Integration of Mouse and Human Genome-Wide Association Data Identifies KCNIP4 as an Asthma Gene
Figure 1
Mouse association study (in pink): (A) Baseline AHR slope measures were obtained for 31 mouse strains, and these were (B) used to perform an association study using EMMA software. (C) Mouse genes near or containing SNPs with p-values <0.001 were selected for follow-up study in human GWAS datasets. Integration of mouse results with human data (in blue): (D) HomoloGene maps were used to obtain human homologous genes corresponding to the top mouse genes. (E) Genes with SNPs having p-values <0.001 in the combined EVE meta-analysis or within race/ethnic specific GWAS were selected for (F) replication in other human GWAS.