The 2023 MDPI Annual Report has
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Article
The Ribbon Elements of the Quantum Double of Generalized Taft–Hopf Algebra
by Hua Sun, Yuyan Zhang, Ziliang Jiang, Mingyu Huang and Jiawei Hu
Mathematics 2024, 12(12), 1802; https://doi.org/10.3390/math12121802 (registering DOI) - 10 Jun 2024
Abstract
Let s, t be two positive integers and k be an algebraically closed field with char (k)st. We show that the Drinfeld double D(st,t*cop) of [...] Read more.
Let s, t be two positive integers and k be an algebraically closed field with char (k)st. We show that the Drinfeld double D(st,t*cop) of generalized Taft–Hopf algebra st,t*cop has ribbon elements if and only if t is odd. Moreover, if s is even and t is odd, then D(st,t*cop) has two ribbon elements, and if both s and t are odd, then D(st,t*cop) has only one ribbon element. Finally, we compute explicitly all ribbon elements of D(st,t*cop). Full article
(This article belongs to the Special Issue Advanced Research in Pure and Applied Algebra)
21 pages, 9870 KiB  
Review
Review on Power Cycling Reliability of SiC Power Device
by Xu Gao, Qiang Jia, Yishu Wang, Hongqiang Zhang, Limin Ma, Guisheng Zou and Fu Guo
Electron. Mater. 2024, 5(2), 80-100; https://doi.org/10.3390/electronicmat5020007 (registering DOI) - 10 Jun 2024
Abstract
The rising demand for increased integration and higher power outputs poses a hidden risk to the long-term reliable operation of third-generation semiconductors. Thus, the power cycling test (PCT) is widely regarded as the utmost critical test for assessing the packaging reliability of power [...] Read more.
The rising demand for increased integration and higher power outputs poses a hidden risk to the long-term reliable operation of third-generation semiconductors. Thus, the power cycling test (PCT) is widely regarded as the utmost critical test for assessing the packaging reliability of power devices. In this work, low-thermal-resistance packaging design structures of SiC devices are introduced, encompassing planar packaging with dual heat dissipation, press-pack packaging, three-dimensional (3D) packaging, and hybrid packaging. PCT methods and their control strategies are summarized and discussed. Direct-current PCT is the focus of this review. The failure mechanisms of SiC devices under PCT are pointed out. The electrical and temperature-sensitive parameters adopted to monitor the aging of SiC devices are organized. The existing international standards for PCT are evaluated. Due to the lack of authoritative statements for SiC devices, it is difficult to achieve comparison research results without consistent preconditions. Furthermore, the lifetimes of the various packaging designs of the tested SiC devices under PCTs are statistically analyzed. Additionally, problems related to parameter monitoring and test equipment are also summarized. This review explores the broader landscape by delving into the current challenges and main trends in PCTs for SiC devices. Full article
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13 pages, 1328 KiB  
Review
Role of Secretory Mucins in the Occurrence and Development of Cholelithiasis
by Zeying Zhao, Ye Yang, Shuodong Wu and Dianbo Yao
Biomolecules 2024, 14(6), 676; https://doi.org/10.3390/biom14060676 (registering DOI) - 10 Jun 2024
Abstract
Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, [...] Read more.
Cholelithiasis is a common biliary tract disease. However, the exact mechanism underlying gallstone formation remains unclear. Mucin plays a vital role in the nuclear formation and growth of cholesterol and pigment stones. Excessive mucin secretion can result in cholestasis and decreased gallbladder activity, further facilitating stone formation and growth. Moreover, gallstones may result in inflammation and the secretion of inflammatory factors, which can further increase mucin expression and secretion to promote the growth of gallstones. This review systematically summarises and analyses the role of mucins in gallstone occurrence and development and its related mechanisms to explore new ideas for interventions in stone formation or recurrence. Full article
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23 pages, 11883 KiB  
Article
Improved Identification of Forest Types in the Loess Plateau Using Multi-Source Remote Sensing Data, Transfer Learning, and Neural Residual Networks
by Mei Zhang, Daihao Yin, Zhen Li and Zhong Zhao
Remote Sens. 2024, 16(12), 2096; https://doi.org/10.3390/rs16122096 (registering DOI) - 10 Jun 2024
Abstract
This study aims to establish a deep learning-based classification framework to efficiently and rapidly distinguish between coniferous and broadleaf forests across the Loess Plateau. By integrating the deep residual neural network (ResNet) architecture with transfer learning techniques and multispectral data from unmanned aerial [...] Read more.
