Identification of a secreted proline racemase as a Trypanosoma cruzi B-cell mitogen provides mechanistic insight into chronic Chagas disease as well as a potential new drug target (890–897 ).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bener, Z. & Gazzinelli, R.T. Immunological control of Trypanosoma cruzi infection and pathogenesis of Chagas' disease. Int. Arch. Allergy Immunol. 114, 103– 110 (1997).
Minoprio, P. et al. Most B cells in acute Trypanosoma cruzi infection lack parasite specificity. Scand. J. Immunol. 28, 553–561 (1988).
Reina-San-Martin, B. et al. A B-cell mitogen from a pathogenic trypanosome is a novel eukaryotic proline racemase. Nature Med. 6, 890–897 (2000).
Cordeiro da Silva, A. et al. A 24 kDa Trypanosoma cruzi antigen is a B cell activator . Immunology 94, 189–196 (1998).
Van Voorhis, W.C. et al. Molecular mimicry by Trypanosoma cruzi: the FL-160 epitope that mimics mammalian nerve can be mapped to a 12-amino acid peptide . Proc. Natl. Acad. Sci. USA 88, 5993– 5997 (1991).
Minoprio, P. et al. Xid immunodeficiency imparts increased parasite clearance and resistance to pathology in experimental Chagas' disease. Int. Immunol. 3, 427–433 ( 1991).
Tarleton, R.L. et al. “Autoimmune rejection” of neonatal heart transplants in experimental Chagas' disease is a parasite-specific response to infected tissue. Proc. Natl. Acad. Sci. USA 94, 3932 –3937 (1997).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kelly, J. A B-cell activator in Chagas disease. Nat Med 6, 865–866 (2000). https://doi.org/10.1038/78618
Issue Date:
DOI: https://doi.org/10.1038/78618