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  • Articles  (27)
  • Nature Publishing Group (NPG)  (23)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (4)
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  • Articles  (27)
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  • 1
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    AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages (2015)
    Nature Publishing Group (NPG)
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    Publication Date: 2015-08-14
    Description: AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages Cell Death and Disease 6, e1856 (August 2015). doi:10.1038/cddis.2015.211 Authors: E Six, C Lagresle-Peyrou, S Susini, C De Chappedelaine, N Sigrist, H Sadek, M Chouteau, N Cagnard, M Fontenay, O Hermine, C Chomienne, P Reynier, A Fischer, I André-Schmutz, N Gueguen & M Cavazzana
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 2
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    Reduced-dimensionality-induced helimagnetism in iron nanoislands (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-10-24
    Description: Article Spin textures, such as skyrmions, could be useful in future low-power-consumption memory devices, but they are usually only seen in materials with a strong spin-orbit interaction. Phark et al. now, however, observe such non-collinear magnetic order in nanometre-scale bilayer iron islands. Nature Communications doi: 10.1038/ncomms6183 Authors: S. -H. Phark, J. A. Fischer, M. Corbetta, D. Sander, K. Nakamura, J. Kirschner
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    In situ soft XAS study on nickel-based layered cathode material at elevated temperatures: A novel approach to study thermal stability (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-10-30
    Description: Tracking thermally induced reactions has always been challenging for electrode materials of electrochemical battery systems. Traditionally, a variety of calorimetric techniques and in situ XRD at elevated temperatures has been used to evaluate the thermal stability of electrode materials. These techniques are capable of providing variations in heat capacity, mass and average bulk composition of materials only. Herein, we report investigation of thermal characteristics of Li0.33Ni0.8Co0.15Al0.05O2 by using in situ soft XAS measurements in combination with XRD. Fluorescence yield and partial electron yield measurements are used simultaneously to obtain element selective surface and bulk information. Fluorescence yield measurements reveal no energy change of the absorption peak and thus no valence state change in the bulk. However, electron yield measurements indicate that NiO-type rock salt structure is formed at the surface at temperatures above 200°C while no evidence for a surface reaction near Co sites in investigated temperature range is found. These results clearly show that in situ soft XAS can give a unique understanding of the role of each element in the structural transformation under thermal abuse offering a useful guidance in developing new battery system with improved safety performance. Scientific Reports 4 doi: 10.1038/srep06827
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Nature Publishing Group (NPG)
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  • 4
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    Self-homodyne measurement of a dynamic Mollow triplet in the solid state (2016)
    Nature Publishing Group (NPG)
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    Publication Date: 2016-02-27
    Description: Nature Photonics 10, 163 (2016). doi:10.1038/nphoton.2015.276 Authors: Kevin A. Fischer, Kai Müller, Armand Rundquist, Tomas Sarmiento, Alexander Y. Piggott, Yousif Kelaita, Constantin Dory, Konstantinos G. Lagoudakis & Jelena Vučković The study of the light–matter interaction at the quantum scale has been enabled by the cavity quantum electrodynamics (CQED) architecture, in which a quantum two-level system strongly couples to a single cavity mode. Originally implemented with atoms in optical cavities, CQED effects are now also observed with artificial atoms in solid-state environments. Such realizations of these systems exhibit fast dynamics, making them attractive candidates for devices including modulators and sources in high-throughput communications. However, these systems possess large photon out-coupling rates that obscure any quantum behaviour at large excitation powers. Here, we have used a self-homodyning interferometric technique that fully employs the complex mode structure of our nanofabricated cavity to observe a quantum phenomenon known as the dynamic Mollow triplet. We expect this interference to facilitate the development of arbitrary on-chip quantum state generators, thereby strongly influencing quantum lithography, metrology and imaging.