This study aims to establish a deep learning-based classification framework to efficiently and rapidly distinguish between coniferous and broadleaf forests across the Loess Plateau. By integrating the deep residual neural network (ResNet) architecture with transfer learning techniques and multispectral data from unmanned aerial vehicles (UAVs) and Landsat remote sensing data, the effectiveness of the framework was validated through well-designed experiments. The study began by selecting optimal spectral band combinations, using the random forest algorithm. Pre-trained models were then constructed, and model performance was optimized with different training strategies, considering factors such as image size, sample quantity, and model depth. The results indicated substantial improvements in the model’s classification accuracy and efficiency for reasonable image dimensions and sample sizes, especially for an image size of 3 × 3 pixels and 2000 samples. In addition, the application of transfer learning and model fine-tuning strategies greatly enhanced the adaptability and universality of the model in different classification scenarios. The fine-tuned model achieved remarkable performance improvements in forest-type classification tasks, increasing classification accuracy from 85% to 93% in Zhengning, from 89% to 96% in Yongshou, and from 86% to 94% in Baishui, as well as exceeding 90% in all counties. These results not only confirm the effectiveness of the proposed framework, but also emphasize the roles of image size, sample quantity, and model depth in improving the generalization ability and classification accuracy of the model. In conclusion, this research has developed a technological framework for effective forest landscape recognition, using a combination of multispectral data from UAVs and Landsat satellites. This combination proved to be more effective in identifying forest types than was using Landsat data alone, demonstrating the enhanced capability and accuracy gained by integrating UAV technology. This research provides valuable scientific guidance and tools for policymakers and practitioners in forest management and sustainable development. Full article
(This article belongs to the Section Remote Sensing and Geo-Spatial Science)
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20 pages, 7213 KiB  
Article
Slow Well-Being Gardening: Creating a Sensor Network for Radiation Therapy Patients via Horticultural Therapeutic Activity
by Teng-Wen Chang, Shih-Ting Tsai, Hsin-Yi Huang, Yi-Sin Wu, Ching-Chih Chang and Sambit Datta
Sensors 2024, 24(12), 3771; https://doi.org/10.3390/s24123771 (registering DOI) - 10 Jun 2024
Abstract
Well-being can reflect people’s psychological conditions and be used alongside physiological parameters to evaluate patients’ physical and mental health. The modern medical environment increasingly incorporates digital carriers, human–computer interaction devices, sensible spaces, and the execution of suitable algorithms. Slow design in healthy human–computer [...] Read more.
Well-being can reflect people’s psychological conditions and be used alongside physiological parameters to evaluate patients’ physical and mental health. The modern medical environment increasingly incorporates digital carriers, human–computer interaction devices, sensible spaces, and the execution of suitable algorithms. Slow design in healthy human–computer interaction is often used to reflect people’s dependence on or support from behaviors or objects, promoting the stability of behaviors as well as meaningful and positive changes. Therefore, in this study, we propose a slow sensing model, develop a Slow Well-Being Gardening system, and use it to evaluate behavioral data from radiation therapy patients during treatment sessions and horticultural therapy. This study is based on SENS and slow design, setting the hospital lounge as a sensible space and establishing a sensor system. After a 10-day inspection, the process was evaluated and verified. Ultimately, data from facial detection (smile) and HRV showed that the patients in the experimental group experienced a significant improvement in their well-being, feeling better than those in the control group who maintained the most common state in normal treatment. Therefore, it can be inferred that the Slow Well-Being Gardening model is indeed valid and can be further developed. Full article
(This article belongs to the Section Sensor Networks)
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Article
A Study of the Internal Deformation Fields and the Related Microstructure Evolution during Thermal Fatigue Tests of a Single-Crystal Ni-Base Superalloy
by Cui Zong, Sujie Liu, Guangcai Ma, Yi Guo and Zhaohui Huang
Materials 2024, 17(12), 2821; https://doi.org/10.3390/ma17122821 (registering DOI) - 10 Jun 2024
Abstract
Ni-base superalloys operate in harsh service conditions where cyclic heating and cooling introduce deformation fields that need to be investigated in detail. We used the high-angular-resolution electron backscatter diffraction method to study the evolution of internal stress fields and dislocation density distributions in [...] Read more.
Ni-base superalloys operate in harsh service conditions where cyclic heating and cooling introduce deformation fields that need to be investigated in detail. We used the high-angular-resolution electron backscatter diffraction method to study the evolution of internal stress fields and dislocation density distributions in carbides, dendrites, and notch tips. The results indicate that the stress concentrations decay exponentially away from the notch, and this pattern of distribution was modified by the growth of cracks and the emission of dislocations from the crack tip. Crack initiation follows crystallographic traces and is weakly correlated with carbides and dendrites. Thermal cycles introduce local plasticity around carbides, the dendrite boundary, and cracks. The dislocations lead to higher local stored energy than the critical value that is often cited to induce recrystallization. No large-scale onset of recrystallization was detected, possibly due to the mild temperature (800 °C); however, numerous recrystallized grains were detected in carbides after 50 and 80 cycles. The results call for a detailed investigation of the microstructure-related, thermally assisted recrystallization phenomenon and may assist in the microstructure control and cooling channel design of turbine blades. Full article
(This article belongs to the Section Advanced Materials Characterization)
16 pages, 501 KiB  
Article
Improving the Giant-Armadillo Optimization Method
by Glykeria Kyrou, Vasileios Charilogis and Ioannis G. Tsoulos
Analytics 2024, 3(2), 225-240; https://doi.org/10.3390/analytics3020013 (registering DOI) - 10 Jun 2024
Abstract
Global optimization is widely adopted presently in a variety of practical and scientific problems. In this context, a group of widely used techniques are evolutionary techniques. A relatively new evolutionary technique in this direction is that of Giant-Armadillo Optimization, which is based on [...] Read more.
Global optimization is widely adopted presently in a variety of practical and scientific problems. In this context, a group of widely used techniques are evolutionary techniques. A relatively new evolutionary technique in this direction is that of Giant-Armadillo Optimization, which is based on the hunting strategy of giant armadillos. In this paper, modifications to this technique are proposed, such as the periodic application of a local minimization method as well as the use of modern termination techniques based on statistical observations. The proposed modifications have been tested on a wide series of test functions available from the relevant literature and compared against other evolutionary methods. Full article
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Systematic Review
Oral-Health-Related Quality of Life in Elderly Edentulous Patients with Full-Arch Rehabilitation Treatments: A Systematic Review
by Tin Thinzar Linn, Angkoon Khaohoen, Khaing Myat Thu and Pimduen Rungsiyakull
J. Clin. Med. 2024, 13(12), 3391; https://doi.org/10.3390/jcm13123391 (registering DOI) - 10 Jun 2024
Abstract
Background: The improvement of oral-health-related quality of life (OHRQoL) with different types of prosthesis for completely edentulous jaws in the elderly population is a critical factor in clinical decision making for these vulnerable patients. This review aims to evaluate the changes in [...] Read more.
