GLORIA — GEOMAR Library Ocean Research Information Access

1

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Acute HIV-1 Infection in Patients with Hemophilia B Treated with β-Propiolactone-UV-lnactivated Clotting Factor

Kleim, Jörg-Peter ; Bailly, Elke ; Schneweis, Karl Eduard ; [weitere]

Georg Thieme Verlag KG ; 1990

In: Thrombosis and Haemostasis Vol. 64, No. 02 ( 1990), p. 336-337

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In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 64, No. 02 ( 1990), p. 336-337

Materialart: Online-Ressource

ISSN: 0340-6245 , 2567-689X

URL: Article

DOI: 10.1055/s-0038-1647314

Sprache: Englisch

Verlag: Georg Thieme Verlag KG

Publikationsdatum: 1990

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2

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RECOMMENDATIONS ON HOME TREATMENT OF HEMOPHILIAS

Allain, Jean-Pierre ; Blombäck, Margareta ; Brackmann, Hans-Hermann ; [weitere]

Wiley ; 2009

In: Scandinavian Journal of Haematology Vol. 19, No. S31 ( 2009-04-24), p. 75-77

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In: Scandinavian Journal of Haematology, Wiley, Vol. 19, No. S31 ( 2009-04-24), p. 75-77

Materialart: Online-Ressource

ISSN: 0036-553X

URL: Article

DOI: 10.1111/j.1600-0609.1977.tb01545.x

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2009

ZDB Id: 2027114-1

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3

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Identification of Genetic Predispositions Related to Ionizing Radiation in Primary Human Skin Fibroblasts From Survivors of Childhood and Second Primary Cancer as Well as Cancer-Free Controls: Protocol for the Nested Case-Control Study KiKme

Marron, Manuela ; Brackmann, Lara Kim ; Schwarz, Heike ; [weitere]

JMIR Publications Inc. ; 2021

In: JMIR Research Protocols Vol. 10, No. 11 ( 2021-11-11), p. e32395-

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In: JMIR Research Protocols, JMIR Publications Inc., Vol. 10, No. 11 ( 2021-11-11), p. e32395-

Kurzfassung: Therapy for a first primary neoplasm (FPN) in childhood with high doses of ionizing radiation is an established risk factor for second primary neoplasms (SPN). An association between exposure to low doses and childhood cancer is also suggested; however, results are inconsistent. As only subgroups of children with FPNs develop SPNs, an interaction between radiation, genetic, and other risk factors is presumed to influence cancer development. Objective Therefore, the population-based, nested case-control study KiKme aims to identify differences in genetic predisposition and radiation response between childhood cancer survivors with and without SPNs as well as cancer-free controls. Methods We conducted a population-based, nested case-control study KiKme. Besides questionnaire information, skin biopsies and saliva samples are available. By measuring individual reactions to different exposures to radiation (eg, 0.05 and 2 Gray) in normal somatic cells of the same person, our design enables us to create several exposure scenarios for the same person simultaneously and measure several different molecular markers (eg, DNA, messenger RNA, long noncoding RNA, copy number variation). Results Since 2013, 101 of 247 invited SPN patients, 340 of 1729 invited FPN patients, and 150 of 246 invited cancer-free controls were recruited and matched by age and sex. Childhood cancer patients were additionally matched by tumor morphology, year of diagnosis, and age at diagnosis. Participants reported on lifestyle, socioeconomical, and anthropometric factors, as well as on medical radiation history, health, and family history of diseases (n=556). Primary human fibroblasts from skin biopsies of the participants were cultivated (n=499) and cryopreserved (n=3886). DNA was extracted from fibroblasts (n=488) and saliva (n=510). Conclusions This molecular-epidemiological study is the first to combine observational epidemiological research with standardized experimental components in primary human skin fibroblasts to identify genetic predispositions related to ionizing radiation in childhood and SPNs. In the future, fibroblasts of the participants will be used for standardized irradiation experiments, which will inform analysis of the case-control study and vice versa. Differences between participants will be identified using several molecular markers. With its innovative combination of experimental and observational components, this new study will provide valuable data to forward research on radiation-related risk factors in childhood cancer and SPNs. International Registered Report Identifier (IRRID) DERR1-10.2196/32395

Materialart: Online-Ressource

ISSN: 1929-0748

URL: Article

DOI: 10.2196/32395

Sprache: Englisch

Verlag: JMIR Publications Inc.

