Trichloroethylene-Induced Gene Expression and DNA Methylation Changes in B6C3F1 Mouse Liver
Figure 5
Global DNA methylation status of the liver of mice exposed to TCE.
A–C) Bisulfite sequencing of the LINE-1, LAP-LTR and SINE B1 repetitive elements in the liver of mice treated with TCE at 0 or 1000 mg/kg b.w. Open and closed circles indicate unmethylated and methylated CpG sites respectively. Some sites are absent from the sequences in some clones due to mutations in the particular copies of the repetitive sequences. Percent methylation is shown in parentheses. D) The content of 5-mC detected by LC-MS/MS. (n = 5).