Publication Date:
2014-12-17
Description:
Publication date: Available online 15 December 2014 Source: Magnetic Resonance Imaging Author(s): Maciej Piskunowicz , Lucie Hofmann , Emilie Zuercher , Isabelle Bassi , Bastien Milani , Matthias Stuber , Krzysztof Narkiewicz , Bruno Vogt , Michel Burnier , Menno Pruijm Objectives To assess inter-observer variability of renal blood oxygenation level-dependent MRI (BOLD-MRI) using a new method of analysis, called the concentric objects (CO) technique, in comparison with the classical ROI (region of interest)-based technique. Methods MR imaging (3 T) was performed before and after furosemide in 10 chronic kidney disease (CKD) patients (mean eGFR 43 ± 24 ml/min/1.73 m 2 ) and 10 healthy volunteers (eGFR 101 ± 28 ml/min1.73 m 2 ), and R2* maps determined on four coronal slices. In the CO-technique, R2* values were based on a semi-automatic procedure that divided each kidney in six equal layers, whereas in the ROI-technique, all circles (ROIs) were placed manually in the cortex and medulla. The mean R2*values as assessed by two independent investigators were compared. Results With the CO-technique, inter-observer variability was 0.7-1.9% across all layers in non-CKD, versus 1.6-3.8% in CKD. With the ROI-technique, median variability for cortical and medullary R2* values was 3.6 and 6.8% in non-CKD, versus 4.7 and 12.5% in CKD; similar results were observed after furosemide. Conclusion The CO-technique offers a new, investigator-independent, highly reproducible alternative to the ROI-based technique to estimate renal tissue oxygenation in CKD.
Print ISSN:
0730-725X
Electronic ISSN:
1873-5894
Topics:
Medicine
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