Publikationsdatum: 2021

ZDB Id: 2719222-2

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4

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Human Recombinant DNA–Derived Antihemophilic Factor (Factor VIII) in the Treatment of Hemophilia A

Schwartz, Richard S. ; Abildgaard, Charles F. ; Aledort, Louis M. ; [weitere]

Massachusetts Medical Society ; 1990

In: New England Journal of Medicine Vol. 323, No. 26 ( 1990-12-27), p. 1800-1805

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In: New England Journal of Medicine, Massachusetts Medical Society, Vol. 323, No. 26 ( 1990-12-27), p. 1800-1805

Materialart: Online-Ressource

ISSN: 0028-4793 , 1533-4406

URL: Article

DOI: 10.1056/NEJM199012273232604

RVK:

XA 10000

Sprache: Englisch

Verlag: Massachusetts Medical Society

Publikationsdatum: 1990

ZDB Id: 1468837-2

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5

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OTOLOGY AND NEUROTOLOGY: CONTROL OF VENOUS BLEEDING IN OTOLOGIC SURGERY

MOLOY, PETER J. ; BRACKMANN, DERALD E.

Wiley ; 1986

In: The Laryngoscope Vol. 96, No. 5 ( 1986-05), p. 580-582

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In: The Laryngoscope, Wiley, Vol. 96, No. 5 ( 1986-05), p. 580-582

Materialart: Online-Ressource

ISSN: 0023-852X

URL: Article

DOI: 10.1288/00005537-198605000-00021

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 1986

ZDB Id: 2026089-1

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6

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Ossifying Hemangioma of the Internal Auditory Canal

Brackmann, Derald E ; Weisskopf, Peter A ; Lo, William W. M

Ovid Technologies (Wolters Kluwer Health) ; 2005

In: Otology & Neurotology Vol. 26, No. 6 ( 2005-11), p. 1239-1240

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In: Otology & Neurotology, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 6 ( 2005-11), p. 1239-1240

Materialart: Online-Ressource

ISSN: 1531-7129

URL: Article

DOI: 10.1097/01.mao.0000194893.10850.ca

Sprache: Englisch

Verlag: Ovid Technologies (Wolters Kluwer Health)

Publikationsdatum: 2005

ZDB Id: 2058738-7

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7

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Home Care of Hemophilia in West Germany

Brackmann, Hans-Hermann ; Hofmann, Peter ; Etzel, Franz ; [weitere]

Georg Thieme Verlag KG ; 1976

In: Thrombosis and Haemostasis Vol. 35, No. 03 ( 1976), p. 544-552

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In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 35, No. 03 ( 1976), p. 544-552

Materialart: Online-Ressource

ISSN: 0340-6245 , 2567-689X

URL: Article

DOI: 10.1055/s-0038-1647995

Sprache: Englisch

Verlag: Georg Thieme Verlag KG

Publikationsdatum: 1976

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8

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Regulation of human factor IX expression using doxycycline-inducible gene expression system

Wang, Xiaomin ; Siemetzki, Ulrike ; Albert, Thilo ; [weitere]

Georg Thieme Verlag KG ; 2003

In: Thrombosis and Haemostasis Vol. 90, No. 09 ( 2003), p. 398-405

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In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 90, No. 09 ( 2003), p. 398-405

