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  • 1
    Online Resource
    Online Resource
    Pharmacokinetic/Pharmacodynamic Evaluation of the NHE Inhibitor Eniporide
    Wiley ; 2001
    In:  The Journal of Clinical Pharmacology Vol. 41, No. 2 ( 2001-02), p. 139-148
    Details
    In: The Journal of Clinical Pharmacology, Wiley, Vol. 41, No. 2 ( 2001-02), p. 139-148
    Type of Medium: Online Resource
    ISSN: 0091-2700
    URL: Article
    DOI: 10.1177/00912700122009944
    RVK:
    XA 52835
    Language: English
    Publisher: Wiley
    Publication Date: 2001
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    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Stationäre Gerontopsychosomatik : Ergebnisse zum Behandlungsaufwand und Behandlungserleben
    Hogrefe Publishing Group ; 2002
    In:  Zeitschrift für Gerontopsychologie & -psychiatrie Vol. 15, No. 1 ( 2002-03), p. 33-45
    Details
    In: Zeitschrift für Gerontopsychologie & -psychiatrie, Hogrefe Publishing Group, Vol. 15, No. 1 ( 2002-03), p. 33-45
    Abstract: Inpatient Gerontopsychosomatics: Investigation of Dosis and Experience of Treatment Summary: With the increase of elderly patients in psychosomatic clinics, the question arises, if the well established concept of treatment works with this group of patients. An empirical study is presented, where 189 elderly patients ( 〉 55 years) and 190 younger patients ( 〈 55 years) are included. They are analysed with different questionnaires, included also the documentation of treatment. The explorative questions were, what about the dosis and utilization of treatment, experience of treatment and valuing of treatment. We find many differences between elderly and younger patients, there are some results of relevance for developing an gerontopsychosomatic concept, wich are discussed.
    Type of Medium: Online Resource
    ISSN: 1011-6877 , 1664-2899
    URL: Article
    DOI: 10.1024//1011-6877.15.1.33
    RVK:
    XA 10000
    RVK:
    CL 1000
    Language: English
    Publisher: Hogrefe Publishing Group
    Publication Date: 2002
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  • 3
    Online Resource
    Online Resource
    Microstructure Observations of Turbulent Mixing in a Partially Mixed Estuary. Part I: Dissipation Rate
    American Meteorological Society ; 2000
    In:  Journal of Physical Oceanography Vol. 30, No. 6 ( 2000-06), p. 1232-1244
    Details
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 30, No. 6 ( 2000-06), p. 1232-1244
    Type of Medium: Online Resource
    ISSN: 0022-3670 , 1520-0485
    URL: Article
    DOI: 10.1175/1520-0485(2000)030〈1232:MOOTMI〉2.0.CO;2
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2000
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  • 4
    Online Resource
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    Mutations in the gene encoding c-Abl-binding protein SH3BP2 cause cherubism
    Springer Science and Business Media LLC ; 2001
    In:  Nature Genetics Vol. 28, No. 2 ( 2001-6), p. 125-126
    Details
    In: Nature Genetics, Springer Science and Business Media LLC, Vol. 28, No. 2 ( 2001-6), p. 125-126
    Type of Medium: Online Resource
    ISSN: 1061-4036 , 1546-1718
    URL: Article
    DOI: 10.1038/88832
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2001
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  • 5
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    Psychotherapiemotivation älterer Patienten in der Rehabilitationsklinik - Eine empirische Studie
    Brill Deutschland GmbH ; 2000
    In:  Zeitschrift für Psychosomatische Medizin und Psychotherapie Vol. 46, No. 3 ( 2000-09-01), p. 259-272
    Details
    In: Zeitschrift für Psychosomatische Medizin und Psychotherapie, Brill Deutschland GmbH, Vol. 46, No. 3 ( 2000-09-01), p. 259-272
    Type of Medium: Online Resource
    ISSN: 1438-3608 , 2196-8349
    URL: Article
    DOI: 10.13109/zptm.2000.46.3.259
    Language: German
    Publisher: Brill Deutschland GmbH
    Publication Date: 2000
    SSG: 5,2
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  • 6
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    Turbulent Mixing in the Red Sea Outflow Plume from a High-Resolution Nonhydrostatic Model
    American Meteorological Society ; 2003
    In:  Journal of Physical Oceanography Vol. 33, No. 8 ( 2003-08-01), p. 1846-1869
    Details
    In: Journal of Physical Oceanography, American Meteorological Society, Vol. 33, No. 8 ( 2003-08-01), p. 1846-1869