Background: The improvement of oral-health-related quality of life (OHRQoL) with different types of prosthesis for completely edentulous jaws in the elderly population is a critical factor in clinical decision making for these vulnerable patients. This review aims to evaluate the changes in OHRQoL after treatment with different types of full-arch prostheses in the elderly edentulous population to determine the prostheses that result in the greatest improvement in OHRQoL. Materials and Methods: Clinical studies of different types of full-arch prostheses that measured the OHRQoL in edentulous patients 60 years or older were searched for in the PubMed, Embase and Scopus electronic databases, with additional hand searching to summarize the outcomes of the selected studies. Result: Among the 302 identified studies, 10 studies were selected. A total of 504 patients wearing 133 complete dentures, 372 implant overdentures and 39 fixed prostheses were assessed among the selected studies. The overall OHIP and GOHAI scores were evaluated at baseline and in the 3rd, 6th, 12th and 18th months of treatment with the respective prostheses. The improved OHRQoL with overall OHIP scores associated with conventional dentures were 9.21–12.5% from the 3rd month to 1 year after treatment, whereas those associated with implant overdentures and full-arch fixed prosthesis were 9–25.26% at 1 year and 18.53–26.79 at the 18th-month follow-up, respectively. The increased overall GOHAI scores were 21.3–25.43% for conventional dentures, 36.82–41.32% for implant overdentures and 39.48–42.83% for full-arch fixed prosthesis from the 3rd month to the 6th-month follow-up. Conclusion: In general, the improvement in OHRQoL after rehabilitation with implant overdentures declined at one year, and that with full-arch fixed prosthesis declined at the 18th-month follow-up; meanwhile, the OHRQoL associated with conventional dentures improved stably up to one year, but the implant-supported prostheses resulted in an obviously greater improvement in the OHRQoL than that obtained with conventional dentures. However, studies with longer follow-up periods are still required to evaluate the long-term clinical effectiveness. Full article
(This article belongs to the Special Issue State of the Art of Oral Health in Japan and Other Aging Countries)
Article
Three-Dimensional-Printed Composite Structures: The Effect of LSCF Slurry Solid Loading, Binder, and Direct-Write Process Parameters
by Man Yang, Santosh Kumar Parupelli, Zhigang Xu and Salil Desai
Materials 2024, 17(12), 2822; https://doi.org/10.3390/ma17122822 (registering DOI) - 10 Jun 2024
Abstract
In this research, a direct-write 3D-printing method was utilized for the fabrication of inter-digitized solid oxide fuel cells (SOFCs) using ceramic materials. The cathode electrode was fabricated using the LSCF (La0.6Sr0.2Fe0.8Co0.2O3-δ) slurry loading [...] Read more.
In this research, a direct-write 3D-printing method was utilized for the fabrication of inter-digitized solid oxide fuel cells (SOFCs) using ceramic materials. The cathode electrode was fabricated using the LSCF (La0.6Sr0.2Fe0.8Co0.2O3-δ) slurry loading and the Polyvinyl butyral (PVB) binder. The rheological parameters of slurries with varying LSCF slurry loading and PVB binder concentration were evaluated to determine their effect on the cathode trace performance in terms of microstructure, size, and resistance. Additionally, the dimensional shrinkage of LSCF lines after sintering was investigated to realize their influence on cathode line width and height. Moreover, the effect of the direct-write process parameters such as pressure, distance between the nozzle and substrate, and speed on the cathode line dimensions and resistance was evaluated. LSCF slurry with 50% solid loading, 12% binder, and 0.2% dispersant concentration was determined to be the optimal value for the fabrication of SOFCs using the direct-write method. The direct-write process parameters, in addition to the binder and LSCF slurry concentration ratios, had a considerable impact on the microstructure of cathode lines. Based on ANOVA findings, pressure and distance had significant effects on the cathode electrode resistance. An increase in the distance between the nozzle and substrate, speed, or extrusion pressure of the direct writing process increased the resistance of the cathode lines. These findings add to the ongoing effort to refine SOFC fabrication techniques, opening the avenues for advanced performance and efficiency of SOFCs in energy applications. Full article
(This article belongs to the Special Issue 3D-Printed Composite Structures: Design, Properties and Application)
22 pages, 753 KiB  
Article
Choice Function-Based Hyper-Heuristics for Causal Discovery under Linear Structural Equation Models
by Yinglong Dang, Xiaoguang Gao and Zidong Wang
Biomimetics 2024, 9(6), 350; https://doi.org/10.3390/biomimetics9060350 (registering DOI) - 10 Jun 2024
Abstract
Causal discovery is central to human cognition, and learning directed acyclic graphs (DAGs) is its foundation. Recently, many nature-inspired meta-heuristic optimization algorithms have been proposed to serve as the basis for DAG learning. However, a single meta-heuristic algorithm requires specific domain knowledge and [...] Read more.