Kurzfassung: Following substitution therapy with human factor IX (hFIX) concentrate, therapy of haemophilia B by viral gene transfer has become an attractive alternative therapy in recent years. However, high doses of expressed hFIX, which can already be achieved in animal studies, may cause thrombosis in humans (van Hylckama Vlieg et al., 2000). Thus, it should be possible to maintain transgene expression within the therapeutic range. Therefore, we inserted elements of the tetracycline (Tet)-dependent Tet-On gene regulatory system into replication deficient adenovectors. The new system consists of two adenovec-tors: a response vector expressing hFIX (Ad5. TRE.hFIX), and a regulator vector expressing a second generation reverse tetracycline transactivator controlled by a CMV- (Ad5. CMV.rtTA) or human alpha1-antitrypsin-promoter (Ad5.hAAT.rtTA). Expression studies in four human cell lines showed high expression of hFIX from Ad5. TRE.hFIX in all cell lines in combination with Ad5. CMV.rtTA regulator vector, but only high specific expression in HepG2-cells in combination with Ad5.hAAT.rtTA regulator vector. Additionally, up- and down-regulation of hFIX expression could be demonstrated in vitro with the Ad5. TRE.hFIX/Ad5. CMV.rtTA combination and modulating doxycycline concentrations. When SCID-mice were infected with the Ad5. TRE.hFIX/Ad5. CMV.rtTA combination, up- and down-regulation of hFIX expression was achieved by oral doses of doxycycline for a period of at least two months. Replacement of the Ad5. CMV.rtTA vector by the Ad5.hAAT.rtTA vector showed minimal expression of hFIX in vivo. Although hFIX expression showed a slow and gradual decrease over time in vivo with the Ad5. CMV.rtTA vector, it remained within the therapeutic range. To date, regulation of hFIX has not been described in this way.

Materialart: Online-Ressource

ISSN: 0340-6245 , 2567-689X

URL: Article

DOI: 10.1160/TH03-01-0010

Sprache: Englisch

Verlag: Georg Thieme Verlag KG

Publikationsdatum: 2003

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9

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Achilles tendon lengthening for ankle equinus deformity in hemophiliacs: 23 patients followed for 1–24 years

Wallny, Thomas ; Brackmann, Hans ; Kraft, Clayton ; [weitere]

Medical Journals Sweden AB ; 2006

In: Acta Orthopaedica Vol. 77, No. 1 ( 2006-01), p. 164-168

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In: Acta Orthopaedica, Medical Journals Sweden AB, Vol. 77, No. 1 ( 2006-01), p. 164-168

Materialart: Online-Ressource

ISSN: 1745-3674 , 1745-3682

URL: Article

DOI: 10.1080/17453670610045867

RVK:

XA 12700

Sprache: Englisch

Verlag: Medical Journals Sweden AB

Publikationsdatum: 2006

ZDB Id: 2187223-5

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10

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1,1′‐Bi(trishomobarrelenyl) – Synthesis and Chiroptic Properties

de Meijere, Armin ; Rauch, Karsten ; Schrader, Bernhard ; [weitere]

Wiley ; 2009

In: European Journal of Organic Chemistry Vol. 2009, No. 7 ( 2009-03), p. 1048-1052

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In: European Journal of Organic Chemistry, Wiley, Vol. 2009, No. 7 ( 2009-03), p. 1048-1052

Kurzfassung: 1,1′‐Bi( endo , exo , syn ‐pentacyclo[3.3.3.0 2,4 .0 6,8 .0 9,11 ]undecyl)[1,1′‐bi(trishomobarrelenyl)] ( 4 ) has been prepared as a 1:1 mixture of its meso ‐ and d , l ‐diastereomers in six steps from trishomobarrelene 1 via the amine 5 , the N , N ′‐bis(trishomobarrelenyl)sulfamide 6 and the 1,2‐(trishomobarrelenyl)diazene 7 in 16 % overall yield. Crystals of meso ‐ 4 were grown from a pentane solution of the mixture and subjected to an X‐ray structure analysis. The (+)‐ and the (–)‐enantiomer were isolated by HPLC on a chiral‐phase column. They exhibited significantly enhanced molar optical rotations which are consistent with the presence of three helically arranged 1,2‐dicyclopropylethane units in their skeletons. The absolute configuration of the (+)‐enantiomer was assigned on the basis of DFT computed optical rotations of both enantiomers to be all ‐( S ).(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

Materialart: Online-Ressource

ISSN: 1434-193X , 1099-0690

URL: Issue

URL: Article

DOI: 10.1002/ejoc.v2009:7

DOI: 10.1002/ejoc.200801111

RVK:

VA 4073

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2009

ZDB Id: 1475010-7

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