Abstract
The problem of whether oral Herpes simplex virus type 1 (HSV-1) infection provides protection against subsequent genital infection by Herpes simplex virus type 2 (HSV-2) was investigated. Mice were used as models. Following conditions in man, both the oral and genital infections applied were noninjurious. Mice infected orally with HSV-1 were weakly protected against virus ‘take’ following vaginal challenge with HSV-2. Genital ‘takes’ were found in 67% of the immunized mice, as compared with 83% of the controls (protection rate 20%,P=0.002). The course of genital infection in the immunized mice, however, was relatively mild: Lethality decreased from 97% in the controls to 35% in the immunized mice (protection rate 63%,P<0.001). Furthermore, local and neurologic symptoms occurred less frequently. Attempts to isolate the virus from homogenized brain and spinal cord of immunized mice that died after genital challenge with HSV-2 failed in most cases. Also virus could not be recovered from the liver of infected mice, irrespective of the experimental group.
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Baker, M.B., Larson, C.L., Ushijima, R.N., Anderson, F.D.: Resistance of female mice to vaginal infection induced by herpesvirus hominis type 2: Effects of immunization with Mycobacterium bovis, intravenous injection of specific herpesvirus hominis type 2 antiserum, and a combination of these procedures. Infect. Immun.10, 1230–1234 (1974)
Baron, S., Worthing, M.G., Williams, J., Gaines, J.W.: Postexposure serum prophylaxis of neonatal herpes simplex infection of mice. Nature261, 505–506 (1976)
Cappel, R.: Comparison of the humoral and cellular immune responses after immunization with live, UV inactivated herpes simplex virus and a subunit vaccine and efficacy of these immunizations. Arch.Virol.52, 29–35 (1976)
Cook, M.L., Stevens, J.G.: Pathogenesis of herpetic neuritis and ganglionitis in mice. Evidence for intra-axonal transport of infection. Infect. Immun.7, 272–288 (1973)
Douglas, F.G., Jr., Couch, R.B.: A prospective study of chronic herpes simplex virus infection and recurrent herpes labialis in humans. J. Immunol.104, 289–295 (1970)
Dowdle, W.R., Nahmias, A.J., Harwell, R.W., Pauls, F.P.: Association of antigenic types of herpesvirus hominis with site of viral recovery. J. Immunol.99, 974–980 (1967)
Ennis, F.A., Wells, M.: Immune control of herpes simplex virus infection. Cancer Res.34, 1140–1145 (1974)
Kitces, E.N., Morahan, P.S., Tew, J.G., Murray, B.K.: Protection from oral herpes simplex virus infection by a nucleic acid-free virus vaccine. Infect. Immun.16, 955–960 (1977)
Koyama, H., Kasahara, S.: Induction of herpes simplex virus immunity in newborn mice. Infect. Immun.12, 1472–1474 (1975)
Lamm, M.E.: Cellular aspects of IgA. Adv. Immunol.22, 223–279 (1976)
London, W.T., Nahmias, A.J., Naib, Z.M., Fuccillo, D.A., Ellenberg, J.H.: A nonhuman primate model for the study of the cervical oncogenic potential of herpes simplex virus type 2. Cancer Res.34, 1118–1121 (1974)
Lopez, C.: Genetics of natural resistance to herpesvirus infections in mice. Nature258, 152–153 (1975)
Luyet, F., Samra, D., Soneji, A., Marks, M.J.: Passive immunization in experimental herpesvirus hominis infection of newborn mice. Infect. Immun.12, 1258–1261 (1975)
McKendall, R.R.: Efficacy of herpes simplex virus type 1 immunization in protecting against acute and latent infection by herpes simplex virus type 2 in mice. Infect. Immun.16, 717–719 (1977)
