedeutet werden.
    Notes: Summary The fine structural changes of the endometrial stromal cell from late secretory phase up to full developed decidua cell have been investigated by means of electron microscope. During decidual transformation the cell volume, the assortment of cytoplasmic organelles and the mode of intercellular attachments undergo characteristic alterations. These alterations reflect an adaptation on new cellular functions. In contrast to the structural organization, which is transformed continuously, the encymatic cell pattern exerts a step wise gradual transformation, since new encymatic capacities can only arise after their functional structures have been established. To the most important functions of decidua cells and their prestages belong secretory and endocrine activities. Precollagen fibrills represent a specific secretory product of the stroma reticulum cells. The active involvement of the full differentiated decidua cells in steroid metabolism is indicated by characteristic transformations of the cytoplasmic organization concomittantly to the appearance of intracellular steroid dehydrogenase activities. So-called karyosoma could be demonstrated within the nuclei of postovulatory stromal reticulum cells as in decidua cells. Similar nuclear differentiations have been observed in various target cells of steroid hormones. They possibly are structural manifestations of the hormonal interaction with the nuclear DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00675080
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  • 7
    Electronic Resource
    Electronic Resource
    Coquille de l'oeuf de caille: Étude ultrastructurale et cristallographique (1978)
    Springer
    Calcified tissue international 25 (1978), S. 145-159 
    Details
    ISSN: 1432-0827
    Keywords: Bird egg shell ; Ultrastructure ; Calcification ; Electron diffraction ; Microanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The egg-shell of Japanese quail was studied by several techniques. Semithin sections (1μm thick) of non-decalcified shell were observed by normal and polarized light microscopy. Thin sections of non-decalcified shell, examined by transmission electron microscopy, permitted us to observe the forms and dimensions of crystals of calcite within different layers of the shell: mammilary layer, layer of cones, palissade layer and surface crystal layer. There appears to be two distinct zones in the layer of cones as well as in the superficial crystal layer. Electron microdiffraction revealed the orientation of calcite crystals in the columns. Some crystal defects (twins?) were described and the possibility of their artefactual formation during ultramicrotomy is discussed. Localization of Ca, Mg, P and S were made by X-ray microanalysis of semithin sections. This technique shows that shell membranes, and chiefly the true cuticle, are also mineralized but, in these layers, minerals are not crystallized. Otherwise the distribution of Mg is not uniform throughout the shell thickness; it is less concentrated in the external zone of the layer of cones. These results together with observation of developing shells by scanning electron microscopy allowed us to propose a scheme for shell organization of the quail egg. This organization was related with decalcification which occurs during hatching.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02010763
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  • 8
    Electronic Resource
    Electronic Resource
    Ultrastructural and microanalytical aspects of developing osteodentin in rat incisors (1977)
    Springer
    Calcified tissue international 24 (1977), S. 215-222 
    Details
    ISSN: 1432-0827
    Keywords: Mineralization ; Osteodentin ; Intracellular ; Ultrastructure ; Microanalysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Newly formed osteodentin obtained from the anterior extremities of fetal or young rat incisors was observed by means of electron microscopy and electron probe X-ray microanalysis. Cells related to osteodentin formation frequently showed membrane bound intracellular bodies containing varying amounts of fine, needle-shaped crystals, which were identified as apatite. The intracellular clusters of apatite crystals were extruded from the cells through membrane fusion or cellular degeneration. These extracellular clusters seemed to be gradually incorporated into the mineralizing collagenous matrix, which developed around them. Frequent occurrence of dense, dotshaped or filamentous profiles suggested that the dense bodies seen in the perinuclear regions or in the Golgi area were the sites of crystal formation. Energy dispersive X-ray point analysis showed that the intracellular or extracellular apatite clusters contained sulfur in a concentration higher than was present in the mineralizing collagenous matrix. Furthermore, wave dispersive X-ray line analysis showed that the concentration of sulfur was higher in the osteodentin matrix than in the dentin matrix. The sulfur detected is presumed to be contained in acid mucopolysaccharides, which were distributed more heavily in the osteodentin matrix than in the dentin matrix. On the basis of these data, it was concluded that the unique chemical and structural characteristics of the osteodentin result primarily from the incorporation of apatite clusters of intracellular origin and associated acid mucopolysaccharides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02223319
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  • 9
    Electronic Resource
    Electronic Resource
    Studies on the biology of fish bone. III. Ultrastructure of osteogenesis and resorption in osteocytic (cellular) and anosteocytic (acellular) bones (1979)
    Springer
    Calcified tissue international 28 (1979), S. 43-56 
    Details
    ISSN: 1432-0827
    Keywords: Bone resorption ; Osteogenesis ; Fish bone ; Osteocytes ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The comparative ultrastructure of fish bone osteogenesis and resorption induced by scale removal was described in the osteocytic (cellular-boned)Carassius auratus and the anosteocytic (acellular-boned)Tilapia macrocephala. Osteocytes, present in osteocytic bone, were lacking in anosteocytic bone. In osteocytic bone the osteoblast secreted a collagenous preosseous matrix in which it became enmeshed and then was termed a preosteocyte. When the preosseous matrix mineralized, the preosteocyte was termed an osteocyte and was completely surrounded by bone. In anosteocytic bone the osteoblasts receded from the mineralizing front and never became trapped as osteocytes. During resorption, types A and B resorptive cells, present in both bone types, invaded the matrix and demineralized the osseous zone. These cells were characterized by large amounts of granular endoplasmic reticulum and intracellular inclusions containing crystal-like material. Although functionally similar to mammalian osteoclasts, these cells lacked a characteristic ruffled border and were not multinucleated. The osteocytes of cellular bone did not appear to be involved during demineralization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02441217
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  • 10
    Electronic Resource
    Electronic Resource
    Quantitative ultrastructural observations on the inhibited recovery of the hypoglossal nucleus from the axotomy response when regeneration of the hypoglossal nerve is prevented (1976)
    Springer
    Experimental brain research 26 (1976), S. 141-150 
    Details
    ISSN: 1432-1106
    Keywords: Rat ; Hypoglossal nucleus ; Inhibited regeneration ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Electron micrographs of the left hypoglossal nucleus were quantitatively analyzed in adult rats 52 to 98 days after transection of the left hypoglossal nerve and implantation of the proximal stump into the already innervated ipsilateral sternomastoid muscle, a procedure which prevented the transected nerve from regenerating. Many presynaptic boutons with clear spherical synaptic vesicles and symmetrical synapses were lost from the injured perikarya and dendrites. Some perikarya and dendrites (and, rarely, boutons) became electron dense, and astrocyte or microglial sheaths partly surrounded them. Numbers of dendrite profiles in the neuropil decreased. These statistically significant effects persisted throughout the postoperative period, whereas after axotomy with unimpeded nerve regeneration, these features would have returned to normal by 84 days postoperatively. It was therefore suggested that their recovery depended upon successful regeneration and reconnection of the hypoglossal nerve with the tongue. Subsurface cisterns, and profiles containing unusual inclusions, were numerically normal 52 to 98 days postoperatively, so it was suggested that their early response and recovery after simple axotomy might be entirely dependent on nerve disconnection and not on nerve reconnection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238278
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