Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans
Figure 7
Effects of dexamethasone and of antidepressants on autophagic pathway components in human PBMCs correlate with FKBP51.
(A and B) PBMCs were collected from healthy subjects (n = 14) before and 6 h after the intake of 1.5 mg of DEX, and proteins were analyzed. Each dot represents the DEX-induced change in FKBP51 and the expression change of the respective protein (Beclin 1 [A] and pAktS473 [B]) in the PBMCs of one individual. (C–F) Levels of FKBP51 and Beclin1 (C), pAktS473 (D), LC3B-II/I (E), and Atg12 (F) in PBMCs from healthy men (n = 21) cultivated ex vivo and treated with PAR (0.365 µM, 48 h). Plots depict protein changes upon treatment with antidepressant compared to vehicle-treated cells in correlation to FKBP51. Each dot represents the level of FKBP51 and the expression change of the respective protein in the PBMCs from one individual.