In:
International Journal of Cancer, Wiley, Vol. 144, No. 10 ( 2019-05-15), p. 2516-2528
Kurzfassung:
What's new? Contrary to other cancers, the mitochondrial content in colorectal cancer is frequently increased. Here, the authors point to the tumor inflammatory microenvironment as a critical inducer of mitochondrial biogenesis through increased expression of the mitochondrial single‐strand DNA binding protein (mtSSB). Because this upregulation is ultimately linked to increased cell proliferation, the authors propose that mtSSB‐mediated mitochondrial biogenesis may serve as a new therapeutic target in patients with colorectal cancer.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
218257-9
ZDB Id:
1474822-8
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