    Print ISSN: 1749-4885
    Electronic ISSN: 1749-4893
    Topics: Physics
    Published by Nature Publishing Group (NPG)
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  • 5
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    Coherent control with a short-wavelength free-electron laser (2016)
    Nature Publishing Group (NPG)
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    Publication Date: 2016-02-27
    Description: Nature Photonics 10, 176 (2016). doi:10.1038/nphoton.2016.13 Authors: K. C. Prince, E. Allaria, C. Callegari, R. Cucini, G. De Ninno, S. Di Mitri, B. Diviacco, E. Ferrari, P. Finetti, D. Gauthier, L. Giannessi, N. Mahne, G. Penco, O. Plekan, L. Raimondi, P. Rebernik, E. Roussel, C. Svetina, M. Trovò, M. Zangrando, M. Negro, P. Carpeggiani, M. Reduzzi, G. Sansone, A. N. Grum-Grzhimailo, E. V. Gryzlova, S. I. Strakhova, K. Bartschat, N. Douguet, J. Venzke, D. Iablonskyi, Y. Kumagai, T. Takanashi, K. Ueda, A. Fischer, M. Coreno, F. Stienkemeier, Y. Ovcharenko, T. Mazza & M. Meyer Extreme ultraviolet and X-ray free-electron lasers (FELs) produce short-wavelength pulses with high intensity, ultrashort duration, well-defined polarization and transverse coherence, and have been utilized for many experiments previously possible only at long wavelengths: multiphoton ionization, pumping an atomic laser and four-wave mixing spectroscopy. However one important optical technique, coherent control, has not yet been demonstrated, because self-amplified spontaneous emission FELs have limited longitudinal coherence. Single-colour pulses from the FERMI seeded FEL are longitudinally coherent, and two-colour emission is predicted to be coherent. Here, we demonstrate the phase correlation of two colours, and manipulate it to control an experiment. Light of wavelengths 63.0 and 31.5 nm ionized neon, and we controlled the asymmetry of the photoelectron angular distribution by adjusting the phase, with a temporal resolution of 3 as. This opens the door to new short-wavelength coherent control experiments with ultrahigh time resolution and chemical sensitivity.
    Print ISSN: 1749-4885
    Electronic ISSN: 1749-4893
    Topics: Physics
    Published by Nature Publishing Group (NPG)
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  • 6
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    Yap Localization during Mechanosensing Requires Filamentous Actin [Cell Biology] (2016)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
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    Publication Date: 2016-03-19
    Description: Cell-cell contact inhibition and the mechanical environment of cells have both been shown to regulate YAP nuclear localization to modulate cell proliferation. Changes in cellular contractility by genetic, pharmacological, and matrix stiffness perturbations regulate YAP nuclear localization. However, because contractility and F-actin organization are interconnected cytoskeletal properties, it remains unclear which of these distinctly regulates YAP localization. Here we show that in the absence of cell-cell contact, actomyosin contractility suppresses YAP phosphorylation at Ser112, however, neither loss of contractility nor increase in YAP phosphorylation is sufficient for its nuclear exclusion. We find that actin cytoskeletal integrity is essential for YAP nuclear localization, and can override phosphoregulation or contractility-mediated regulation of YAP nuclear localization. This actin-mediated regulation is conserved during mechanotransduction, as substrate compliance increased YAP phosphorylation and reduced cytoskeletal integrity leading to nuclear exclusion of both YAP and Ser(P)112-YAP. These data provide evidence for two actin-mediated pathways for YAP regulation; one in which actomyosin contractility regulates YAP phosphorylation, and a second that involves cytoskeletal integrity-mediated regulation of YAP nuclear localization independent of contractility. We suggest that in non-contact inhibited cells, this latter mechanism may be important in low stiffness regimes, such as may be encountered in physiological environments.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 7
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    Species-specific Activation of Human TRPA1 by Protons [Neurobiology] (2013)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
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    Publication Date: 2013-07-13
    Description: The surveillance of acid-base homeostasis is concerted by diverse mechanisms, including an activation of sensory afferents. Proton-evoked activation of rodent sensory neurons is mainly mediated by the capsaicin receptor TRPV1 and acid-sensing ion channels. In this study, we demonstrate that extracellular acidosis activates and sensitizes the human irritant receptor TRPA1 (hTRPA1). Proton-evoked membrane currents and calcium influx through hTRPA1 occurred at physiological acidic pH values, were concentration-dependent, and were blocked by the selective TRPA1 antagonist HC030031. Both rodent and rhesus monkey TRPA1 failed to respond to extracellular acidosis, and protons even inhibited rodent TRPA1. Accordingly, mouse dorsal root ganglion neurons lacking TRPV1 only responded to protons when hTRPA1 was expressed heterologously. This species-specific activation of hTRPA1 by protons was reversed in both mouse and rhesus monkey TRPA1 by exchange of distinct residues within transmembrane domains 5 and 6. Furthermore, protons seem to interact with an extracellular interaction site to gate TRPA1 and not via a modification of intracellular N-terminal cysteines known as important interaction sites for electrophilic TRPA1 agonists. Our data suggest that hTRPA1 acts as a sensor for extracellular acidosis in human sensory neurons and should thus be taken into account as a yet unrecognized transduction molecule for proton-evoked pain and inflammation. The species specificity of this property is unique among known endogenous TRPA1 agonists, possibly indicating that evolutionary pressure enforced TRPA1 to inherit the role as an acid sensor in human sensory neurons.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 8
