Impact of AT2 Receptor Deficiency on Postnatal Cardiovascular Development
Figure 7
Effects of angiotensin II (Ang II, 10−7 mol/L), isoprenaline (ISO, 10−6 mol/L), or the combination of both on sarcomere shortening (A) and calcium transients (B) of isolated cardiomyocytes from WT and KO mice (n = 10–36 cardiomyocytes from both three KO and WT hearts were analysed, respectively).
** P<0.05 vs. basal sarcomere shortening of WT or KO cardiomyocytes, # P<0.05 vs. sarcomere shortening of WT cardiomyocytes treated with isoprenaline in the presence of angiotensin II, * P<0.05 vs. basal WT calcium % peak height, $ P<0.05 vs. basal KO calcium % peak height, # P<0.05 vs. calcium % peak height of WT cardiomyocytes treated with isoprenaline in the presence of angiotensin II. Data are shown as mean ± SEM. C) Representative recordings of sarcomere shortening (black/grey lines) and calcium transients (pink/red lines) in cardiomyocytes derived from KO and WT mice.