CELF4 Regulates Translation and Local Abundance of a Vast Set of mRNAs, Including Genes Associated with Regulation of Synaptic Function
Figure 5
Validation of CELF4 genotype-dependent abundance changes of select CELF4 target mRNAs.
The white column in each panel shows relative fold change (expressed as 2ΔΔCt –Methods) between Celf4 null and wt for dissected cerebral cortex (panel A), or hippocampus (panel B), respectively by quantitative real-time RT-PCR (qPCR). In both panels filled columns show the ratio of normalized average fluorescence between Celf4 null and wt from the whole brain microarray. For qPCR data, statistical significance was determined using Student's |t| test: *p<0.1, **p<.05, ***p<0.01. Underlined gene symbols highlight genes tested in both tissues. The ΔΔCt data for qPCR and subset of microarray data can be found in File S4.