Toxicological Profile of Ultrapure 2,2′,3,4,4′,5,5′-Heptachlorbiphenyl (PCB 180) in Adult Rats
Figure 6
Densitometric analysis of Western blots for total p53 (A), p53 Ser15 (B), pChk2 Thr68 (C) and γH2AX Ser139 (D) protein in livers of females.
Tumor suppressor protein p53 and the DNA damage signaling markers were dose-dependently increased only in females. Each column represents mean ± SD (n = 5) as percent of control after adjustment to the loading control (Cdk2). Data was obtained from at least three independent analyses.