Abstract
The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.
Similar content being viewed by others
References
Rosenberg SA, Diamond HD, Carver LF (1961) Lymphosarcoma. A review of 1269 cases. Medicine 40:31–84
Chorlton I, Karnei RF, King FM, Norris HJ (1974) Primary malignant reticuloendothelial disease involving the vagina, cervix, and corpus uteri. Obstet Gynecol 44:735–748
Aozasa K, Saeki K, Ohsawa M, Horiuchi K, Mishima K, Tsujimoto M (1993) Malignant lymphoma of the uterus. Cancer 27:1959–1964
Harris NL, Scully RE (1984) Malignant lymphoma and granulocytic sarcoma of the uterus and vagina. Cancer 53:2530–2545
Lennert K, Mohri N, Stein H, Kaiserling E (1975) The histopathology of malignant lymphoma. Br J Haematol 31[Suppl]:193–203
McKelvey EM, Gottlieb JA, Wilson HE, et al (1976) Hydrox-yldaunomycin (adriamycin) combination chemotherapy in malignant lymphoma. Cancer 38:1484–1501
Cordell JL, Falini B, Erber WN, et al (1984) Immunoenzymatic labeling of monoclonal antibodies using complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 32:219–229
Feller AC, Wacker H-H, Moldenhauer G, Radzun HJ, Parwaresch MR (1987) Monoclonal antibody Ki-B3 detects a formalin resistent antigen on normal and neoplastic B-cells. Blood 70:629–636
Hansmann ML, Wacher H-H, Gralla J, et al (1991) Ki-B5:A monoclonal antibody unrelated to CD 45 recognizes normal and neoplastic human B cells in routine paraffin sections. Blood 77:809–817
Cartun RW, Coles FB, Pastuszak WT (1987) Utilization of monoclonal antibody L26 in the identification and confirmation of B-cell lymphomas. A sensitive and specific marker applicable to formalin- and B5-fixed, paraffembedded tissues. Am J Pathol 129:415–421
Kreipe H, Heidebrecht HJ, Hansen S, et al (1993) A new proliferation-associated nuclear antigen detectable in paraffin-embedded tissues by the monoclonal antibody Ki-S1. Am J Pathol 142:3–9
Kreipe H, Wacker H-H, Heidebrecht HJ, et al (1993) Determination of the growth fraction in Non-Hodgkin's-Iymphomas by monoclonal antibody Ki-S5 directed against a formalin-resistant epitope of the Ki-67 antigen. Am J Pathol 142:1689–1694
Mason DY, Cordell J, Brwon M, et al (1989) Detection of T cells in paraffin wax-embedded tissue using antibodies against a peptide sequence from the CD 3 antigen. J Clin Pathol 42:1194–1200
Radzun HJ, Hansmann M-L, Heidebrecht HJ, et al (1991) Detection for a monocyte/macrophage differentiation antigen in routinely processed paraffin-embedded tissues by monoclonal antibody Ki-M1P. Lab Invest 65:306–315
Broekmans FJ, Swartjes JM, Van der Valk P, et al (1993) Primary malignant lymphoma of the uterus: localization in a cervical polyp. Eur J Obstet Gynecol Reprod Biol 48:215–219
Weseley AC, Berrigan MW (1958) Reticulum cell sarcoma of the vagina. Obstet Gynecol 11:192–195
Jones SE, Fuchs Z, Bull M (1973) Non-Hodgkin's lymphomas. IV clinicopathologic correlation in 405 cases. Cancer 31:806–823
Brittinger G, Bartels H, Common E (Kiel Lymphoma Study Group) (1984) Clinical and prognostic relevance of the Kiel classification of non-Hodgkin's lymphomas: results of a prospective multicenter study by the Kiel lymphoma study group. Hematol Oncol 2:269–306
Muntz HG, Ferry JA, Flynn D, Fuller AF, Tarraza HM (1991) Stage IE primary malignant lymphomas of the uterine cervix. Cancer 68:2023–2032
Perren T, Farrant M, McCarthy K, Harper P, Wiltshaw E (1992) Lymphomas of the cervix and upper vagina: a report of five cases and a review of the literature. Gynecol Oncol 44:87–95
Calubinski K, Breitenecker G, Tatra G (1992) Maligne Lymphome an Vulva und Vagina. Geburtshilfe Frauenheilkd 52:630–631
Bickel DA, Bennet JR, Bend S (1954) Rare mesodermal tumors of the uterus and vagina. Am J Obstet Gynecol 67:1257–1264
Buchler DA, Kline JC (1972) Primary lymphoma of the vagina. Obstet Gynecol 40:235–237
Cantone G (1954) Sul reticulo sarcoma vaginale. Riv Ital Ginecol 37:3–17
International Federation of Gynecology and Obstetrics (1971) Classification and staging of malignant tumors in the female pelvis. Acta Obstet Gynecol Scand 50:1–7
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Höffkes, H.G., Schumann, A., Uppenkamp, M. et al. Primary non-Hodgkin's lymphoma of the vagina case report and review of the literature. Ann Hematol 70, 273–276 (1995). https://doi.org/10.1007/BF01784047
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01784047