Propionic acidaemia is an inheirited metabolic condition caused by a lack of a liver enzyme, which leads to accumulation of toxic compounds. In a first-in-human trial, a therapeutic messenger RNA drug (mRNA-3927) led to restored enzyme activity, was well tolerated and showed a promising dose-dependent reduction of potentially life-threatening clinical events.

A two-in-one drug that modulates neural pathways involved in appetite and reward might prove to be more effective and longer lasting than current weight-loss drugs on the market.

A design principle for buildings incorporates components that can control the propagation of failure by isolating parts of the structure as they fail — offering a way to prevent a partial collapse snowballing into complete destruction.

Both parents of oldfield mice care for offspring, whereas in deer mice, mothers usually care for pups. The discovery of a type of adrenal-gland cell that is present in oldfield mice but not in deer mice helps to explain the difference.