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RETRACTED ARTICLE: Molecular subtypes based on PANoptosis-related genes and tumor microenvironment infiltration characteristics in lower-grade glioma

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This article was retracted on 11 May 2024

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Abstract

The growth of cancer, the effectiveness of treatment, and prognosis are all closely related to PANoptosis (include pyroptosis, apoptosis, and necroptosis). It remains unclear whether PANoptosis genes (PANGs) may contribute to lower-grade glioma (LGG) tumor microenvironment (TME). In this study, we collected 1203 LGG samples from three public databases and reported that PANoptosis involves TME interaction and prognosis. Firstly, we provided a comprehensive review of the pan-cancer landscape of PANGs in terms of expression characteristics, prognostic value, mutational profile, and pathway regulation. Then, we identified two distinct PANclusters, each with its own molecular, clinical, and immunological profile. We then developed a scoring system for LGG patients called PANscore. As well as investigating immune characteristics, tumor mutational characteristics, and drug sensitivity, we examined the differences between groups with high PANscores and those with low PANscores. Based on this PANscore and clinicopathological variables, an instant nomogram for predicting clinical survival in LGG patients was developed. Our thorough examination of PANGs in LGG revealed their probable function in TME, as well as their clinicopathological characteristics and prognosis. These discoveries could deepen our comprehension of PANGs in LGG and provide doctors fresh perspectives on how to forecast prognosis and create more efficient, individualized treatment plans.

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Funding

This work was supported by the Xinjiang Key Laboratory of Neurological Disorder Research (grant number: XJDX1711-2202).

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Authors and Affiliations

  1. Department of Neurosurgery, Neurosurgery Centre, the First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinshi District, Urumqi, Xinjiang, 830054, China

    Aimitaji Abulaiti, Aierpati Maimaiti, Qiang Fu, Shaoshan Li, Yabin Li, Yongxin Wang & Qingjiu Zhou

  2. Xinjiang Medical University, Urumqi, Xinjiang, 830054, China

    Nadire Yiming

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  1. Aimitaji Abulaiti
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  2. Aierpati Maimaiti
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  3. Nadire Yiming
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  6. Yabin Li
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  7. Yongxin Wang
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Contributions

AA, AM: the study’s design, data analysis, and article writing were all completed. NY, QF, SL, YL: checked the text and assisted with data analysis and collation. YW, QZ: reviewed and revised the manuscript. The article’s submission was reviewed and approved by all authors.

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Correspondence to Yongxin Wang or Qingjiu Zhou.

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This article has been retracted. Please see the retraction notice for more detail:https://doi.org/10.1007/s10142-024-01374-3

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Abulaiti, A., Maimaiti, A., Yiming, N. et al. RETRACTED ARTICLE: Molecular subtypes based on PANoptosis-related genes and tumor microenvironment infiltration characteristics in lower-grade glioma. Funct Integr Genomics 23, 84 (2023). https://doi.org/10.1007/s10142-023-01003-5

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