A Novel TRPC6 Mutation That Causes Childhood FSGS
Figure 4
Increase in Ca2+ current in mutantsN143S, M132T and M132T/N143S.
A: Inward current of wt TRPC6 and the mutants measured at −120 mV in the presence of 100 µM CCH. Inward current level was close to 0 pA level in NMDG solution, and increased after the cell was exposed to 10 mM calcium/NMDG solutions. Note the significant larger calcium current amplitude of M132T and M132T/N143S in comparison with wt TRPC6 and M143S. B: Averaged current amplitude of wt TRPC6, N143S, M132T, and M132T/N143S at −120 mV (mean±SEM, n = 4−7). (**: p<0.01 in comparison with wt TRPC6).