    Abstract: Given the motivation that overflow processes, which supply source waters for most of the deep and intermediate water masses in the ocean, pose significant numerical and dynamical challenges for ocean general circulation models, an intercomparison study is conducted between field data collected in the Red Sea overflow and a high-resolution, nonhydrostatic process model. The investigation is focused on the part of the outflow that flows along a long narrow channel, referred to as the “northern channel,” that naturally restricts motion in the lateral direction such that the use of a two-dimensional model provides a reasonable approximation to the dynamics. This channel carries about two-thirds of the total Red Sea overflow transport, after the overflow splits into two branches in the western Gulf of Aden. The evolution of the overflow in the numerical simulations can be characterized in two phases: the first phase is highly time dependent, during which the density front associated with the overflow propagates along the channel. The second phase corresponds to that of a statistically steady state. The primary accomplishment of this study is that the model adequately captures the general characteristics of the system: (i) the gradual thickening of the overflow with downstream distance, (ii) the advection of high salinity and temperature signals at the bottom along the channel with little dilution, and (iii) ambient water masses sandwiched between the overflow and surface mixed layer. To quantify mixing of the overflow with the ambient water masses, an entrainment parameter is determined from the transport increase along the slope and is expressed explicitly as a function of mean slope angle. Bulk Richardson numbers are estimated both from data and model and are related to the entrainment parameter. The range of entrainment parameter and its functional dependence on bulk Richardson number in this study are found to be in reasonable agreement with those reported from various laboratory experiments and that based on measurements of the Mediterranean overflow. The results reveal a complex dynamical interaction between shear-induced mixing and internal waves and illustrate the high computational and modeling requirements for numerical simulation of overflows to capture (at least in part) turbulent transports explicitly.
    Type of Medium: Online Resource
    ISSN: 1520-0485 , 0022-3670
    URL: Article
    DOI: 10.1175/2401.1
    Language: English
    Publisher: American Meteorological Society
    Publication Date: 2003
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  • 7
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    The Impact of Disease Status at Transplant and Time to First Relapse on Outcome in Children and Adolescents with Hodgkin’s Lymphoma Undergoing Autologous Stem Cell Transplantation.
    American Society of Hematology ; 2004
    In:  Blood Vol. 104, No. 11 ( 2004-11-16), p. 1878-1878
    Details
    In: Blood, American Society of Hematology, Vol. 104, No. 11 ( 2004-11-16), p. 1878-1878
    Abstract: The prognosis of Hodgkin’s lymphoma (HL) in pediatric patients (pts) with current combined chemoradiotherapy regimens in general is excellent. Even those pts suffering from recurrent disease have a realistic chance for cure with salvage therapy regimens. 74 patients ( 〈 18 years at diagnosis; 69% male; 76% nodular sclerosis) mainly treated according to pediatric DAL or GPOH protocols received an autologous stem cell transplantation (ASCT) for recurrent or refractory disease between 1987 and 2003. 28 pts had progressive disease (PD, 〈 3 months following the end of therapy), 34 had an early relapse (3–12 months following cessation of therapy) and 12 had a late relapse ( 〉 12 months after therapy). Prior to ASCT, pts had a median of 3 (range, 2–4) lines of therapy and a median of 2 (range, 1–4) relapses/PD. At transplant, 63 pts had chemosensitive disease, defined as complete (CR) or partial remission (PR) and 11 had chemoresistant disease, defined as no change (NC) or primary refractory disease (PRD). Conditioning regimens were BEAM or variants in 47, CVB in 19 and others in 6 pts. Peripheral blood stem cells were used for most patients (76%). All pts engrafted. Additional post transplant radiotherapy was given to 24 pts. At a median follow up of 2.7 years (range, 0.1–12.8) 45 pts (61%) are alive and 29 are dead, which was attributed to the original disease in 21 pts. 42 of 63 pts (68%) with chemosensitive are alive compared to 2 of 11 (18%) with resistant disease (p=.002). Time to first relapse significantly attributed to survival after ASCT (12 of 28 pts with PD, 24 of 34 pts with early and 9 of 12 with late relapses are alive; p=.02). 30 pts (42%) relapsed and only 9 of these (30%) are alive compared to 36 pts (86%) with no relapse after ASCT. One pt received a second ASCT without success and 7 were allografted (2 alive). Probability of overall survival (OS), failure-free survival (FFS), relapse rate (RR) and treatment related mortality (TRM) at 5 years were 59%, 50%, 44%, and 12%, respectively. The following factors were adversely related to OS: early recurrence (p=.046), chemoresistance (p=.003), relapse after SCT (p 〈 .001). Probability of FFS in chemosensitive pts at 5 years was 59% while it was 0% in chemoresistant pts (p 〈 .001). FFS was superior for pts receiving BEAM compared to CVB (p=.057). Number of treatment lines were associated with TRM (p=.02). Factors predicting treatment failure in multifactorial analysis were chemoresistant disease at transplant and primary PD. In conclusion, ASCT can be performed safely with BEAM conditioning in children and adolescents. From these results, ASCT should be offered to pediatric pts with early recurrence of HL. For those pts with refractory disease, however, allogeneic transplantation with reduced intensity conditioning should be considered timely to provide an immunotherapeutic approach and to minimize treatment related mortality.
