Role of Transmitted Gag CTL Polymorphisms in Defining Replicative Capacity and Early HIV-1 Pathogenesis
Figure 4
Rare polymorphisms have a significantly greater impact on RC.
(A) In an exploratory analysis, rare fitness reducing polymorphisms, occurring in less than 10 out of 149 of the sequences tested, were found to decrease fitness to a significantly greater degree than more common fitness decreasing mutations (Mann Whitney U test, p = 0.002). The y-axis depicts the impact of the polymorphism on RC relative to the median RC of all viruses (∼1.5) (B) Rare fitness increasing polymorphisms, occurring in less than 10 out of 149 of the sequences tested, were found to increase fitness to a significantly greater degree than more common ones (Mann Whitney U test, p = 0.0002).