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Receptors for bradykinin in murine peritoneal macrophages: Modulation of short-term spreading

  • Proceedings of the 3rd European Workshop on Inflammation, Paris, 2–3 March 1981
  • Inflammation Revisited: Cellular Aspects
  • Published:
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Abstract

The order of potency of bradykinin (bk) and four analogues, with respect to their modulation of peritoneal macrophage short-term spreading, suggests the presence of two peptide receptors in these cells which are responsible for antagonistic effects. Spreading inhibition and stimulation are mediated by the B1- and B2-types respectively. The implications of these results are highlighted in view of the hypothesis that the anti-inflammatory compound of the 1500−1000 molecular weight peptide fraction purified from malignant cell culture supernatants could be a kinin metabolite and a feedback mediator of inflammatory reactions.

Resume

L'effet exercé par la bradykinine (BK) et quatre analogues (kallidine (Lys-BK), Met-Lys-BK,1–8octa-BK, tyr8 (Me)-BK) sur l'étalement des macrophages péritonéaux de souris, suggère la présence de deux types de récepteurs sur la membrane de ces cellules. La stimulation des récepteurs de type B1 empêcheriat l'étalement des macrophages tandis que celle des récepteurs de type B2 favoriserait le phénomène. Les résultats obtenus confirmeraient l'hypothèse selon laquelle la fraction peptidique anti-inflammatoire (ak) purifiée à partir du surnageant de cellules tumorales malignes en culture serait un métabolite des kinines

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Author notes

  1. K. -W. Stahl

    Present address: Institut für Pathologie, Universität Freiburg, Albertstrasse 19, D-7800, Freiburg, BRD

Authors and Affiliations

  1. Hôpital Paul Brousse: I.C.I.G. (I.N.S.E.R.M. U-50), 16, av. Paul-Vaillant-Couturier, F-94800, Villejuif, France

    K. -W. Stahl

  2. Hôpital Cochin: Département de Pharmacologie, 27 rue du Fg. Saint-Jacques, F-75014, Paris, France

    M. Roch-Arveiller & J. P. Giroud

  3. Département de Physiologie et de Pharmacologie, Ecole de Médecine, Université de Sherbrooke, J1H 5N4, Sherbrooke, P.Q., Canada

    D. Regoli

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  1. K. -W. Stahl
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  2. M. Roch-Arveiller
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  3. D. Regoli
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  4. J. P. Giroud
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Stahl, K.W., Roch-Arveiller, M., Regoli, D. et al. Receptors for bradykinin in murine peritoneal macrophages: Modulation of short-term spreading. Agents and Actions 11, 624–627 (1981). https://doi.org/10.1007/BF01978768

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  • DOI: https://doi.org/10.1007/BF01978768

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