Description: Introduction As the accurate diagnosis and treatment of gestational diabetes mellitus (GDM) is of increasing importance; new diagnostic approaches for the assessment of GDM in early pregnancy were recently suggested. We evaluate the diagnostic power of an ‘early’ oral glucose tolerance test (OGTT) 75 g and glycosylated fibronectin (glyFn) for GDM screening in a normal cohort. Methods and analysis In a prospective cohort study, 748 singleton pregnancies are recruited in 6 centres in Switzerland, Austria and Germany. Women are screened for pre-existing diabetes mellitus and GDM by an ‘early’ OGTT 75 g and/or the new biomarker, glyFn, at 12–15 weeks of gestation. Different screening strategies are compared to evaluate the impact on detection of GDM by an OGTT 75 g at 24–28 weeks of gestation as recommended by the International Association of Diabetes and Pregnancy Study Groups (IADPSG). A new screening algorithm is created by using multivariable risk estimation based on ‘early’ OGTT 75 g and/or glyFn results, incorporating maternal risk factors. Recruitment began in May 2014. Ethics and dissemination This study received ethical approval from the ethics committees in Basel, Zurich, Vienna, Salzburg and Freiburg. It was registered under http://www.ClinicalTrials.gov (NCT02035059) on 12 January 2014. Data will be presented at international conferences and published in peer-reviewed journals. Trial registration number NCT02035059.

Description: The structure of the inclusion compound (FeCp2)4@COF-102 is dominated by [small pi]-[small pi] interactions, with a unique arrangement of FeCp2 molecules which replicates the host structure. Suresh Babu Kalidindi, Kirill Yusenko, Roland A. Fischer ( from Chem. Commun.) Suresh Babu Kalidindi, Chem. Commun., 2011, DOI: 10.1039/C1CC11450F To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: Thin porous films of [Cu3(btc)2]n metal organic framework were deposited in a stepwise manner on surfaces of flexible organic polymers. The thickness of deposited film can be precisely controlled. The deposition of the first cycles was monitored by UV-vis spectroscopy. Mikhail Meilikhov, Kirill Yusenko, Eckhardt Schollmeyer, Christian Mayer, Hans-Jurgen Buschmann, Roland A. Fischer ( from Dalton Trans.) Mikhail Meilikhov, Dalton Trans., 2011, DOI: 10.1039/C0DT01820A To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: Mingyan Ma, Annika Gross, Denise Zacher, Antonio Pinto, Heshmat Noei, Yuemin Wang, Roland A. Fischer, Nils Metzler-Nolte (Communication from CrystEngComm) Mingyan Ma, CrystEngComm, 2011, DOI: 10.1039/c0ce00416b To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: Confocal laser scanning microscopy was used to determine the distribution of fluorescent dyes adsorbed within the bulk or bonded to the external surface of MOF crystals. Mingyan Ma, Annika Gross, Denise Zacher, Antonio Pinto, Heshmat Noei, Yuemin Wang, Roland A. Fischer, Nils Metzler-Nolte ( from CrystEngComm) Mingyan Ma, CrystEngComm, 2011, DOI: 10.1039/C0CE00416B To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: The successful heteroepitaxial growth of perfectly oriented hybrid MOF thin films was achieved by employing liquid-phase epitaxy (LPE). [Zn2(ndc)2(dabco)]n was grown on [Cu2(ndc)2(dabco)]n, thus demonstrating that the MOF-on-MOF deposition scheme developed for powdered MOF materials can also be applied in connection with LPE. O. Shekhah, K. Hirai, H. Wang, H. Uehara, M. Kondo, S. Diring, D. Zacher, R. A. Fischer, O. Sakata, S. Kitagawa, S. Furukawa, C. Woll ( from Dalton Trans.) O. Shekhah, Dalton Trans., 2011, DOI: 10.1039/C0DT01818J To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: O. Shekhah, K. Hirai, H. Wang, H. Uehara, M. Kondo, S. Diring, D. Zacher, R. A. Fischer, O. Sakata, S. Kitagawa, S. Furukawa, C. Woll (Paper from Dalton Trans.) O. Shekhah, Dalton Trans., 2011, DOI: 10.1039/c0dt01818j To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: Strongly oriented Co3O4 thin films were grown on MgO(100) and MgAl2O4(100) by plasma CVD. XPS, SIMS, FE-SEM and XRD2 analyses evidenced that a tailored structural/morphological evolution could be obtained as a function of the process parameters. Davide Barreca, Anjana Devi, Roland A. Fischer, Daniela Bekermann, Alberto Gasparotto, Marco Gavagnin, Chiara Maccato, Eugenio Tondello, Elza Bontempi, Laura E. Depero, Cinzia Sada ( from CrystEngComm) Davide Barreca, CrystEngComm, 2011, DOI: 10.1039/C1CE05280B To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: O. Shekhah, J. Liu, R. A. Fischer, Ch. Woll (Critical Review from Chem. Soc. Rev.) O. Shekhah, Chem. Soc. Rev., 2011, DOI: 10.1039/c0cs00147c To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

Description: Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study, we investigated the potential of targeting the catalytic class I A PI3K isoforms in small cell lung cancer (SCLC), which is the most aggressive of all lung cancer types. Experimental Design: The expression of PI3K isoforms in patient specimens was analyzed. The effects on SCLC cell survival and downstream signaling were determined following PI3K isoform inhibition by selective inhibitors or downregulation by siRNA. Results: Overexpression of the PI3K isoforms p110-α and p110-β and the antiapoptotic protein Bcl-2 was shown by immunohistochemistry in primary SCLC tissue samples. Targeting the PI3K p110-α with RNA interference or selective pharmacologic inhibitors resulted in strongly affected cell proliferation of SCLC cells in vitro and in vivo , whereas targeting p110-β was less effective. Inhibition of p110-α also resulted in increased apoptosis and autophagy, which was accompanied by decreased phosphorylation of Akt and components of the mTOR pathway, such as the ribosomal S6 protein, and the eukaryotic translation initiation factor 4E-binding protein 1. A DNA microarray analysis revealed that p110-α inhibition profoundly affected the balance of pro- and antiapoptotic Bcl-2 family proteins. Finally, p110-α inhibition led to impaired SCLC tumor formation and vascularization in vivo . Conclusion: Together our data show the key involvement of the PI3K isoform p110-α in the regulation of multiple tumor-promoting processes in SCLC. Clin Cancer Res; 19(1); 96–105. ©2012 AACR .