GEOMAR - Helmholtz-Zentrum für Ozeanforschung Kiel

Intro -- Contents -- 1: Rise of the Theranostics Empire: A Commentary on Dr. Baum's Achievements -- 1.1 The Beginning -- 1.2 The Impedance -- 1.3 The Fertilization -- 1.4 Hard Yards -- 1.5 Expansion of the Empire -- 1.6 New Capital -- 2: Review of F-18 FDG PET/CT in Evaluating Response to Immunotherapy Treatment -- 2.1 Introduction -- 2.2 Patterns of Response -- 2.2.1 Pseudoprogression -- 2.2.2 Hyperprogression -- 2.2.3 Durable Response -- 2.3 Mechanism -- 2.4 18FPET CT and irAE -- 2.4.1 Therapy-Related Inflammation and Inverse Relation Liver SUV/Spleen SUV [18] -- 2.5 Conclusion -- References -- 3: Surgery in Combination with Peptide Receptor Radionuclide Therapy: A Novel Approach for the Treatment of Advanced Neuroendocrine Tumours -- 3.1 Introduction -- 3.2 Molecular Imaging of Neuroendocrine Neoplasms -- 3.3 Surgical Treatment -- 3.4 Surgery in Combination with Peptide Receptor Radionuclide Therapy -- 3.5 Conclusions -- References -- 4: From Concept to Clinic and Commercialization: Cowboys Wanted -- 4.1 Professor Richard Baum -- 4.2 The Great Bexxar® Disaster -- 4.3 "Us Versus Them" -- 4.4 Intellectual Property: Who Cares? -- 4.5 Imaging Is Not an Easy Business -- 4.6 Entrepreneurs Beware -- 4.7 Build It and They Will Come -- 4.8 A Fragile Supply Chain -- 4.9 Future Frontiers -- 4.10 Concluding Remarks -- References -- 5: From Radiochemistry of the Lanthanides to 225Ac and the Interference with Richard Baum -- 5.1 Personal Introduction -- 5.2 Situation of Nuclear Medicine in the 60-th -- 5.3 How to Make Sort-lived Nuclides Far from Beta Stability -- 5.4 Optimized Extraction Chromatography -- 5.5 Separations Based on Szilard-Chalmers Effect -- 5.6 High-temperature Release Studies of Radio-lanthanides from Refractory Metals -- 5.7 ISOLDE and the On-line Production Lanthanide Nuclides.