A Comprehensive Map of Mobile Element Insertion Polymorphisms in Humans
Figure 5
a–c) Uncorrected allele count spectra. Non-reference MEI (blue) and reference MEI (red): a) CEU, b) YRI, c) CHBJPT. Loci with 25 or more genotyped samples were included. A random subset of 25 samples was selected for any locus with more than 25 genotyped samples. Gray dashed lines are based on neutral model fits from the full MEI spectra, modified to account for the respective ascertainment conditions, (θ/2N) for reference MEI, (θ/i)(2N−i)/(2N) for non-reference MEI, where N = 25 is the number of samples in the spectrum. d–f) MEI allele count spectra. d) CEU, e) YRI, f) CHBJPT. The spectra are corrected for each detection mode sensitivity and genotyping efficiency according to the expression in the legend. Gray dashed line is a fit to θ/i, where i is the allele count and θ is the diversity parameter. Only counts in the range of 7≤i≤47 were used in the fit (bins with vertical one sigma error bars).