Causal discovery is central to human cognition, and learning directed acyclic graphs (DAGs) is its foundation. Recently, many nature-inspired meta-heuristic optimization algorithms have been proposed to serve as the basis for DAG learning. However, a single meta-heuristic algorithm requires specific domain knowledge and empirical parameter tuning and cannot guarantee good performance in all cases. Hyper-heuristics provide an alternative methodology to meta-heuristics, enabling multiple heuristic algorithms to be combined and optimized to achieve better generalization ability. In this paper, we propose a multi-population choice function hyper-heuristic to discover the causal relationships encoded in a DAG. This algorithm provides a reasonable solution for combining structural priors or possible expert knowledge with swarm intelligence. Under a linear structural equation model (SEM), we first identify the partial v-structures through partial correlation analysis as the structural priors of the next nature-inspired swarm intelligence approach. Then, through partial correlation analysis, we can limit the search space. Experimental results demonstrate the effectiveness of the proposed methods compared to the earlier state-of-the-art methods on six standard networks. Full article
(This article belongs to the Special Issue Nature-Inspired Metaheuristic Optimization Algorithms 2024)
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31 pages, 3770 KiB  
Review
Advance of Microemulsion and Application for Enhanced Oil Recovery
by Kaiqi Leng, Baoshan Guan, Weidong Liu, Chen Jiang, Sunan Cong, Baoliang Peng and Yufan Tao
Nanomaterials 2024, 14(12), 1004; https://doi.org/10.3390/nano14121004 (registering DOI) - 10 Jun 2024
Abstract
With the ongoing advancement in oil exploration, microemulsion, as an innovative oil displacement method, has garnered considerable attention owing to its exceptional physicochemical properties in enhancing crude oil recovery. As such, this study initially delineates the fundamental concepts, classifications, formation mechanisms, advantages, and [...] Read more.
With the ongoing advancement in oil exploration, microemulsion, as an innovative oil displacement method, has garnered considerable attention owing to its exceptional physicochemical properties in enhancing crude oil recovery. As such, this study initially delineates the fundamental concepts, classifications, formation mechanisms, advantages, and preparation methodologies of microemulsions. Subsequently, it introduces the selection criteria for microemulsion components, followed by an elucidation of the characterization methods for microemulsions based on these criteria. Furthermore, it examines the factors influencing the efficacy of microemulsions in enhancing oil recovery through two distinct methods, along with the effects of various formulation microemulsions under laboratory and oilfield conditions. Additionally, it outlines prospects, challenges, and future development trends pertaining to microemulsions. Full article
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10 pages, 1240 KiB  
Article
Accuracy of Estimated Fetal Weight Assessment in Fetuses with Congenital Diaphragmatic Hernia—Is the Hadlock Formula a Reliable Tool?
by Daria Kuchnowska, Albert Stachura, Przemyslaw Kosinski, Maciej Gawlak and Piotr Wegrzyn
J. Clin. Med. 2024, 13(12), 3392; https://doi.org/10.3390/jcm13123392 (registering DOI) - 10 Jun 2024
Abstract
Objectives: Congenital diaphragmatic hernia (CDH) is defined as organ protrusion from the abdominal to the thoracic cavity. The Hadlock formula is the most commonly used tool for calculating estimated fetal weight (EFW). The anatomical nature of CDH usually leads to underestimation of [...] Read more.
Objectives: Congenital diaphragmatic hernia (CDH) is defined as organ protrusion from the abdominal to the thoracic cavity. The Hadlock formula is the most commonly used tool for calculating estimated fetal weight (EFW). The anatomical nature of CDH usually leads to underestimation of the abdominal circumference, resulting in underestimation of fetal weight. Accurate weight estimation is essential before birth for counselling, preparation before surgery and ECMO. The research is made to compare the accuracy of Hadlock’s formula and Faschingbauer’s formula for fetal weight estimation in CDH fetuses population. Methods: In our study, we investigated differences between EFW and actual birthweight in 42 fetuses with CDH as compared to 80 healthy matched controls. EFW was calculated using the Hadlock formula and a recently introduced formula described by Faschingbauer et al., which was tailored for fetuses with CDH. Additionally, both of the formulas were adjusted for the interval between the ultrasound and delivery for both of the groups. Results: The majority of hernias were left-sided (92.8% vs. 7.2%). EFW adjusted for the interval between the ultrasound and delivery had the highest correlation with the actual birthweight in both, study group and controls. We compared the results for both tools and found the Hadlock formula to predict birthweight in CDH children with a 7.8 ± 5.5% error as compared to 7.9 ± 6.5% error for the Faschingbauer’s formula. Conclusions: The Hadlock formula adjusted for the interval between the ultrasound and delivery is a more precise method of calculating EFW in fetuses with CDH. Routine biometry scan using Hadlock’s formula remains reliable for predicting birthweight. Full article
(This article belongs to the Special Issue Clinical Outcomes in Maternal–Fetal Medicine)
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Article
Comparative Study of Bacterial Microbiota Differences in the Rumen and Feces of Xinjiang Brown and Holstein Cattle
by Haibo Lu, Shaokan Chen, Fengjie Li, Guoxing Zhang, Juan Geng, Menghua Zhang, Xixia Huang and Yachun Wang
Animals 2024, 14(12), 1748; https://doi.org/10.3390/ani14121748 (registering DOI) - 10 Jun 2024
Abstract
Xinjiang Brown cattle are a unique and widely distributed breed of dual-purpose cattle in the Xinjiang area of China, whose milk production performance differs from Holstein cattle. It has been known that variations in bacterial species of the gastrointestinal tract influence milk protein, [...] Read more.
