Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans
Figure 8
Correlation of the expression of FKBP51, pAkt, and Beclin1 with clinical antidepressant response, and of the autophagic markers Beclin1, pAkt, and LC3B-II/I with FKBP51.
Beclin1, FKBP51, LC3B-II/I, and pAktS473/Akt levels were determined in PBMCs from inpatients with depression at admission (n = 51). (A–C) Expression values of Beclin1 (A), pAktS473/Akt (B), and FKPP51 (C) are correlated with the response to antidepressant (AD) treatment expressed as percent change in total score on the 21-item HDRS between admission and after 6 wk of treatment. (D–F) Expression values of the autophagy pathway markers Beclin1 (D), pAktS473/Akt (E), and LC3B-II/I (F) are correlated with the expression levels of FKBP51.