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  • Mouse  (138)
  • Springer  (138)
  • 1980-1984  (138)
Document type
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Year
  • 1
    Electronic Resource
    Electronic Resource
    The effect of N-methyl-formimino-methylester on the neural olfactory threshold in albino mice (1984)
    Springer
    European archives of oto-rhino-laryngology and head & neck 239 (1984), S. 25-29 
    Details
    ISSN: 1434-4726
    Keywords: Olfactory threshold ; Olfactory blockade ; N-methyl-formimino-methylester ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of N-methyl-formimino-methylester were studied in albino mice. Very short exposure (0.5 and 1 s) to the concentrated vapour led to an increase of the neural olfactory threshold to geraniol by a factor of 105–107. There was a slow recovery of the olfactory sensitivity and after about 40 days the threshold values returned to normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00454259
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  • 2
    Electronic Resource
    Electronic Resource
    Proliferationsstimulation des Gallenblasenepithels durch lithogene Diät (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 197-198 
    Details
    ISSN: 1432-1440
    Keywords: Lithogenic diet ; Cellproliferation ; Tritiated thymidine ; Gallbladder epithelial cells ; Mouse ; Nucleating factors ; Gallstones ; Lithogene Diät ; Zellproliferation ; 3H-Thymidin ; Gallenblasenepithel ; Maus ; Kristallisationskern ; Gallensteine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Zusatz von Cholesterin und Cholsäure zur üblichen Haltungsdiät verursacht bei Mäusen nach 6–8wöchiger Fütterungszeit Gallensteine. Bereits lange vor der Steinbildung sind histologisch Veränderungen des Gallenblasenepithels zu registrieren, insbesondere fällt die Zunahme der Proliferation auf. Autoradiographische Untersuchungen zeigten im Verlauf experimenteller Gallensteinerzeugung gehäuft oberflächlich im Epithel gelegene markierte Mitosen. Um auszuschließen, daß dies eine zufällige Beobachtung war, wurden Mitosen mit Vincristin unter gleichzeitiger Markierung mit3H-Thymidin arretiert. Danach fanden sich vermehrt markierte Mitosen und Interphasenkerne an der Oberfläche des Epithels. Teilweise schilferten diese Zellen bereits ins Lumen der Gallenblase ab. Sie könnten als mögliche Kristallisationskerne für die Steininduktion Bedeutung haben.
    Notes: Summary Mice fed a diet containing 1% cholesterol and 0.5% cholic acid develop gallstones within six or eight weeks. Experimental lithogenesis initiates an increase in the proliferative activity of epithelial cells in the gallbladder well before the appearence of gallstones. During the initial stages of experimental cholelithiasis an increase in the number of labelled (tritiated thymidine) nuclei in mitosis and in the DNA-synthetic period was found. The labelled nuclei were observed particularly on the epithelial surface of the gallbladder; many of them were about to exfoliate into the lumen. These data were confirmed by applying vincristine. We would suggest that the rapid exfoliation of the proliferating cells could be one of the nucleating factors that promote gallstones formation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01477480
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  • 3
    Electronic Resource
    Electronic Resource
    Behavioural effects of phenobarbitone II. Effects in nursing female mice (1983)
    Springer
    Psychopharmacology 81 (1983), S. 252-257 
    Details
    ISSN: 1432-2072
    Keywords: Phenobarbitone ; Chronic administration ; Pup development ; Maternal behaviour ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phenobarbitone supplied at concentrations of 187.5 mg/l and 500 mg/l (50–60 mg/kg and 120–190 mg/kg daily) in the drinking fluid of mice throughout pregnancy and lactation did not affect gestation period, numbers born or resorbed or pup weights at birth and weaning. The higher dose caused significant retardation in eye-opening, development of forelimb extension, negative geotaxis, in appearance of washing and self-grooming behaviours and in cessation of suckling. The lower dose had no detectable effects. Ethological methods were used to examine spontaneous behaviour of nursing dams within home cages on days 1, 7, 14 and 21 postpartum. Treated dams showed differences in behaviour from controls, the most marked of which were increased levels of Maternal Behaviour and decreases in Non-Social Activity in the high-dose group at day 1, and continuance of pup Nursing in both treated groups and Nest Building in the high-dose group at day 21 when controls were ceasing these behaviours. At 21 days all treated dams also showed less Immobility than controls and high-dose dams a smaller amount of pup Social Investigation. Many behavioural differences at 21 days were related to developmental delay of treated pups. Overall, phenobarbitone did not impair maternal care.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427273
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  • 4
    Electronic Resource
    Electronic Resource
    Regional calcium levels in rat and mouse brain: automated fluorimetric assay and effects of centrally acting drugs (1983)
    Springer
    Psychopharmacology 81 (1983), S. 275-280 