Xinjiang Brown cattle are a unique and widely distributed breed of dual-purpose cattle in the Xinjiang area of China, whose milk production performance differs from Holstein cattle. It has been known that variations in bacterial species of the gastrointestinal tract influence milk protein, fat, and lactose synthesis. However, the microbiota differences between Xinjiang Brown and Holstein cattle are less known. This study aims to compare the bacterial community composition of the rumen and feces of these two cattle breeds under the same dietary and management conditions. The 16s rRNA sequencing data and milk production of 18 Xinjiang Brown cows and 20 Holstein cows on the same farm were obtained for analysis. The results confirmed differences in milk production between Xinjiang Brown and Holstein cattle. Microbiota with different relative abundance between these two cattle breeds were identified, and their biological functions might be related to milk synthesis. This study increases the understanding of the differences in microbiota between Xinjiang Brown and Holstein cattle and might provide helpful information for microbiota composition optimization of these dairy cattle. Full article
(This article belongs to the Collection Advances in Cattle Breeding, Genetics and Genomics)
Article
Numerical Solution of the Linear Fractional Delay Differential Equation Using Gauss–Hermite Quadrature
by Salma Aljawi, Sarah Aljohani, Kamran, Asma Ahmed and Nabil Mlaiki
Symmetry 2024, 16(6), 721; https://doi.org/10.3390/sym16060721 (registering DOI) - 10 Jun 2024
Abstract
Fractional order differential equations often possess inherent symmetries that play a crucial role in governing their dynamics in a variety of scientific fields. In this work, we consider numerical solutions for fractional-order linear delay differential equations. The numerical solution is obtained via the [...] Read more.
Fractional order differential equations often possess inherent symmetries that play a crucial role in governing their dynamics in a variety of scientific fields. In this work, we consider numerical solutions for fractional-order linear delay differential equations. The numerical solution is obtained via the Laplace transform technique. The quadrature approximation of the Bromwich integral provides the foundation for several commonly employed strategies for inverting the Laplace transform. The key factor for quadrature approximation is the contour deformation, and numerous contours have been proposed. However, the highly convergent trapezoidal rule has always been the most common quadrature rule. In this work, the Gauss–Hermite quadrature rule is used as a substitute for the trapezoidal rule. Plotting figures of absolute error and comparing results to other methods from the literature illustrate how effectively the suggested approach works. Functional analysis was used to examine the existence of the solution and the Ulam–Hyers (UH) stability of the considered equation. Full article
(This article belongs to the Special Issue Differential/Difference Equations and Its Application: Volume II)
23 pages, 3256 KiB  
Article
Combined Treatment of Uterine Leiomyosarcoma with Gamma Secretase Inhibitor MK-0752 and Chemotherapeutic Agents Decreases Cellular Invasion and Increases Apoptosis
by Yasmin Abedin, Alexander Fife, Cherie-Ann Samuels, Rasheena Wright, Trystn Murphy, Xusheng Zhang, Emily Alpert, Emma Cheung, Qingshi Zhao, Mark H. Einstein and Nataki C. Douglas
Cancers 2024, 16(12), 2184; https://doi.org/10.3390/cancers16122184 (registering DOI) - 10 Jun 2024
Abstract
Due to limited effective therapeutics for uterine leiomyosarcoma (uLMS), the impact of the gamma secretase inhibitor (GSI) MK-0752 with common chemotherapeutics was explored in uLMS. MTT assays were performed on two human uLMS cell lines, SK-UT-1B and SK-LMS-1, using MK-0752, docetaxel, doxorubicin, and [...] Read more.
Due to limited effective therapeutics for uterine leiomyosarcoma (uLMS), the impact of the gamma secretase inhibitor (GSI) MK-0752 with common chemotherapeutics was explored in uLMS. MTT assays were performed on two human uLMS cell lines, SK-UT-1B and SK-LMS-1, using MK-0752, docetaxel, doxorubicin, and gemcitabine, individually and in combination, to determine cell viability after treatment. Synergistic combinations were used in transwell invasion assays, cell cycle flow cytometry, proliferation assays, and RNA sequencing. In SK-UT-1B, MK-0752 was synergistic with doxorubicin and gemcitabine plus docetaxel. In SK-LMS-1, MK-0752 was synergistic with all individual agents and with the combination of gemcitabine plus docetaxel. MK-0752, gemcitabine, and docetaxel decreased invasion in SK-UT-1B 2.1-fold* and in SK-LMS-1 1.7-fold*. In SK-LMS-1, invasion decreased 1.2-fold* after treatment with MK-0752 and docetaxel and 2.2-fold* after treatment with MK-0752 and doxorubicin. Cell cycle analysis demonstrated increases in the apoptotic sub-G1 population with MK-0752 alone in SK-UT-1B (1.4-fold*) and SK-LMS-1 (2.7-fold**), along with increases with all combinations in both cell lines. The combination treatments had limited effects on proliferation, while MK-0752 alone decreased proliferation in SK-LMS-1 (0.63-fold**). Both MK-0752 alone and in combination altered gene expression and KEGG pathways. In conclusion, the combinations of MK-0752 with either doxorubicin, docetaxel, or gemcitabine plus docetaxel are potential novel therapeutic approaches for uLMS. (* p < 0.05, ** p < 0.01). Full article
(This article belongs to the Special Issue Clinical Management and Prognosis of Gynecological Cancer)
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13 pages, 465 KiB  
Article
An Assessment of Existing Sport-Related Concussion Guidelines in Ireland: The Need for a United Approach
by Ayrton Walshe, Ed Daly and Lisa Ryan
J. Funct. Morphol. Kinesiol. 2024, 9(2), 101; https://doi.org/10.3390/jfmk9020101 (registering DOI) - 10 Jun 2024
Abstract
In 2014, an Irish parliament white paper called for greater addressing of sport-related concussions (SRCs) in Ireland, requesting the adoption of the Concussion in Sport Group’s (CISGs) guidelines and greater consistency in SRC return to play (RTP) management. Ten years later, it is [...] Read more.
