In:
ChemistrySelect, Wiley, Vol. 5, No. 15 ( 2020-04-23), p. 4755-4760
Abstract:
In this approach we applied a green synthetic protocol for the preparation of a novel series of imidazotriazole derivatives under solvent free conditions and shorter reaction times utilizing the reactive 2‐thioxoimidazolidinone derivative 1 as a starting substrate. Different substituted imidazo[2,1‐c][1,2,4] triazolone derivatives 2 – 4 , 6 and imidazo[1,2‐b][1,2,4] triazolone derivatives 8 – 10 , 12 , 13 , 15 , 16 and 18 were synthesized. We carried out the synthesis of the open chain analogues phenylimidazolidin‐2‐ylidenepicolinohydrazide 5 , dihydroimidazolylacetamide 11 , imidazolylpicolinamide 14 , pentahydroxyhexylideneaminoimidazol‐5‐one derivative 17 , dihydroimidazolyl‐N,N‐dimethylformimidamide 19 and the dihydroimidazo[1,2‐b][1,2,4] triazepine‐7‐carbonitrile 20 . The synthetic methods involved mainly fusion of compound 1 with the appropriate reagents. The in vitro anticancer evaluation at the National Cancer Institute (NCI), USA at a single dose (10 −5 M) in full NCI 60 cell panel revealed that a significant inhibition for some cancer cells was observed with compounds 11 and 17 – 19 (38–67.5 % inhibition).These novel compounds displayed appreciable anticancer activities against different cancer cell lines including leukemia, colon cancer, melanoma, ovarian cancer, renal cancer and non‐small cell lung cancer cell lines.
Type of Medium:
Online Resource
ISSN:
2365-6549
,
2365-6549
DOI:
10.1002/slct.201904624
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2844262-3
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