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    Treatment of poor graft function after allogeneic hematopoietic cell transplantation with a booster of CD34-selected cells infused without conditioning (2014)
    Nature Publishing Group (NPG)
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    Publication Date: 2014-05-08
    Description: Treatment of poor graft function after allogeneic hematopoietic cell transplantation with a booster of CD34-selected cells infused without conditioning Bone Marrow Transplantation 49, 720 (May 2014). doi:10.1038/bmt.2014.5 Authors: B Askaa, A Fischer-Nielsen, L Vindeløv, E K Haastrup & H Sengeløv
    Print ISSN: 0268-3369
    Electronic ISSN: 1476-5365
    Topics: Medicine
    Published by Nature Publishing Group (NPG)
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  • 9
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    Characterization of the CagA-CagF Interaction [Molecular Biophysics] (2013)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
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    Publication Date: 2013-11-16
    Description: CagA is a virulence factor that Helicobacter pylori inject into gastric epithelial cells through a type IV secretion system where it can cause gastric adenocarcinoma. Translocation is dependent on the presence of secretion signals found in both the N- and C-terminal domains of CagA and an interaction with the accessory protein CagF. However, the molecular basis of this essential protein-protein interaction is not fully understood. Herein we report, using isothermal titration calorimetry, that CagA forms a 1:1 complex with a monomer of CagF with nm affinity. Peptide arrays and isothermal titration calorimetry both show that CagF binds to all five domains of CagA, each with μm affinity. More specifically, a coiled coil domain and a C-terminal helix within CagF contacts domains II-III and domain IV of CagA, respectively. In vivo complementation assays of H. pylori with a double mutant, L36A/I39A, in the coiled coil region of CagF showed a severe weakening of the CagA-CagF interaction to such an extent that it was nearly undetectable. However, it had no apparent effect on CagA translocation. Deletion of the C-terminal helix of CagF also weakened the interaction with CagA but likewise had no effect on translocation. These results indicate that the CagA-CagF interface is distributed broadly across the molecular surfaces of these two proteins to provide maximal protection of the highly labile effector protein CagA.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 10
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    Metaphosphate Stabilization in the Myosin ATPase [Enzymology] (2013)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
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    Publication Date: 2013-12-07
    Description: It has been proposed recently that ATP hydrolysis in ATPase enzymes proceeds via an initial intermediate in which the dissociated γ-phosphate of ATP is bound in the protein as a metaphosphate (PγO3−). A combined quantum/classical analysis of this dissociated nucleotide state inside myosin provides a quantitative understanding of how the enzyme stabilizes this unusual metaphosphate. Indeed, in vacuum, the energy of the ADP3−·PγO3−·Mg2+ complex is much higher than that of the undissociated ATP4−. The protein brings it to a surprisingly low value. Energy decomposition reveals how much each interaction in the protein stabilizes the metaphosphate state; backbone peptides of the P-loop contribute 50% of the stabilization energy, and the side chain of Lys-185+ contributes 25%. This can be explained by the fact that these groups make strong favorable interactions with the α- and β-phosphates, thus favoring the charge distribution of the metaphosphate state over that of the ATP state. Further stabilization (16%) is achieved by a hydrogen bond between the backbone C=O of Ser-237 (on loop Switch-1) and a water molecule perfectly positioned to attack the PγO3− in the subsequent hydrolysis step. The planar and singly negative PγO3− is a much better target for the subsequent nucleophilic attack by a negatively charged OH− than the tetrahedral and doubly negative PγO42− group of ATP. Therefore, we argue that the present mechanism of metaphosphate stabilization is common to the large family of nucleotide-hydrolyzing enzymes. Methodologically, this work presents a computational approach that allows us to obtain a truly quantitative conception of enzymatic strategy.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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