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  • 1
    Electronic Resource
    Electronic Resource
    Normal sister chromatid exchange in lymphocytes from patients with multiple epidermal cancer? (1987)
    Springer
    Archives of dermatological research 279 (1987), S. 180-183 
    Details
    ISSN: 1432-069X
    Keywords: Multiple epidermal cancer ; Sister chromatid exchange ; Lymphocyte UVC sensitivity ; Lymphocyte X-ray sensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Exposure to toxins in the environment and due to personal habits, e. g., tobacco smoking, may increase the rate of spontaneous sister chromatid exchange (SCE). The SCE in lymphocytes from a group of 31 patients with multiple epidermal cancer, who in the past had been exposed to various skin carcinogens, as a whole exceeded that of a control group — matched by sex, age, and smoking habits — but the difference was not statistically significant (p=0.08). The individual SCE in these patients was also statistically independent of the nature of the carcinogenic exposure. We were unable to detect correlations between the SCE and UVC-radiation induced DNA synthesis, UVC-radiation tolerance, or rate of X-ray damage repair. This suggests that the molecular mechanisms involved in SCE induction and in repair of radiation damage are basically independent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00413254
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  • 2
    Electronic Resource
    Electronic Resource
    Acute effect of 8-methoxypsoralen and ultraviolet light on sister chromatid exchange (1978)
    Springer
    Archives of dermatological research 263 (1978), S. 37-46 
    Details
    ISSN: 1432-069X
    Keywords: Sister chromatid exchange ; 8-MOP ; ultraviolet light ; Schwester-chromatiden-Austausch ; 8-MOP, langwelliges UV-Licht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die unmittelbare Wirkung von 8-Methoxypsoralen (8-MOP) sowie von 8-MOP+langwelligem UV-Licht (UVA) auf Schwesterchromatiden-Austausch (SCE) wurde in einem in vitro-Experiment untersucht. Der SCE nach 8-MOP allein war signifikant erhöht, aber die Wirkung war wesentlich größer (50%) nach der Behandlung mit 8-MOP+UVA. Dazu wurden nach der Behandlung mit 8-MOP-Mitosen mit «gestreifter» Färbung der Chromosomen beobachtet. Die Veränderungen sind dosisabhängig und bilden möglicherweise die Ursache für die nach PUVA-Behandlung verminderte Zellteilung in Psoriasisflecken.
    Notes: Summary The acute effect of 8-methoxypsoralen (8-MOP) and 8-MOP+long wave ultraviolet light (UVA) on sister chromatid exchange (SCE) has been examined in an in vitro experiment. The SCE count was significantly increased by 8-MOP without light, but the effect was substantially greater (50%) by 8-MOP+UVA. In addition, mitoses with banded staining of the chromosomes were seen after 8-MOP and UVA. These changes were dose dependent, and they might be responsible for the reduced cell turnover in psoriasis plaque after PUVA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446852
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    Paper (German National Licenses)
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