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  • Methadone treatment  (2)
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  • 1
    Electronic Resource
    Electronic Resource
    Variability in simian motor and social behavior with alternating-day acetylmethadol (1985)
    Springer
    Psychopharmacology 85 (1985), S. 353-360 
    Details
    ISSN: 1432-2072
    Keywords: Drug Abuse ; Methadone treatment ; Spontaneous motility ; Social behavior ; Sexual behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monkeys receiving acetylmethadol thrice weekly were more active on dosing days, and less active on between-dose days, than while drug-free. Aggressive social behaviours increased significantly on drug-dosing days, while quiescent resting behaviors were much more common on between-dose days. Tolerance to these effects was modest, and the effects were not blocked by naltrexone. These subtle but potentially disruptive behavioral effects appear to parallel many of the actions of acetylmethadol in man.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428201
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Acetylmethadol versus methadone: Human mood and motility (1985)
    Springer
    Psychopharmacology 86 (1985), S. 458-463 
    Details
    ISSN: 1432-2072
    Keywords: Drug Abuse ; Methadone treatment ; Spontaneous motility ; Social behavior ; Sexual behavior
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Outpatients receiving daily methadone-maintenance treatment were crossed over to alternating-day doses of l-alpha-acetylmethadol, receiving placebo on between-dose days. Spontaneous motility was dramatically higher on acetylmethadol dose days than on placebo days; activity on methadone days was intermediate between these extremes. Patients reported less vigor, more fatigue, and fewer ejaculations on placebo days than on acetylmethadol days, and patients' mood while on this drug was slightly euphoric in comparison to methadone. These effects are subtle, but such drug-induced variations in day-to-day behavior might adversely affect social interactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427908
    Location Call Number Limitation Availability
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    Paper (German National Licenses)
    Fulltext
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