    Details
    ISSN: 1432-2072
    Keywords: Ca2+ ; Brain Ca2+ ; Lithium ; Kainic acid ; Cold stress ; Sleep deprivation ; Antidepressants ; Neuroleptics ; Morphine ; Naloxone ; Ethanol ; Reserpine ; Tetrodotoxine ; Mercaptopropionic acid ; Pentobarbital ; Chlordiazepoxide ; Mouse ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abtract The effects of several drugs and other treatments on the regional levels of Ca2+ in the brain of mice and rats were determined with an automated assay, based on the formation of a fluorescent calcein complex in a continuous flow system. The method is linear (between 1.5 and 5 μg Ca2+ ml-1), specific (no other cations present in the brain showed fluorescence) and sensitive (10–100 mg brain tissue can be analyzed). No major effects with the following drugs, given once or repeatedly to mice at high doses were found: morphine, naloxone, haloperidol, sulpiride, chlordiazepoxide, reserpine, ethanol, mercaptopropionic acid, or pentobarbital. Cold stress produced a transient increase in the regional levels of Ca2+ in the mouse brain. Lithium sulphate produced a small increase of brain Ca2+ 24 h after a high and toxic dose. Sleep deprivation for 24 h was ineffective in these experiments. Local application of kainic acid and tetrodotoxine to the rat striatum had no acute effects, but kainic acid produced a five to tenfold increase in the levels of striatal Ca2+ 2 weeks after injection. The present study does not support earlier published findings, which suggested that several behaviourally active drugs produce significant decreases of brain Ca2+. Morever, it provides no evidence that the several therapeutic treatments that resulted in changes in body fluid Ca2+ also alter cerebral levels of Ca2+. On the other hand, the present data do suggest that damage to nervous tissue substantially influences Ca2+ metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427562
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  • 5
    Electronic Resource
    Electronic Resource
    The effect of low doses of d-amphetamine on drug-induced hyperactivity in the mouse (1983)
    Springer
    Psychopharmacology 81 (1983), S. 327-331 
    Details
    ISSN: 1432-2072
    Keywords: Locomotor activity ; Amphetamine ; Serotonin ; γ-Butyrolactone ; Benztropine ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of low doses (7.5–250 μg/kg) of d-amphetamine was studied on benztropine- or γ-butyrolactone-induced hyperactivity in the mouse. Amphetamine 30–125 μg/kg significantly attenuated the drug-induced hyperactivity. This effect was antagonised by both cinanserin and p-chlorophenylalanine. The results suggest that low doses of d-amphetamine release 5-hydroxytryptamine, which in turn has an inhibitory effect on locomotor activity. This effect was masked at higher doses of d-amphetamine due to a release of dopamine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427571
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  • 6
    Electronic Resource
    Electronic Resource
    Value of an animal model for trisomy (1982)
    Springer
    Virchows Archiv 395 (1982), S. 117-131 
    Details
    ISSN: 1432-2307
    Keywords: Man ; Mouse ; Developmental genetics ; Monosomy ; Trisomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Problems related to the developmental pathology of fetal aneuploidy are amenable to systematic investigation in a mouse model of autosomal trisomy. With a breeding design of one parent doubly heterozygous for two partially homologous Robertsonian metacentrics, some of the monosomies and all nineteen trisomies of the mouse can be studied. Monosomies are eliminated either before or shortly after implantation. Some trisomies do not survive a first critical phase of organogenesis on days 11 to 12 of fetal development, others such as Ts 12 to 14, 16, 18, and 19 have a lifespan until or beyond birth. A critical situation of long duration is caused in late development by hypoplasia of the placental labyrinth and ensuing impairment of metabolic exchange and of oxygen supply to the fetus. Model type morphogenetic analyses of anomalies (e.g. cranio-cerebral, cardio-vascular), are possible in Ts 1, 12, 14, 19, and others, and Ts 16 of the mouse is considered to be a close and natural model of human trisomy 21. The eventual breakdown and death of the aneuploid organism is inevitable. However, the introduction of monosomic or the transfer of trisomic haemopoietic stem cells to irradiated recipients is a means of rescuing the aneuploid cells and tissues with longer survival. Under these conditions isolated trisomic haemapoiesis can show almost complete and near-normal maturation, at least in trisomies 12 and 19. In other trisomies (e.g., 13 and 16) stem cell defects impair such reconstitution. The experimental induction of mouse aneuploidy is a powerful technique which allows us to fill gaps in our existing knowledge of human trisomy, and suggests new lines of research. These are the major benefits of an experimental model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429606
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  • 7
    Electronic Resource
    Electronic Resource
    The effect of caffeine, theophylline and amphetamine on operant responding of the mouse (1980)
    Springer
    Psychopharmacology 68 (1980), S. 135-138 