In 2014, an Irish parliament white paper called for greater addressing of sport-related concussions (SRCs) in Ireland, requesting the adoption of the Concussion in Sport Group’s (CISGs) guidelines and greater consistency in SRC return to play (RTP) management. Ten years later, it is unclear how these requests have been addressed. Recently, the United Kingdom’s government centralised guidelines to one SRC document for all grassroots sports. This study aimed to investigate all publicly available SRC guidance in Irish sports and national governing bodies (NGBs) to determine if centralised guidelines are warranted. Sport Ireland and the Irish Federation of Sports were searched for all recognised NGBs and sports in Ireland. Websites were searched for any information pertaining to SRCs and data were extracted and collated in Microsoft Excel. In total, 15 of 83 sports and/or NGBs included SRC guidance, nine of which provided RTP protocols. Various iterations of the CISGs guidance and tools were implemented. Several sports with a documented SRC risk had no guidelines present. The findings indicate disjointed and outdated guidance across Irish sport. Additionally, there are sports with a documented concussion risk that have no SRC guidance available. This study provides support for centralised guidelines to be adopted in Irish grassroots sports. Full article
(This article belongs to the Section Sports Medicine and Nutrition)
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13 pages, 2108 KiB  
Article
Association between Time to Emergent Surgery and Outcomes in Trauma Patients: A 10-Year Multicenter Study
by Chi-Hsuan Tsai, Meng-Yu Wu, Da-Sen Chien, Po-Chen Lin, Jui-Yuan Chung, Chi-Yuan Liu, I-Shiang Tzeng, Yueh-Tseng Hou, Yu-Long Chen and Giou-Teng Yiang
Medicina 2024, 60(6), 960; https://doi.org/10.3390/medicina60060960 (registering DOI) - 10 Jun 2024
Abstract
Background: Research on the impact of reduced time to emergent surgery in trauma patients has yielded inconsistent results. Therefore, this study investigated the relationship between waiting emergent surgery time (WEST) and outcomes in trauma patients. Methods: This retrospective, multicenter study used [...] Read more.
Background: Research on the impact of reduced time to emergent surgery in trauma patients has yielded inconsistent results. Therefore, this study investigated the relationship between waiting emergent surgery time (WEST) and outcomes in trauma patients. Methods: This retrospective, multicenter study used data from the Tzu Chi Hospital trauma database. The primary clinical outcomes were in-hospital mortality, intensive care unit (ICU) admission, and prolonged hospital length of stay (LOS) of ≥30 days. Results: A total of 15,164 patients were analyzed. The median WEST was 444 min, with an interquartile range (IQR) of 248–848 min for all patients. Patients who died in the hospital had a shorter median WEST than did those who survived (240 vs. 446 min, p < 0.001). Among the trauma patients with a WEST of <2 h, the median time was 79 min (IQR = 50–100 min). No significant difference in WEST was observed between the survival and mortality groups for patients with a WEST of <120 min (median WEST: 85 vs. 78 min, p < 0.001). Multivariable logistic regression analysis revealed that WEST was not associated with an increased risk of in-hospital mortality (adjusted odds ratio [aOR] = 1.05, 95% confidence interval [CI] = 0.17–6.35 for 30 min ≤ WEST < 60 min; aOR = 1.12, 95% CI = 0.22–5.70 for 60 min ≤ WEST < 90 min; and aOR = 0.60, 95% CI = 0.13–2.74 for WEST ≥ 90 min). Conclusions: Our findings do not support the “golden hour” concept because no association was identified between the time to definitive care and in-hospital mortality, ICU admission, and prolonged hospital stay of ≥30 days. Full article
(This article belongs to the Special Issue Current Status and Future Directions of Bone Trauma Surgery)
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22 pages, 2910 KiB  
Article
Characterization of Wildland Firefighters’ Exposure to Coarse, Fine, and Ultrafine Particles; Polycyclic Aromatic Hydrocarbons; and Metal(loid)s, and Estimation of Associated Health Risks
by Joana Teixeira, Gabriel Sousa, Rui Azevedo, Agostinho Almeida, Cristina Delerue-Matos, Xianyu Wang, Alice Santos-Silva, Francisca Rodrigues and Marta Oliveira
Toxics 2024, 12(6), 422; https://doi.org/10.3390/toxics12060422 (registering DOI) - 10 Jun 2024
Abstract
Firefighters’ occupational activity causes cancer, and the characterization of exposure during firefighting activities remains limited. This work characterizes, for the first time, firefighters’ exposure to (coarse/fine/ultrafine) particulate matter (PM) bound polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s during prescribed fires, Fire 1 and Fire [...] Read more.
