Khellin and Visnagin Differentially Modulate AHR Signaling and Downstream CYP1A Activity in Human Liver Cells
Figure 1
Visnagin and khellin stimulate XRE-driven luciferase activity in AZ-AHR cells.
Stably transfected AZ-AHR cells were treated for 24 h with visnagin (VIS; 0.001 µM-20 µM), khellin (KHEL, 0.001 µM-20 µM), 5 µM 3MC and/or vehicle (DMSO; 0.1% v/v). Analyses were performed in four independent experiments and are expressed as fold induction over untreated cells. * - Value is significantly different from DMSO-treated cells (p < 0.05).