    Details
    ISSN: 1432-2072
    Keywords: Amphetamine ; Caffeine ; Mouse ; Rate dependency ; Theophylline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Caffeine, theophylline and d-amphetamine were administered to three mice responding on a multiple fixed-interval (FI) 10 min, fixed-ratio (FR) 30 schedule for evaporated milk. All three drugs increased FI rates of responding at nearly the same molar dose with amphetamine being the most effective, followed by theophylline and then caffeine. While intermediate doses of amphetamine severely decreased FR rates of responding, the same dose caused large increases in FI rates of responding. With the methylxanthines, both FI and FR rates were decreased by the same high dose. It was concluded that the effects of caffeine and theophylline resemble each other and differ from amphetamine with the schedules tested. The effects of all three drugs were rate dependent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432130
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  • 8
    Electronic Resource
    Electronic Resource
    Voluntary ethanol consumption after ethanol and acetaldehyde treatment in alcohol-preferring C57BL mice (1982)
    Springer
    Psychopharmacology 78 (1982), S. 361-364 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Acetaldehyde ; Liver alcohol dehydrogenase ; Alcohol preference ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract C57BL mice normally show a preference for alcohol solutions compared with water. The effect of chronic, ethanol treatment sufficient to produce behavioural tolerance on the voluntary ethanol consumption of C57BL mice was compared with the effect of acute ethanol and acute and chronic administration of acetaldehyde. Chronic treatment with ethanol caused a loss of preference which lasted more than 12 weeks after withdrawal from the treatment. The acute ethanol treatment and the acute and chronic acetaldehyde treatments only produced a transient loss of preference which returned to normal within 1 week of cessation of treatment. The effect of these drugs on liver alcohol dehydrogenase (LAdH) was also examined. Changes in LAdH activity did not correlate with alcohol preference. Possible reasons for the different effects of the drug treatments on alcohol preference are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433742
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  • 9
    Electronic Resource
    Electronic Resource
    Behavioural effects of phenobarbitone (1983)
    Springer
    Psychopharmacology 79 (1983), S. 155-160 
    Details
    ISSN: 1432-2072
    Keywords: Phenobarbitone ; Teratogenic effects ; Growth ; Development ; Exploratory behaviour ; Social behaviour ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Phenobarbitone at a concentration of 187.5 mg/l in drinking fluid of breeding mice and their offspring after weaning did not affect gestation period, litter size, litter weight or pup development before weaning, although a slight retardation of weight gain after weaning occurred. This level of phenobarbitone given to mice after weaning did not affect weight gain. The average daily intake of phenobarbitone ranged from 30 to 52 mg/kg body weight depending on age and sex. Behaviour of offspring and mice treated after weaning was examined by ethological analysis of encounters between unfamiliar mice of the same sex and treatment group in a neutral enclosure. After lifelong exposure to phenobarbitone mice at 5 and 15 weeks of age showed an increased amount of scanning and exploration of the unfamiliar cage coupled with a decrease of time spent in immobility. Difference from control levels was more pronounced at 15 than at 5 weeks of age, in part because controls showed more immobility and explored less as they matured. No behavioural changes were detected in mice treated with this level of phenobarbitone after weaning. Lifelong exposure to phenobarbitone did not affect agonistic behaviour in pair-housed males at 30 weeks of age, and under these circumstances no longer stimulated exploration to a significant extent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427803
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  • 10
    Electronic Resource
    Electronic Resource
    Tolerance to the anti-pentylenetetrazole effects of diazepam in the mouse (1983)
    Springer
    Psychopharmacology 79 (1983), S. 284-286 
    Details
    ISSN: 1432-2072
    Keywords: Diazepam ; Pentylenetetrazole ; Picrotoxin ; Convulsions ; Myoclonus ; Tolerance ; Mouse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The protective effects of acute and chronic diazepam administration (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) and picrotoxin were investigated. Considering the incidence of tonic-clonic convulsions, tolerance to the protective effects of diazepam was evident by day 5 if the mice were challenged with PTZ (120 mg/kg), by day 10 if the challenge was picrotoxin (8 mg/kg) and by day 20 if the challenge was PTZ (105 mg/kg). Diazepam retained its protective effects against tonic-clonic convulsions induced by PTZ (90 and 60 mg/kg) for 45 days, but the incidence of myoclonic jerks revealed tolerance after 5 days.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427828
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