Abstract
Multiple sclerosis (MS) patients frequently develop some form of ocular motor dysfunction during the disease. In previous studies, ocular motor abnormalities were found to correlate with clinical disability and with impaired cognitive performance. The objective of this study was to assess the pursuit ocular movement (POM) frequency in relapsing–remitting (RR) and secondary progressive (SP) MS patients by using a vision-based non-intrusive eye tracker. POM frequency was significantly lower (p < 0.001) in MS patients compared to normal controls. No differences between RR and SP-MS patients and no correlation between POM and expanded disability status scale (EDSS) score were found. This exploratory study suggests that our vision-based system is a new simple non-intrusive method showing impairment of POM values in MS patients, even in the absence of association with clinical disability (EDSS). Future works on larger cohorts of MS patients might validate this eye tracking in MS clinical practice.
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References
Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907–911
Compston C, Coles A (2008) Multiple sclerosis. Lancet 372:1502–1517
Frohman EM, Frohman TC, Zee DS, McColl R, Galetta S (2005) The neuro-ophthalmology of multiple sclerosis. Lancet Neurol 4:111–121
Niestroy A, Rucker JC, Leigh RJ (2007) Neuro-ophthalmologic aspects of multiple sclerosis: using eye movements as a clinical and experimental tool. Clin Ophthalmol 1:267–272
De Seze J, Vukusic S, Viallet-Marcel M et al (2006) Unusual ocular motor findings in multiple sclerosis. J Neurol Sci 243:91–95
Rufa A, Cerase A, De Santi L et al (2008) Impairment of vertical saccades from an acute pontine lesion in multiple sclerosis. J Neuroophthalmol 28:305–307
Halmagyi GM, Colebatch JG, Curthoys IS (1994) New tests of vestibular function. Baillieres Clin Neurol 3:485–500
Van Dongen MM, Bertelsmann FW, Polman CH (1991) Sensitivity of eye movement registration and visual evoked potentials in evaluation of therapy in patients with multiple sclerosis. J Neurol Sci 102:25–31
Flipse JP, Straathof CS, Van der Steen J, Van Leeuwen AF, Van Doorn PA, Van der Meché FG, Collewijn H (1997) Binocular saccadic eye movements in multiple sclerosis. J Neurol Sci 148:53–65
Serra A, Derwenskus J, Downey DL, Leigh RJ (2003) Role of eye movement examination and subjective visual vertical in clinical evaluation of multiple sclerosis. J Neurol 250:569–575
Kurtzke JK (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452
Fielding J, Kilpatrick T, Millist L, White O (2009) Control of visually guided saccades in multiple sclerosis: disruption to higher-order processes. Neuropsychologia 47:1647–1653
Hutton SB (2008) Cognitive control of saccadic eye movements. Brain Cogn 68:327–340
Fielding J, Kilpatrick T, Millist L, White O (2009) Antisaccade performance in patients with multiple sclerosis. Cortex 45:900–903
Marino S, Sessa E, Di Lorenzo G et al (2007) Quantitative analysis of pursuit ocular movements in Parkinson’s disease by using a video-based eye tracking system. Eur Neurol 58:193–197
Marino S, Lanzafame P, Sessa E, Bramanti A, Bramanti P (2009) The effect of l-dopa administration on pursuit ocular movements in suspected Parkinson’s disease. Neurol Sci 19:1–5
McDonald WI, Compston A, Edan G et al (2001) Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 50:121–127
Daumer M, Neuhaus A, Morrissey S, Hintzen R, Ebers GC (2009) MRI as an outcome in multiple sclerosis clinical trials. Neurology 72:705–711
Derwenskus J, Rucker JC, Serra A et al (2005) Abnormal eye movements predict disability in MS: two-year follow-up. Ann NY Acad Sci 1039:521–523
Fielding J, Kilpatrick T, Millist L, White O (2009) Multiple sclerosis: cognition and saccadic eye movements. J Neurol Sci 277:32–36
Amato MP, Ponziani G, Siracusa G, Sorbi S (2001) Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 58:1602–1606
Sartori E, Edan G (2006) Assessment of cognitive dysfunction in multiple sclerosis. J Neurol Sci 245:169–175
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De Santi, L., Lanzafame, P., Spanò, B. et al. Pursuit ocular movements in multiple sclerosis: a video-based eye-tracking study. Neurol Sci 32, 67–71 (2011). https://doi.org/10.1007/s10072-010-0395-1
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DOI: https://doi.org/10.1007/s10072-010-0395-1