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  • Elsevier  (1)
  • Nature Publishing Group (NPG)  (1)
  • 2010-2014  (2)
  • 1
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    Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-12-04
    Description: Article Hereditary hypertrophic cardiomyopathy (HCM) is caused by mutations in cardiomyocyte genes, such as MYBPC3 . Here, the authors use virus-mediated gene therapy to correct Mycbpc3 mutations in 1-day-old mice and, by administering just a single dose, prevent development of HCM over a period of 34 weeks. Nature Communications doi: 10.1038/ncomms6515 Authors: Giulia Mearini, Doreen Stimpel, Birgit Geertz, Florian Weinberger, Elisabeth Krämer, Saskia Schlossarek, Julia Mourot-Filiatre, Andrea Stoehr, Alexander Dutsch, Paul J. M. Wijnker, Ingke Braren, Hugo A. Katus, Oliver J. Müller, Thomas Voit, Thomas Eschenhagen, Lucie Carrier
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Assessment of DNA synthesis in Islet-1+ cells in the adult murine heart (2014)
    Elsevier
    Details
    Publication Date: 2014-11-28
    Description: Publication date: Available online 24 November 2014 Source: Biochemical and Biophysical Research Communications Author(s): Florian Weinberger , Dennis Mehrkens , Jutta Starbatty , Philipp Nicol , Thomas Eschenhagen Rationale: Islet-1 positive (Islet-1 + ) cardiac progenitor cells give rise to the right ventricle, atria and outflow tract during murine cardiac development. In the adult heart Islet-1 expression is limited to parasympathetic neurons, few cardiomyocytes, smooth muscle cells, within the proximal aorta and pulmonary artery and sinoatrial node cells. Its role in these cells is unknown. Here we tested the hypothesis that Islet-1 + cells retain proliferative activity and may therefore play a role in regenerating specialized regions in the heart. Methods and results: DNA synthesis was analyzed by the incorporation of tritiated thymidine ( 3 H-thymidine) in Isl-1-nLacZ mice, a transgenic model with an insertion of a nuclear beta-galactosidase in the Islet-1 locus. Mice received daily injections of 3 H-thymidine for 5 days. DNA synthesis was visualized throughout the heart by dipping autoradiography of cryosections. Colocalization of an nLacZ-signal and silver grains would indicate DNA synthesis in Islet-1 + cells. Whereas Islet − non-myocyte nuclei were regularly marked by accumulation of silver grains, colocalization with nLacZ-signals was not detected in >25,000 cells analyzed. Conclusions: Islet-1 + cells are quiescent in the adult heart, suggesting that, under normal conditions, even pacemaking cells do not proliferate at higher rates than normal cardiac myocytes.
    Print ISSN: 0006-291X
    Electronic ISSN: 1090-2104
    Topics: Biology , Chemistry and Pharmacology , Physics
    Published by Elsevier
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