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99mTc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation

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Radiochemistry Aims and scope

Abstract

Oxiracetam was labeled with 99mTc using sodium dithionite (Na2S2O4) as a reducing agent. The influence exerted on the labeling yield by the amounts of the reducing agent and substrate, pH, temperature, and reaction time was studied to optimize the labeling process. Biodistribution studies show that the 99mTcoxiracetam complex is suitable as a highly selective tracer for brain imaging.

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Authors and Affiliations

  1. Labeled Compounds Department, Hot Laboratories Center, Atomic Energy Authority, P.O. Box 13759, Cairo, Egypt

    M. H. Sanad & Kh. M. Sallam

  2. Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt

    D. H. Salama

Authors
  1. M. H. Sanad
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  2. Kh. M. Sallam
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  3. D. H. Salama
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Corresponding author

Correspondence to M. H. Sanad.

Additional information

Published in Russian in Radiokhimiya, 2018, Vol. 60, No. 1, pp. 55–59.

The text was submitted by the authors in English.

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Sanad, M.H., Sallam, K.M. & Salama, D.H. 99mTc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation. Radiochemistry 60, 58–63 (2018). https://doi.org/10.1134/S1066362218010101

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  • DOI: https://doi.org/10.1134/S1066362218010101

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