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  • 1
    Digitale Medien
    Digitale Medien
    The pressor hyperresponsiveness to phenylephrine unmasks sympathetic hypofunction in migraine (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The pressor responsiveness to phenylephrine, an almost pure agonist of peripheral alpha-1-adrenoceptors, was studied in 32 migraine patients in headache-free intervals. Eighteen healthy volunteers served as a control group. Fourteen patients and 14 controls also underwent the tilt test. The following observations were made: (1) the pressor response to phenylephrine was significantly greater and longer lasting in patients than in controls; (2) the reflex decrease of heart rate did not differ in the two groups; (3) a normal orthostatic increase of blood pressure and heart rate occurred in migraineurs with hyperresponsiveness to phenylephrine. These findings suggest a supersensitivity of vascular adrenoceptors which is compatible with a chronic adrenergic deficiency in migraineurs. Since patients did not show an orthostatic hypotension in attack-free periods, the compensatory character of receptoral supersensitivity and the possible mechanisms of cardiovascular dysautonomia, which may occur during migraineous attack, were discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0904239.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    A case of parasellar meningioma mimicking cluster headache (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: A medical history of a 46-year-old male is reported. At 23 years of age, he started having diffuse pain in the left side of his head for up to 30 min once or twice a month. At 28, the pain changed into left-sided cluster headache-like attacks with 2–3 h duration and with ipsilateral conjunctival injection, lacrimation, and rhinnorhea, but with short-lasting free intervals of about two to three weeks. At 36, the pattern of the attacks corresponded to chronic migrainous neuralgia. At 40, the symptoms changed to painful ophthalmoplegia-picture. A left-sided parasellar meningioma was then diagnosed. Removal of the tumor caused complete amelioration. The case history is suggested to support the hypothesis that the cavernous sinus region is involved in cluster headache.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0904265.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Effects of prostanoids on human and rabbit basilar arteries precontracted in vitro (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: The effect of a range of prostanoids on human and rabbit basilar arteries precontracted in vitro in the presence of the thromboxane receptor-blocking drug AH23848B was investigated. On the rabbit basilar artery and in the presence of AH23848B the thromboxane A2 mimetic U-46619 produced further concentration-related contractions of the tissue. All other prostaglandins (except ICI81008 and PGF2a which had no effect) produced concentration-related relaxations with the rank order of relaxant potency being PGE2 〉 Iloprost 〉 PGI2 = PGE1 = 16,16-dimethyl PGE2 = PGD2. On the human basilar artery PGI2 and iloprost produced concentration-related relaxations with iloprost being more potent than PGI2. At high concentrations both these compounds produced reduced relaxant responses. All other prostanoids (except ICI81008 and PGD2 which had no effect) contracted the tissue, the rank order of contractile potency being 16, 16-dimethyl PGE2 〉 PGE2 〉 PGF2a = PGE1 〉 U46619 〉〉 ICI81008 and PGD2. It is concluded that the human basilar artery possesses two contractile prostanoid receptors, a TP receptor and one which may be of the EP-type in addition to a prostanoid receptor mediating relaxation which may be of the IP-type. The prostanoid receptor(s) mediating relaxation of the rabbit in vitro basilar artery is difficult to determine. The relevance of the observations to cerebrovascular disorders such as migraine and vasospasm is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0903165.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Cluster headache: increased incorporation of (1-14C)arachidonic acid into phosphatidylserine in polymorphonuclear cells (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Vasoactive metabolites deriving from arachidonic acid (AA) have been considered as putative mediators in the pathogenesis of various types of headache. In the present study we therefore compare the ability to synthesize AA containing precursor phospholipids in polymorphonuclear cells (PMNs) from healthy controls and cluster headache patients. 3.7% ± 1.4 (mean ± SD) of the (1-14C)AA incorporated into total PMN glycerophospholipids (GPLs) was recovered in the phosphatidylserine (PS) in a group of cluster headache patients (n = 12). This was almost twice the value of 1.9% ± 0.8% found in a corresponding group of 24 healthy controls (p 〈 0.001). A significant decrease in the incorporation of (1-14C)AA into phosphatidylcholine (PC) (p 〈 0.01) and an increase in the incorporation of (1-14C)AA into phosphatidyletanolamine (PE) (p 〈 0.05) were also found in cluster headache patients when compared to the control group. The increased incorporation of (1-14C)AA into PS in PMNs from this group of patients is interesting because PS plays an important role in the activation of protein kinase C, an enzyme involved in transmembrane signalling. The clinical implications of the present findings in cluster headache, if any, cannot yet be defined.