CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function
Figure 9
Significance and direction of effect for synaptic CELF targets enriched between cell body and neuropil.
This figure, together with Table 3, considers the subset of 142 CELF4 targets selectively enriched for differential expression between hippocampal CA1 cell body vs. neuropil, as derived from the GO categories “Regulation of synaptic plasticity”, “Synapse part” and “Cell adhesion”, from Figure 8. The relative significance is shown for the three proxy categories (non-solid columns) and various subcategories (solid columns) of molecular function (panel A) and subcellular location (panel B), using the difference in the log p value derived from Fisher's Exact test for each (Δ log p), as an indicator (Y-axis). Categories were selected based on having at least 12 CELF4 targets in each, and also only one category is shown if closely-related GO categories had the same members in them (e.g. “transporter activity” was shown but not “ion transporter activity”, “transmembrane transporter activity” which had the same members). For molecular function, the largest effect is seen for proteins that associate with “lipid binding”, transporter activity” and “channel activity”, with the next category being almost an order of magnitude less significant. For subcellular localization, the subcategories that had the largest effect were “synaptic membrane”, and “presynaptic membrane”, although various other structures were almost as significant. The full list of genes, categories, sample sizes and expression data can be found in File S8.