Firefighters’ occupational activity causes cancer, and the characterization of exposure during firefighting activities remains limited. This work characterizes, for the first time, firefighters’ exposure to (coarse/fine/ultrafine) particulate matter (PM) bound polycyclic aromatic hydrocarbons (PAHs) and metal(loid)s during prescribed fires, Fire 1 and Fire 2 (210 min). An impactor collected 14 PM fractions, the PM levels were determined by gravimetry, and the PM-bound PAHs and metal(loid)s were determined by chromatographic and spectroscopic methodologies, respectively. Firefighters were exposed to a total PM level of 1408.3 and 342.5 µg/m3 in Fire 1 and Fire 2, respectively; fine/ultrafine PM represented more than 90% of total PM. Total PM-bound PAHs (3260.2 ng/m3 in Fire 1; 412.1 ng/m3 in Fire 2) and metal(loid)s (660.8 ng/m3 versus 262.2 ng/m3), distributed between fine/ultrafine PM, contained 4.57–24.5% and 11.7–12.6% of (possible/probable) carcinogenic PAHs and metal(loid)s, respectively. Firefighters’ exposure to PM, PAHs, and metal(loid)s were below available occupational limits. The estimated carcinogenic risks associated with the inhalation of PM-bound PAHs (3.78 × 10−9 − 1.74 × 10−6) and metal(loid)s (1.50 × 10−2 − 2.37 × 10−2) were, respectively, below and 150–237 times higher than the acceptable risk level defined by the USEPA during 210 min of firefighting activity and assuming a 40-year career as a firefighter. Additional studies need to (1) explore exposure to (coarse/fine/ultrafine) PM, (2) assess health risks, (3) identify intervention needs, and (4) support regulatory agencies recommending mitigation procedures to reduce the impact of fire effluents on firefighters. Full article
(This article belongs to the Special Issue Firefighters’ Occupational Exposures and Health Risks)
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21 pages, 606 KiB  
Article
Between Wine and Tea: A Discussion Based on Master Taixu’s Use of Dual Imagery
by Xiaoxiao Xu
Religions 2024, 15(6), 718; https://doi.org/10.3390/rel15060718 (registering DOI) - 10 Jun 2024
Abstract
The imagery of wine and tea is important in classical and modern Chinese poetry, with an intricate relationship between the two especially evident in the work of Taixu 太虛 (1890–1947), a prominent poet–monk in 20th-century China. Taixu’s attitude toward wine—a drink that is [...] Read more.
The imagery of wine and tea is important in classical and modern Chinese poetry, with an intricate relationship between the two especially evident in the work of Taixu 太虛 (1890–1947), a prominent poet–monk in 20th-century China. Taixu’s attitude toward wine—a drink that is deeply rooted in Chinese culture—evolves significantly over time, from initial approval to eventual condemnation due to its detrimental effects on both personal health and society. Nevertheless, it continues to feature prominently in his poetry. The same is true of tea, which Taixu often uses to evoke either Buddhist study or his own healthy lifestyle. This article explores this and other complex meanings in Taixu’s poems, such as his association of wine with knights and tea with hermits. It also discusses how he achieves a delicate balance between the two beverages, sometimes employing both types of imagery in a single poem—a literary innovation that helped to establish his reputation as a central figure in modern Chinese poetry. Full article
(This article belongs to the Special Issue The History of Religions in China: The Rise, Fall, and Return)
14 pages, 3232 KiB  
Article
A Fault Diagnosis Method for Analog Circuits Based on Improved TQWT and Inception Model
by Xinjia Yuan, Siting Yang, Wenmin Wang, Yunlong Sheng, Xuye Zhuang and Jiancheng Yin
Symmetry 2024, 16(6), 720; https://doi.org/10.3390/sym16060720 (registering DOI) - 10 Jun 2024
Abstract
A soft fault in an analog circuit is a symptom where the parameter range of a component exists symmetrically to the left and right of its nominal value and exceeds a specific range. The proposed method uses the Grey Wolf Optimization (GWO) optimized [...] Read more.
A soft fault in an analog circuit is a symptom where the parameter range of a component exists symmetrically to the left and right of its nominal value and exceeds a specific range. The proposed method uses the Grey Wolf Optimization (GWO) optimized tunable Q-factor wavelet transform (TQWT) algorithm for feature refinement, the Inception model for feature extraction, and an SVM for fault diagnosis. First, the Q-factor is optimized to make it more compatible with the signal. Second, the signal is decomposed, and a single-branch reconstruction is performed using the TQWT to extract features adequately. Then, fault feature extraction is conducted using the Inception model to obtain multiscale features. Finally, a Support Vector Machine (SVM) is used to complete the entire fault diagnosis process. The proposed method is comprehensively evaluated using the Sallen–Key bandpass filter circuit and the four-op-amp biquad high-pass filter circuit widely used in electronic systems. The experimental results prove that the proposed method outperforms the existing methods in terms of diagnosis accuracy and reliability. Full article
(This article belongs to the Special Issue Feature Papers in Section "Engineering and Materials" 2024)
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13 pages, 3880 KiB  
Technical Note
Experimental Co-Polarimetric GPR Survey on Artificial Vertical Concrete Cracks by the Improved Time-Varying Centroid Frequency Scheme
by Xuebing Zhang, Junxuan Pei, Xianda Sha, Xuan Feng, Xin Hu, Changle Chen and Zhengchun Song
Remote Sens. 2024, 16(12), 2095; https://doi.org/10.3390/rs16122095 (registering DOI) - 10 Jun 2024
Abstract
The experimental setup is devised to simulate the presence of vertical cracks with varying widths within concrete structures. Co-polarimetric ground-penetrating radar (GPR) surveys are carried out to acquire the “VV” and “HH” polarization data. The time-varying centroid frequency attribute is employed to describe [...] Read more.
