Efficacy of a Metalloproteinase Inhibitor in Spinal Cord Injured Dogs
Figure 6
Serum MMP-2/MMP-9 activity pre- and post-drug delivery.
Dogs were first randomized into 3 treatment groups, and serum was obtained prior to administration of saline, DMSO, or GM6001 (panel A). There were no differences in serum MMP-2/MMP-9 activity among treatment groups at the time of admission (panel A); however, at day 3, there was a significant (P = 0.0482) difference in serum activity between GM6001-treated dogs and the other treatment groups (panel B). See Figure 5 for a description of box-and-whisker plots. Groups marked with different letters differ significantly (P<0.05).