    Type of Medium: Online Resource
    ISSN: 0006-4971 , 1528-0020
    URL: Article
    DOI: 10.1182/blood.V104.11.1878.1878
    RVK:
    XA 33000
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Hematology
    Publication Date: 2004
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  • 8
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    Second‐moment closures and length scales for weakly stratified turbulent shear flows
    American Geophysical Union (AGU) ; 2000
    In:  Journal of Geophysical Research: Oceans Vol. 105, No. C3 ( 2000-03-15), p. 6453-6468
    Details
    In: Journal of Geophysical Research: Oceans, American Geophysical Union (AGU), Vol. 105, No. C3 ( 2000-03-15), p. 6453-6468
    Abstract: For the special hydrodynamic situation of unbounded homogeneous shear layers, turbulence closure models of Mellor‐Yamada type (MY) and k ‐ε type are put into a single canonical form. For this situation we show that conventional versions of MY and various k ‐ε versions lack a proper steady state, and are unable to simulate the most basic properties of stratified shear flows exemplified in, for example, the Rohr et al. [1988] experiments: exponential growth at sufficiently low gradient Richardson number ( R g ), exponential decay at sufficiently large R g , and a steady state in between. Proper choice of one special model parameter readily solves the problems. In the fairly general case of structural equilibrium (state of exponential evolution) in weakly to moderately stratified turbulence ( R g ≲ 0.25), the ratio between the Thorpe scale (or Ellison scale) and the Ozmidov scale varies like the gradient Richardson number ( R g ) to the power 3/4, and the ratio of the Thorpe scale to the buoyancy scale varies like R g 1/2 . Length scales predicted by our current model are consistent with laboratory measurements of Rohr et al. [1988], with large‐eddy numerical simulations of Schumann and Gerz [1995], and with microstructure measurements from the 1987 Tropic Heat Experiment in the equatorial Pacific by Peters et al. [1995].
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/1999JC900329
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2000
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    SSG: 16,13
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  • 9
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    Craniosynostosis in cherubism
    Wiley ; 2000
    In:  American Journal of Medical Genetics Vol. 95, No. 4 ( 2000-12-11), p. 325-331
    Details
    In: American Journal of Medical Genetics, Wiley, Vol. 95, No. 4 ( 2000-12-11), p. 325-331
    Type of Medium: Online Resource
    ISSN: 0148-7299 , 1096-8628
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/1096-8628(20001211)95:4〈〉1.0.CO;2-J
    DOI: 10.1002/(ISSN)1096-8628
    DOI: 10.1002/1096-8628(20001211)95:4〈325::AID-AJMG6〉3.0.CO;2-R
    RVK:
    WA 15000
    RVK:
    XA 18980
    Language: English
    Publisher: Wiley
    Publication Date: 2000
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    detail.hit.zdb_id: 1493479-6
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  • 10
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    Human Immunoglobulin M Memory B Cells Controlling Streptococcus pneumoniae Infections Are Generated in the Spleen
    Rockefeller University Press ; 2003
    In:  The Journal of Experimental Medicine Vol. 197, No. 7 ( 2003-04-07), p. 939-945
    Details
    In: The Journal of Experimental Medicine, Rockefeller University Press, Vol. 197, No. 7 ( 2003-04-07), p. 939-945
    Abstract: Splenectomized and asplenic patients have a high incidence of infections by encapsulated bacteria and do not respond to polysaccharide vaccines. To understand whether the absence of the spleen is associated with a defined B cell defect, we analyzed B cell subsets in the peripheral blood. We found that a population of B cells known as immunoglobulin (Ig)M memory is lacking in patients without spleen. The absence of IgM memory B cells correlates with an impaired immune response to encapsulated bacteria not only in splenectomized patients, but also in individuals with an intact spleen. We show that the physiological and transient predisposition to pneumococcal infections of young children (0–2 yr) is associated with the lack of circulating IgM memory B cells and of serum antipolysaccharide IgM. We also demonstrate that IgM memory B cells are undetectable in a fraction of patients with common variable immunodeficiency, who have recurrent and invasive infections by encapsulated bacteria. IgM memory B cells, therefore, require the spleen for their generation and/or survival and are responsible for the protection against encapsulated bacteria.
    Type of Medium: Online Resource
    ISSN: 1540-9538 , 0022-1007
    URL: Article
    DOI: 10.1084/jem.20022020
    RVK:
    XA 10000
    Language: English
    Publisher: Rockefeller University Press
    Publication Date: 2003
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