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0903213.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    The significance of age, sex, and cerebrospinal fluid pressure in post-lumbar-puncture headache (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: In this study of 300 neurological inpatients aged between 18 and 60 years the incidence of post-lumbar-puncture headache (PPH) was 37.3%. The more severe the headache, the more frequently it was associated with dizziness, nausea, vomiting, and tinnitus. If PPH occurred during the first day after lumbar puncture (LP), it was more severe, and lasted longer than PPH, which started later. The incidence of PPH and associated symptoms decreased with increasing age, and was much higher in females than males. The sex difference was nearly exclusively explained by a marked preponderance of PPH in females below 40 years of age, i.e. women in the fertile age. Furthermore, there was a decreased incidence of PPH and associated symptoms in patients with an initial higher than average cerebrospinal fluid (CSF) pressure (162 mm H2O). All these differences were statistically significant. Particularly high frequencies of PPH were found in young women with an initial CSF pressure lower than mean.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0902099.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Hemicranial attacks or permanent hemicrania — a sequel of upper cervical root compression (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: After many years of unsuccessful conservative treatment 16 patients suffering from hemicrania are relieved of their pain or are improved by operative treatment. Hemicranial attacks or permanent hemicrania is found to be caused by upper cervical nerve root compression. Vascular compression of C2 (n = 9) or scar tissue surrounding C2 (n = 1) or C3 (n = 1) is the pathology identified in cases of cervicogenic headache or “cluster headache-like” headache. Compression attributable to tumor, prolapsed disc, or spondylotic changes is found to be a cause of permanent headache. Only in those patients with permanent headache are radiological or electrophysiological findings helpful for diagnosis. In patients with hemicranial attacks and compression of nerve root C2 (n = 10) or C3 (n = 1), only vasoactive tests (provoking or relieving pain) or local anaesthesia prove to be helpful in diagnosing and localizing the origin of pain. The operation involves freeing the nerve roots from vascular compression. In two patients the C2 ganglion is resected. Thirteen patients subsequently become pain free. In three patients, hemicrania improves. Four of the 16 patients experience a recurrence of pain after the decompressive operation. After additional thermorhizotomy two patients have no further complaints and one patient has improved. One patient can tolerate his pain with occasional analgesics. The problem of referred pain into the fronto-ocular region is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0902123.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Platelet catecholamines in migraine (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: We measured platelet levels of norepinephrine (NE), epinephrine (E), and dopamine (DA) in migraine patients. Platelet NE was selectively increased in common migraine. This is attributed to platelet dense body hyposecretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0901003.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Double-blind study of naproxen vs placebo in the treatment of acute migraine attacks (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Naproxen was compared with placebo in a double-blind, crossover trial in classic and common migraine. The trial was terminated at a fixed date; 37 patients had entered, 5 of whom were excluded. Naproxen was given as 750 mg at the first symptom of the attack, a total of 1250 mg per 24 h was allowed. Patients were followed for six attacks or three months in each phase, whichever came first. The severity of the headache was significantly less with naproxen in the first 2 h of the attack (p=0.047), whereas there was no difference when the whole attack was considered. Significantly more patients preferred naproxen (p=0.042). Side effects occurred in five patients, causing withdrawal of one patient while on naproxen.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0901029.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Variants of chronic paroxysmal hemicrania; a reply to Seymour Solomon (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0901078-2.x
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Cluster headache: Combined assessment with pupillometry and evaporimetry (1989)
    USA/Oxford, UK : Blackwell Science Ltd
    Cephalalgia 9 (1989), S. 0 
    Details
    ISSN: 1468-2982
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1046/j.1468-2982.1989.0901078-3.x
    Standort Signatur Einschränkungen Verfügbarkeit
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