Mogensen, S.C., Teisner, B., Andersen, H.K.: Focal necrotic hepatitis in mice as biological marker for differentiation of herpesvirus hominis type 1 and type 2. J. Gen. Virol.25, 151–155 (1974)
Nahmias, A.J., Dowdle, W.R.: Antigenic and biologic differences in herpesvirus hominis. Prog. Med. Virol.10, 110–159 (1968)
Nahmias, A.J., Josey, W.E., Naib, Z.M., Luce, C.F., Duffey, A.: Antibodies to herpesvirus hominis type 1 and 2 in humans. Am. J. Epidemiol.91, 539–546 (1970)
Oakes, J.E.: Role for cell-mediated immunity in the resistance of mice to subcutaneous herpes simplex virus infection. Infect. Immun.12, 166–172 (1975)
Overall, J.C., Kern, E.R., Schlitzer, R.L., Friedman, S.B., Glasgow, L.A.: Genital herpesvirus hominis infection in mice: I. Development of an experimental model. Infect. Immun.11, 476–480 (1975)
Price, R.W., Walz, M.A., Wohlenberg, C., Notkins, A.L.: Latent infection of sensory ganglia with herpes simplex virus: Efficacy of immunization. Science188, 938–940 (1975)
Rager-Zisman, B., Allison, A.C.: Mechanism of immunologic resistance to herpes simplex virus (HSV-1) infection. J. Immunol.116, 35–40 (1976)
Rawls, W.E., Gardner, H.L., Flanders, R. W., Lowry, S.P., Kaufman, R.H., Melnick, J.L.: Genital herpes in two social groups. Am. J. Obstet. Gynecol.110, 682–689 (1971)
Renis, H.E., Eidson, E.E., Mathews, J., Gray, J.E.: Pathogenesis of herpes simplex virus types 1 and 2 in mice after various routes of inoculation. Infect. Immun.14, 571–578 (1976)
Schneweis, K.E.: Serologische Untersuchungen zur Typendifferenzierung des Herpesvirus hominis. Z. Immunitaetsforsch.124, 24–48 (1962)
Schneweis, K.E.: Der cytopathische Effekt des Herpes simplex Virus. Stammdifferenzen, Stabilitaet, Einfluss von Immunserum und Bezichungen zur Pockengroesse. Zentralbl. Bakteriol [Orig. A]186, 467–494 (1962)
Schneweis, K.E.: Die Typen 1 und 2 des Herpes simplex Virus bei verschiedenen Krankheitsbildern. Dtsch. Med. Wochenschr.92, 2313–2314 (1967)
Scriba, M.: Herpes simplex virus infection in guinea pigs: An animal model for studying latent and recurrent herpes simplex virus infection. Infect. Immun.12, 162–165 (1975)
Scriba, M., Bachmeyer, H., Liehl, E.: Protection of animals against primary and recurrent herpes simplex virus infections by various inactivated vaccine preparations. XVth Symposium European Association against Virus Diseases, Amsterdam 6–9 Sept. 1977
Scriba, M.: Protection of guinea pigs against primary and recurrrent genital herpes infections by immunization with live heterologous or homologous herpes simplex virus: Implication for a herpesvirus vaccine. XVth Symposium European Association against Virus Diseases, Amsterdam, 6–9 Sept. 1977
Skinner, G.R.B., Williams, D.R., Whitney, J.E., Harding, M., Bodfish, K., Bodfish, P.: Progress towards development of a herpes simplex virus vaccine using mice as an experimental system. XVth Symposium European Association against Virus Diseases, Amsterdam, 6–9 Sept. 1977
Skinner, G.R.B., Hartley, C., Whitney, J.E.: Prevalence of type-specific antibody against type 1 and type 2 herpes simplex virus in women with abnormal cervical cytology; evidence towards pre-pubertal vaccination of seronegative female subjects. Arch. Virol.54, 211–221 (1977)
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Sturn, B., Schneweis, KE. Protective effect of an oral infection with Herpes simplex virus type 1 against subsequent genital infection with Herpes simplex virus type 2. Med Microbiol Immunol 165, 119–127 (1978). https://doi.org/10.1007/BF02122747
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DOI: https://doi.org/10.1007/BF02122747