Toxicological Profile of Ultrapure 2,2′,3,4,4′,5,5′-Heptachlorbiphenyl (PCB 180) in Adult Rats
Figure 5
BMD analysis of serum free T4 (A), serum free T3 (B) and serum TSH (C) in males (triangles) and females (circles).
T4 and T3 were dose-dependently decreased in both genders, and TSH increased in males only. Small symbols indicate individual samples, large symbols the group mean; the vertical dotted line indicates the dose (CED) with 5% decrease or increase (CES -0.05) compared to background (a parameter). (Optimal models used for CED calculations as shown in Table 2 were determined separately for females and males and are not necessarily the same shown here).