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  • 1995-1999  (2)
  • 1990-1994
  • 1995  (2)
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  • 1995-1999  (2)
  • 1990-1994
Year
  • 1
    Electronic Resource
    Electronic Resource
    Accelerated Structural Maturation Induced by Synapsin I at Developing Neuromuscular Synapses of Xenopus laevis (1995)
    Oxford, UK : Blackwell Publishing Ltd
    European journal of neuroscience 7 (1995), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The role of synapsin I, a synaptic vesicle-associated phosphoprotein, in the maturation of nerve–muscle synapses was investigated in nerve–muscle co-cultures prepared from Xenopus embryos loaded with the protein by the early blastomere injection method. The stage of maturation of the synapses was analysed by electron microscopy as well as by whole-cell patch-clamp recording. The acceleration in the functional maturation of neuromuscular synapses induced by synapsin I was accompanied by a profound rearrangement in the ultrastructure of the nerve terminal. Nerve terminals formed by synapsin I-loaded neurons were characterized by a higher number of small synaptic vesicles organized in clusters and predominantly localized close to the nerve terminal plasma membrane, a smaller number of large dense-core vesicles and no significant change in the number of coated vesicles. Precocious development of active zone-like structures as well as deposition of basal lamina into the synaptic cleft were also observed at these synapses. These results support a role for synapsin I in the architectural changes which occur during synaptogenesis and lead to the maturation of quantal neurotransmitter release mechanisms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1460-9568.1995.tb01062.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses (1995)
    [s.l.] : Nature Publishing Group
    Nature 374 (1995), S. 262-266 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Synaptic currents were monitored on single innervated myocytes by whole-cell voltage-clamp recordings in 1-day-old nerve-muscle cultures prepared from Xenopus embryos16. We first examined the effects of the NO donor, S-nitroso-7V-acetyl-penicilamine (SNAP)17, on spontaneous synaptic currents ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/374262a0
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    Paper (German National Licenses)
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