The experimental setup is devised to simulate the presence of vertical cracks with varying widths within concrete structures. Co-polarimetric ground-penetrating radar (GPR) surveys are carried out to acquire the “VV” and “HH” polarization data. The time-varying centroid frequency attribute is employed to describe the vertical variation in the center frequency of the radar wave, unveiling a gradual vertical decay in the centroid frequency at the locations of vertical cracks. An improved time-varying centroid frequency attribute based on the adaptive sparse S-transform (ASST) is proposed and tested by a finite-difference time-domain model and co-polarimetric GPR data, which can offer better resolution compared to that of the conventional S-transform. By analyzing the waveform and centroid frequency properties of the two polarizations, we conclude that the “VV” polarization is relatively sensitive to centimeter scale cracks, while the “HH” polarization is more sensitive to millimeter scale cracks. Full article
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16 pages, 592 KiB  
Article
Leuconostoc gelidum Is the Major Species Responsible for the Spoilage of Cooked Sausage Packaged in a Modified Atmosphere, and Hop Extract Is the Best Inhibitor Tested
by Giuseppe Comi, Andrea Colautti, Cristian Edoardo Maria Bernardi, Simone Stella, Elisabetta Orecchia, Francesca Coppola and Lucilla Iacumin
Microorganisms 2024, 12(6), 1175; https://doi.org/10.3390/microorganisms12061175 (registering DOI) - 10 Jun 2024
Abstract
Cooked sausages packaged in a modified atmosphere (MAP: 20% CO2, 70% N2, <0.2% O2) with evident yellow stains were analyzed. The aims of this work were to study the microbial cause of the spoilage and to evaluate different [...] Read more.
Cooked sausages packaged in a modified atmosphere (MAP: 20% CO2, 70% N2, <0.2% O2) with evident yellow stains were analyzed. The aims of this work were to study the microbial cause of the spoilage and to evaluate different antimicrobial compounds to prevent it. Leuconostoc gelidum was identified as the primary cause of the yellow coating in spoiled cooked sausage, as confirmed by its intentional inoculation on slices of unspoiled sausage. Leuconostoc gelidum was the main bacteria responsible for the yellow coating in spoiled cooked sausage, as confirmed by its intentional inoculation on slices of unspoiled sausage. The yellow color was also evident during growth in the model system containing cooked sausage extract, but the colonies on MRS agar appeared white, demonstrating that the food substrate stimulated the production of the yellow pigment. The spoilage was also characterized by different volatile compounds, including ketones, ethanol, acetic acid, and ethyl acetate, found in the spoiled cooked sausage packages. These compounds explained the activity of Leuc. gelidum because they are typical of heterofermentative LAB, cultivated either on food substrates or in artificial broths. Leuc. gelidum also produced slight swelling in the spoiled packages. The efficacy of different antimicrobials was assessed in model systems composed of cooked sausage extract with the antimicrobials added at food product concentrations. The data showed that sodium lactate, sodium acetate, and a combination of sodium lactate and sodium diacetate could only slow the growth of the spoiler—they could not stop it from occurring. Conversely, hop extract inhibited Leuc. gelidum, showing a minimal inhibitory concentration (MIC) of approximately 0.008 mg CAE/mL in synthetic broth and 4 mg CAE/kg in cooked sausage slices. Adding hop extract at the MIC did not allow Leuc. gelidum growth and did not change the sensorial characteristics of the cooked sausages. To our knowledge, this is the first report of the antimicrobial activities of hop extracts against Leuc. gelidum either in vitro or in vivo. Full article
(This article belongs to the Special Issue Food Microbiota and Food Safety)
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28 pages, 12978 KiB  
Article
A Novel Double Closed Loop Control of Temperature and Rotational Speed for Integrated Multi-Parameter Hydro-Viscous Speed Control System (HSCS)
by Kai Zhao, Yuan Wang, Shoukun Wang, Feiyue Gao, Xiang Feng, Hu Shen, Lin Zhang, Liang Wang, Bin Yu and Kaixian Ba
Machines 2024, 12(6), 394; https://doi.org/10.3390/machines12060394 (registering DOI) - 10 Jun 2024
Abstract
Hydro-viscous clutch has already become an inevitable choice for special vehicle transmission in the present and future. As a nonlinear system with a large hysteresis loop, its speed control performance is affected by input rotational speed, lubricating oil temperature, lubrication pressure, and other [...] Read more.
Hydro-viscous clutch has already become an inevitable choice for special vehicle transmission in the present and future. As a nonlinear system with a large hysteresis loop, its speed control performance is affected by input rotational speed, lubricating oil temperature, lubrication pressure, and other factors. The traditional control method cannot adjust the temperature and rotational speed, which will lead to problems of narrow speed range, poor rotational speed stability, and large dynamic load impact. In order to solve the above problems, this paper studies the control method of an integrated multi-parameter hydro-viscous speed control system (HSCS) in a controlled environment. Through the mechanism analysis of the law of HSCS, the influence law of speed and temperature during the system operation is found. The temperature closed loop based on model predictive control (MPC) is introduced to control the rotational speed, and then the traditional PID control results are compensated according to the speed closed loop. Next, a novel double closed loop control method of temperature and rotational speed for HSCS is formed. Finally, the simulating verification is carried out. Compared with the traditional control method, the design method in this paper can adjust the control parameters according to the temperature of the lubricating oil and the input rotational speed and effectively expand the domain of HSCS and the speed control stability. The effective transmission ratio is extended to 0.2~0.8, and the hydro-viscous torque and speed fluctuation under the engine rotational speed fluctuation are reduced by more than 30%. The novel control method of HSCS designed in this paper can effectively improve the influence of input rotational speed and lubricating oil temperature on the speed control performance of HSCS and can be widely used in nonlinear HSCS such as hydro-viscous clutch. Full article
(This article belongs to the Special Issue Control and Mechanical System Engineering)
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