A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics
Figure 6
Network of degree of pleiotropy between phenotypes.
An arrow runs from vertex i to vertex j if and only if by conditioning on p < 5 × 10−6 for the conditional phenotype j we can increase the threshold for significance for the p value for the principal phenotype i from 5 × 10−8 to 4 × 10−7 or greater. Edges are thickened if the cutoff could be increased more than this. The threshold 4 × 10−7 was selected as the minimum value for which the network is weakly connected; that is, having an arrow to or from each edge.